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MTUS1 encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization.
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MTUS1 is not only involved in the formation and progression of human cancers but also involved in the complex pathological conditions such as cardiac hypertrophy, atherosclerosis, and SLE-like lymphoproliferative diseases. Several molecular mechanisms such as proliferation, differentiation, DNA repair, inflammation, vascular remodeling and senescence appear to be tightly regulated by the MTUS1-encoded proteins.
findings have provided the first clues regarding the roles of miR (show MLXIP Proteins)-19a/b, which appear to function as oncomirs in lung cancer by downregulating MTUS1.
angiotensin II type 2 receptor-interacting protein 3a presents potential in suppressing the proliferation and aggressiveness of ovarian carcinoma cells through the high mobility group AT-hook 2-mediated extracellular signal-regulated kinase/epithelial-to-mesenchymal transition signal pathway.
Our findings showed that MTUS1 regulates the p38 MAPK (show MAPK14 Proteins)-mediated cytokine production in ECs. MTUS1 gene probably plays a protective role against pro-inflammatory response of ECs.
Deregulated microRNA (miRNA) expression has been shown to be involved in the pathogenesis of several types of cancers including colorectal cancer (CRC (show CALR Proteins)). MTUS1 targeting miRNAs may play key roles in the development of CRC (show CALR Proteins) by downregulating tumor suppressor MTUS1.
Study reports differential expression of MTUS1 and its regulatory miRNAs in breast cancer and fibroadenoma tissues; among MTUS1 targeting miRNAs, miR (show MLXIP Proteins)-183-5p was overexpressed in breast cancer and down-regulated in fibroadenoma tissues; expression levels of MTUS1 and miR (show MLXIP Proteins)-183-5p correlated with clinical parameters. In particular, MTUS1 was found to be diminished and miR (show MLXIP Proteins)-183-5p was elevated with advancing stage.
We propose a novel mechanism by which ATIP3-EB1 (show MAPRE2 Proteins) interaction indirectly reduces the kinetics of EB1 (show MAPRE2 Proteins) exchange on its recognition site, thereby accounting for negative regulation of microtubule dynamic instability
Our studies confirm that MTUS1 plays an important role in the progression of salivary adenoid cystic carcinoma , and may serve as a biomarker or therapeutic target for patients with salivary adenoid cystic carcinoma
Data identifies MTUS1 as a tumour suppressor gene in cultured bladder cancer cells and in advanced bladder tumours.
The present data suggested MTUS1 as a potential tumor suppressor in gastric cancer and might lead to a better understanding of gastric carcinogenesis.
ICIS and Aurora B (show AURKB Proteins) coregulate the microtubule depolymerase Kif2a (show KIF2A Proteins).
important role in AT2 receptor (show AGTR2 Proteins)-mediated PPARgamma (show PPARG Proteins) activation
ATIPs seem to be mainly involved in the developmental regulation of the cardiovascular system and may act in different AT2-dependent and -independent manners.
ATIP1 could exert anti-inflammatory effects in adipose tissue via macrophage polarization associated with improvement of insulin (show INS Proteins) resistance.
Reports the first generation of a MTUS1 KO mouse, developing spontaneous heart hypertrophy and increased cell proliferation, confirming once more the anti-proliferative effect of MTUS1, and a SLE-like lymphoproliferative disease.
ATIP3 is a novel microtubule-associated protein (show SPAG5 Proteins) related to MTUS1, with a role in invasiveness and progression of breast neoplasms
Results identify ATIP1 (angiotensin II AT2 receptor-interacting protein) as a novel early component of growth inhibitory signaling cascade.
ATIP1 plays an important role in cuff-induced vascular remodeling in mice
This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.
mitochondrial tumor suppressor 1
, AT2 receptor-binding protein
, AT2 receptor-interacting protein
, AT2R binding protein
, angiotensin-II type 2 receptor-interacting protein
, erythroid differentiation-related
, microtubule-associated tumor suppressor 1
, mitochondrial tumor suppressor gene 1
, transcription factor MTSG1
, microtubule-associated tumor suppressor 1 homolog
, mitochondrial tumor suppressor 1 homolog
, growth factor inhibitor
, F-box protein 27
, inner centromere Kin-I stimulator
, inner centromere KinI stimulator
, AT2 receptor-interacting protein 1
, angiotensin II AT2 receptor-interacting protein 1
, coiled-coiled tumor suppressor gene 1 protein
, coiled-coiled tumor supressor gene 1