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MTHFD2 encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. Additionally we are shipping Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase Antibodies (48) and Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase Kits (5) and many more products for this protein.
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Data suggest that Ad4BP (show NR5A1 Proteins) plays role in regulation of intracellular NADPH (show FDXR Proteins) concentration via transcription of Me1 (show ME1 Proteins) and Mthfd2 genes in adrenocortical cells. (Ad4BP (show NR5A1 Proteins) = nuclear receptor subfamily 5 group A member 1 (show NR5A1 Proteins); Me1 (show ME1 Proteins) = malic enzyme 1 (show ME1 Proteins); Mthfd2 = bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase)
A mutation in methylenetetrahydrofolate reductase (MTHFR (show MTHFR Proteins)) gene, may contribute to the risk of both arterial and deep-vein thrombosis in patients with nephrotic syndrome.
metabolic alterations in MCF7 cells observed as a consequence of MTHFD2 suppression
crystal structure of MTHFD2 in complex with a substrate-based inhibitor and the enzyme cofactors NAD(+) and inorganic phosphate.
Mechanistically, MYC (show MYC Proteins) regulates the expression of MTHFD2, and MTHFD2 knockdown suppresses the TCA cycle.
siRNA-mediated silencing of MTHFD2 inhibited migration, invasion and epithelial-mesenchymal transition progression in hepatocellular carcinoma (HCC (show FAM126A Proteins)) cell lines, but no obvious effects on cell proliferation, apoptosis or cell cycle distribution were detected. MTHFD2 is overexpressed in HCC (show FAM126A Proteins), and is associated with poor prognosis and cellular features connected to metastatic disease.
These findings suggest a previously unknown role for MTHFD2 in cancer cell proliferation, adding to its known function in mitochondrial folate metabolism.
The highest scoring pathway is mitochondrial one-carbon metabolism and is centred on MTHFD2.
Data indicate that methylenetetrahydrofolate dehydrogenase (NADP + -dependent) 2 (MTHFD2)was differentially expressed in breast cancer tissue, suggesting as a prognostic factor and a potential therapeutic target for future breast cancer treatments.
Data indicate that the reduced vimentin (show VIM Proteins) expression in response to EPHB4 (show EPHB4 Proteins), WIPF2 and MTHFD2 silencing was observed at mRNA and protein levels.
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7.
bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
, methylene tetrahydrofolate dehydrogenase 2
, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
, methylenetetrahydrofolate dehydrogenase 2
, NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase
, methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
, methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase