anti-Methyltransferase Like 3 (METTL3) Antibodies

METTL3 encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. Additionally we are shipping METTL3 Kits (4) and METTL3 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
METTL3 56339 Q86U44
METTL3 56335 Q8C3P7
METTL3 361035  
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Top anti-METTL3 Antibodies at antibodies-online.com

Showing 10 out of 31 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-METTL3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human brain 100 μL Log in to see 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-METTL3 Antibody   Titration: 1.0 ug/ml   Positive Control: HepG2 Whole Cell METTL3 is supported by BioGPS gene expression data to be expressed in HepG2 WB Suggested Anti-METTL3 AntibodyTitration: 1.0 µg/mL  Positive Control: HepG2 Whole Cell  METTL3 is supported by BioGPS gene expression data to be expressed in HepG2 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-METTL3 Antibody Titration:  5.0ug/ml  ELISA Titer:  1:312500  Positive Control:  Raji cell lysate METTL3 is strongly supported by BioGPS gene expression data to be expressed in Human Raji cells Host:  Rabbit  Target Name:  METTL3  Sample Tissue:  Human HepG2  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Rabbit Un-conjugated IHC, WB Human Intestine WB Suggested Anti-METTL3 Antibody Titration:  5.0ug/ml  ELISA Titer:  1:312500  Positive Control:  Human Thymus 100 μL Log in to see 2 to 3 Days
$249.00
Details
Human Rabbit Un-conjugated IHC, IP, WB Western blot analysis of extracts of various cell lines, using METTL3 antibody. Immunohistochemistry of paraffin-embedded human lung cancer using METTL3 antibody. 100 μL Log in to see 13 to 14 Days
$393.25
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using METTL3 antibody. Immunohistochemistry of paraffin-embedded human lung cancer using METTL3 antibody at dilution of 1:100 (40x lens). 100 μL Log in to see 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: Molt-4 , 7.5% SDS PAGE antibody diluted at 1:10000 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see Available
$363.46
Details
Bat Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$493.17
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details

Top referenced anti-METTL3 Antibodies

  1. Human Polyclonal METTL3 Primary Antibody for IHC, IP - ABIN6683369 : Xiang, Laurent, Hsu, Nachtergaele, Lu, Sheng, Xu, Chen, Ouyang, Wang, Ling, Hsu, Zou, Jambhekar, He, Shi: RNA m6A methylation regulates the ultraviolet-induced DNA damage response. in Nature 2017 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal METTL3 Primary Antibody for IHC, IP - ABIN6143771 : Xiang, Yang, Liu, Wu, Chen, Yang: N6-Methyladenosines Modulate A-to-I RNA Editing. in Molecular cell 2018 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal METTL3 Primary Antibody for IF, WB - ABIN1327559 : Ping, Sun, Wang, Xiao, Yang, Wang, Adhikari, Shi, Lv, Chen, Zhao, Li, Yang, Dahal, Lou, Liu, Huang, Yuan, Zhu, Cheng, Zhao, Wang, Rendtlew Danielsen, Liu, Yang: Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. in Cell research 2014 (PubMed)

More Antibodies against METTL3 Interaction Partners

Human Methyltransferase Like 3 (METTL3) interaction partners

  1. METTL3-eIF3h interaction is required for enhanced translation, formation of densely packed polyribosomes and oncogenic transformation; findings uncover a mechanism of translation control that is based on mRNA looping and identify METTL3-eIF3h as a potential therapeutic target for patients with cancer

  2. METTL3 acts as an oncogene in myeloid leukemia MOLM13 cells by upregulating MYC expression.

  3. Findings suggest that METTL3 plays very important oncogenic roles in ovarian carcinoma development and/or aggressiveness by stimulating AXL translation and EMT.

  4. Data show that hepatitis B X-interacting protein (HBXIP) modulated Methyltransferase-like 3 (METTL3) by inhibiting miRNA let-7g, which down-regulated the expression of METTL3 by targeting its 3'UTR.

  5. Study reports the importance of m6A modification in glioma stem-like cells and uncovers METTL3 as a potential molecular target in glioblastoma therapy.

  6. The role of METTL3 in pancreatic cancer cells drug resistance and radiation resistance.METTL3 was associated with mitogen-activated protein kinase cascades, ubiquitin-dependent process and RNA splicing and regulation of cellular process.

