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METTL3 encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. Additionally we are shipping METTL3 Kits (4) and METTL3 Proteins (4) and many more products for this protein.
Showing 10 out of 29 products:
Bat Polyclonal METTL3 Primary Antibody for WB - ABIN610637
Ginkel, Wordeman: Expression and partial characterization of kinesin-related proteins in differentiating and adult skeletal muscle. in Molecular biology of the cell 2000
Show all 2 Pubmed References
Human Polyclonal METTL3 Primary Antibody for IF, WB - ABIN1327559
Ping, Sun, Wang, Xiao, Yang, Wang, Adhikari, Shi, Lv, Chen, Zhao, Li, Yang, Dahal, Lou, Liu, Huang, Yuan, Zhu, Cheng, Zhao, Wang, Rendtlew Danielsen, Liu, Yang: Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. in Cell research 2014
The role of METTL3 in pancreatic cancer cells drug resistance and radiation resistance.METTL3 was associated with mitogen-activated protein kinase cascades, ubiquitin-dependent process and RNA splicing and regulation of cellular process.
METTL3 is soluble and inactive while the catalytic center of METTL14 (show METTL14 Antibodies) is degenerated and thus also inactive. In addition, the C-terminal RGG repeats of METTL14 (show METTL14 Antibodies) are required for METTL3/14 activity by contributing to RNA substrate binding.
data define METTL3 as a regulator of a chromatin-based pathway that is necessary for maintenance of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia
methylation at m6A (show GPM6A Antibodies) by METTL3/METTL14 (show METTL14 Antibodies) facilitates the methylation of m5C by NSUN2 (show NSUN2 Antibodies), and vice versa. NSUN2 (show NSUN2 Antibodies)-mediated m5C and METTL3/METTL14 (show METTL14 Antibodies)-mediated m6A (show GPM6A Antibodies) methylation synergistically enhance p21 (show CDKN1A Antibodies) expression at the translational level
loss of METTL3 leads to increased levels of phosphorylated AKT (show AKT1 Antibodies), which contributes to the differentiation-promoting effects of METTL3 depletion. Overall, these results provide a rationale for the therapeutic targeting of METTL3 in myeloid leukemia (show BCL11A Antibodies)
The structure reveals the heterodimeric architecture of the complex and donor substrate binding by METTL3. Structure-guided mutagenesis indicates that METTL3 is the catalytic subunit of the complex, whereas METTL14 (show METTL14 Antibodies) has a degenerate active site and plays non-catalytic roles in maintaining complex integrity and substrate RNA binding.
For the methylation of adenosine in RNA, Mettl3 is the catalytically active subunit, while Mettl14 (show METTL14 Antibodies) plays a structural role critical for substrate recognition.
METTL3 enhances mRNA translation through an interaction with the translation initiation machinery in lung adenocarcinoma cells.
miR (show MLXIP Antibodies)-33a can attenuatenon-small-cell lung carcinoma cells proliferation via targeting to the 3'-untranslated region of METTL3 mRNA.
Structure of the METTL3-METTL14 (show METTL14 Antibodies) complex
The data showed that Mettl3 is required for MyoD (show MYOD1 Antibodies) mRNA expression in proliferative myoblasts.
Mettl3 was essential for male fertility and spermatogenesis.
Combined deletion of Mettl3 and Mettl14 (show METTL14 Antibodies) in advanced germ cells with Stra8 (show STRA8 Antibodies)-GFPCre disrupts spermiogenesis, whereas mice with single deletion of either Mettl3 or Mettl14 (show METTL14 Antibodies) in advanced germ cells show normal spermatogenesis.
this study identifies Mettl3, an N(6)-methyladenosine (m(6)A) transferase, as a regulator for terminating murine naive pluripotency.
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
N6-adenosine-methyltransferase 70 kDa subunit
, adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
, mRNA m(6)A methyltransferase
, methyltransferase-like protein 3
, m6a methyltransferase
, methyltransferase-like 3