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METTL3 encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. Additionally we are shipping METTL3 Antibodies (24) and METTL3 Kits (2) and many more products for this protein.
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methylation at m6A (show GPM6A Proteins) by METTL3/METTL14 (show METTL14 Proteins) facilitates the methylation of m5C by NSUN2 (show NSUN2 Proteins), and vice versa. NSUN2 (show NSUN2 Proteins)-mediated m5C and METTL3/METTL14 (show METTL14 Proteins)-mediated m6A (show GPM6A Proteins) methylation synergistically enhance p21 (show CDKN1A Proteins) expression at the translational level
loss of METTL3 leads to increased levels of phosphorylated AKT (show AKT1 Proteins), which contributes to the differentiation-promoting effects of METTL3 depletion. Overall, these results provide a rationale for the therapeutic targeting of METTL3 in myeloid leukemia (show BCL11A Proteins)
The structure reveals the heterodimeric architecture of the complex and donor substrate binding by METTL3. Structure-guided mutagenesis indicates that METTL3 is the catalytic subunit of the complex, whereas METTL14 (show METTL14 Proteins) has a degenerate active site and plays non-catalytic roles in maintaining complex integrity and substrate RNA binding.
For the methylation of adenosine in RNA, Mettl3 is the catalytically active subunit, while Mettl14 (show METTL14 Proteins) plays a structural role critical for substrate recognition.
METTL3 enhances mRNA translation through an interaction with the translation initiation machinery in lung adenocarcinoma cells.
miR (show MLXIP Proteins)-33a can attenuatenon-small-cell lung carcinoma cells proliferation via targeting to the 3'-untranslated region of METTL3 mRNA.
Structure of the METTL3-METTL14 (show METTL14 Proteins) complex
Study identifies m(6)A methylation sites on many clock gene transcripts and shows that specific inhibition of m(6)A methylation by silencing of the m(6)A methylase Mettl3 is sufficient to elicit circadian period elongation and RNA processing delay.
this study identifies Mettl3, an N(6)-methyladenosine (m(6)A) transferase, as a regulator for terminating murine naive pluripotency.
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
N6-adenosine-methyltransferase 70 kDa subunit
, adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
, mRNA m(6)A methyltransferase
, methyltransferase-like protein 3
, m6a methyltransferase
, methyltransferase-like 3