  7. METTL3 is soluble and inactive while the catalytic center of METTL14 is degenerated and thus also inactive. In addition, the C-terminal RGG repeats of METTL14 are required for METTL3/14 activity by contributing to RNA substrate binding.

  8. data define METTL3 as a regulator of a chromatin-based pathway that is necessary for maintenance of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia

  9. methylation at m6A by METTL3/METTL14 facilitates the methylation of m5C by NSUN2, and vice versa. NSUN2-mediated m5C and METTL3/METTL14-mediated m6A methylation synergistically enhance p21 expression at the translational level

  10. loss of METTL3 leads to increased levels of phosphorylated AKT, which contributes to the differentiation-promoting effects of METTL3 depletion. Overall, these results provide a rationale for the therapeutic targeting of METTL3 in myeloid leukemia

  11. The structure reveals the heterodimeric architecture of the complex and donor substrate binding by METTL3. Structure-guided mutagenesis indicates that METTL3 is the catalytic subunit of the complex, whereas METTL14 has a degenerate active site and plays non-catalytic roles in maintaining complex integrity and substrate RNA binding.

  12. For the methylation of adenosine in RNA, Mettl3 is the catalytically active subunit, while Mettl14 plays a structural role critical for substrate recognition.

  13. METTL3 enhances mRNA translation through an interaction with the translation initiation machinery in lung adenocarcinoma cells.

  14. miR-33a can attenuatenon-small-cell lung carcinoma cells proliferation via targeting to the 3'-untranslated region of METTL3 mRNA.

  15. Structure of the METTL3-METTL14 complex

  16. genetic inactivation impaired embryonic stem cells differentiation

  17. Study identifies m(6)A methylation sites on many clock gene transcripts and shows that specific inhibition of m(6)A methylation by silencing of the m(6)A methylase Mettl3 is sufficient to elicit circadian period elongation and RNA processing delay.

Mouse (Murine) Methyltransferase Like 3 (METTL3) interaction partners

  1. Mettl3-mediated mRNA m(6)A methylation promotes dendritic cell activation.

  2. analysis established that METTL3-mediated N6-methyladenosine participates in cerebellar development by controlling mRNA stability of genes related to cerebellar development and apoptosis and by regulating alternative splicing of pre-mRNAs of synapse-associated genes.

  3. Conditional knockout of Mettl3 in bone marrow mesenchymal stem cells (MSCs) induces pathological features of osteoporosis in mice. Mettl3 loss-of-function results in impaired bone formation, incompetent osteogenic differentiation potential and increased marrow adiposity. Moreover, Mettl3 overexpression in MSCs protects the mice from estrogen deficiency-induced osteoporosis.

  4. The data showed that Mettl3 is required for MyoD mRNA expression in proliferative myoblasts.

  5. Mettl3 was essential for male fertility and spermatogenesis.

  6. Combined deletion of Mettl3 and Mettl14 in advanced germ cells with Stra8-GFPCre disrupts spermiogenesis, whereas mice with single deletion of either Mettl3 or Mettl14 in advanced germ cells show normal spermatogenesis.

  7. data define METTL3 as a regulator of a chromatin-based pathway that is necessary for maintenance of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia

  8. genetic inactivation impaired embryonic stem cells differentiation

  9. this study identifies Mettl3, an N(6)-methyladenosine (m(6)A) transferase, as a regulator for terminating murine naive pluripotency.

METTL3 Antigen Profile

Protein Summary

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.

Gene names and symbols associated with METTL3

  • methyltransferase like 3 (mettl3) antibody
  • methyltransferase like 3 L homeolog (mettl3.L) antibody
  • methyltransferase like 3 (METTL3) antibody
  • methyltransferase like 3 (Mettl3) antibody
  • methyltransferase-like 3 (Mettl3) antibody
  • 2310024F18Rik antibody
  • fj82g07 antibody
  • IME4 antibody
  • M6A antibody
  • MT-A70 antibody
  • Spo8 antibody
  • wu:fj82g07 antibody
  • zgc:77093 antibody

Protein level used designations for METTL3

N6-adenosine-methyltransferase 70 kDa subunit , adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase , mRNA m(6)A methyltransferase , methyltransferase-like protein 3 , MT-A70 , m6a methyltransferase , methyltransferase-like 3

GENE ID SPECIES
100004398 Danio rerio
414662 Xenopus laevis
56339 Homo sapiens
475404 Canis lupus familiaris
540339 Bos taurus
56335 Mus musculus
361035 Rattus norvegicus
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