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Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. Additionally we are shipping MCRS1 Antibodies (46) and MCRS1 Proteins (3) and many more products for this protein.
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Results suggest that dMCRS2 is required for loading of RNAP II complexes on the cyclin gene promoters.
Study shows that MCRS1 binds to cytoplasmic dynein and contributes to the establishment of centriolar satellites and ciliogenesis.
MSP58 downregulation suppressed the proliferation and invasion of renal cell carcinoma cells.
MCRS1 is phosphorylated by the Aurora-A kinase in mitosis on Ser35/36.
RINT-1 interacts with MSP58 and UBF within nucleoli and plays a role in ribosomal gene transcription.
The immunoreactivity score (IRS) of MSP58 increased with tumor grade with grade IV gliomas exhibiting the highest expression and showed a highly significant positive correlation with the Ki-67 index (r = 0.65, P < 0.001).
Suggest that MSP58 plays an important role in tumorigenesis and progression and may help predict the prognosis of gastric cancer patients.
MCRS1 overexpression induced non-small cell lung cancer proliferation through the miR-155-Rb1 pathway and DNA copy-number amplification is one of the mechanisms underlying MCRS1 overexpression in non-small cell lung cancer.
MSP58 subnuclear localization is regulated by two nuclear import signals, and proper subcellular localization of MSP58 is critical for its role in transcriptional regulation. A molecular mechanism controls nuclear and nucleolar localization of MSP58.
BAP1 loss and MCRS1 down-regulation in renal cell carcinoma are associated with adverse clinicopathological features.
MiR-129* down-regulation induced MCRS1 overexpression.
High expression of MSP58 was also an independent unfavorable prognostic factor.
MSP58 could suppress the transcription of hTERT promoter.
MSP58 expression in hepatocellular carcinoma is closely related to the prognosis.
Our results demonstrated MSP58 might serve as a novel prognostic marker for colorectal cancer
MSP58 contributes to the tumorigenesis of neuroblastoma by promoting cell proliferation.
RACGAP1 and MCRS1 overexpression in nonsmall-cell lung cancer.RACGAP1 and MCRS1 may be cancer-related genes in NSCLC.
MSP58 depletion induced cell cycle arrest.
Interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression.
Our findings highlight new aspects of MSP58 in modulating cellular senescence and suggest that MSP58 has both oncogenic and tumor-suppressive properties.
MCRS2 plays a negative role in stress-induced ASK1 activation.
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity.
, lethal (3) rG166
, reduction in Cnn dots 5
, microspherule protein 1
, microspherule protein 1-like
, 58 kDa microspherule protein
, nucleolar protein
, INO80 complex subunit J
, INO80 complex subunit Q
, cell cycle-regulated factor (78 kDa)
, cell cycle-regulated factor p78