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MAP6 encodes a microtubule-associated protein. Additionally we are shipping MAP6 Antibodies (11) and many more products for this protein.
Showing 5 out of 6 products:
the concentration of STOP/MAP6 protein was significantly reduced in the plasma of autistic subjects than that in healthy controls.
These data show that TMEM106B/MAP6 interaction is crucial for controlling dendritic trafficking of lysosomes, presumably by acting as a molecular brake for retrograde transport.
Structural basis for the association of MAP6 protein with microtubules and its regulation by calmodulin.
MAP6 might serve as a temperature sensor adapting its conformation according to the temperature to maintain the cellular microtubule network in organisms exposed to temperature decrease.
show that MAP6 proteins interact directly with both Tctex1 (show DYNLT1 Proteins) and the C-terminus of Cav2.2 (show CACNA1B Proteins)/N-type calcium channels.
MAP6 is present at the Golgi complex and in secretory vesicles in unpolarized cells and re-distributed to newly forming axons, where it binds and stabilizes axonal microtubules. A palmitoylation cycle controls MAP6 membrane-microtubule shuttling and is required for its polarized distribution in axons.
Mice deficient in stable tubule only polypeptide (STOP) show sleep/wake patterns that resemble those seen in patients with schizophrenia.
MAP6 deletion disrupts brain connectivity and is associated with a lack of post-commissural fornix fibres. MAP6 contributes to fornix development by regulating axonal elongation induced by Semaphorin 3E (show SEMA3E Proteins).
STOP/Map6 knockout mice are a valid model for cognitive deficits in schizophrenia.
STOP null mice displayed elevated levels of endogenous morphine, as well as an increase of morphine receptor affinity and density in brain. This was correlated with hypernociception and impaired pharmacological sensitivity to mu opioid receptor (show OPRM1 Proteins) ligands
interacts with neuronal tubulin (show TUBB Proteins) independently of polyglutamylation
there is a single neuronal specific promoter for transcription of E- and N-STOP mRNAs. F-STOP mRNA transcription is regulated by a distinct promoter that lies within coding sequences expressed in neuronal E- and N-STOP isoforms.
STOP phosphorylation by CaMKII may promote STOP translocation from microtubules to synaptic compartments where it may interact with actin, which could be important for STOP function in synaptic plasticity
This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene.
, stable tubule-only polypeptide
, 145-kDa STOP
, microtubule-associated protein 6 homolog
, MAP-6 homolog
, putative microtubule associated protein
, stable tubule-only polypeptide homolog
, LOW QUALITY PROTEIN: microtubule-associated protein 6
, microtubule-associated protein 6