anti-Microtubule-Actin Crosslinking Factor 1 (MACF1) Antibodies

The protein encoded by MACF1 belongs to the plakin family of cytoskeletal linker proteins. Additionally we are shipping MACF1 Kits (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MACF1 23499 Q9UPN3
MACF1 11426  
MACF1 362587  
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Top anti-MACF1 Antibodies at

Showing 10 out of 13 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged MACF1 is approximately 1ng/ml as a capture antibody. 100 μg 11 to 12 Days
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.45 KDa) . 50 μL 11 to 12 Days
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged MACF1 is 0.03 ng/ml as a capture antibody. Western Blot detection against Immunogen (36.08 KDa) . 100 μg 11 to 12 Days
Mouse Rabbit FITC ICC, IF, ELISA, WB   100 μg 1 to 2 Days
Human Rabbit Un-conjugated ELISA, IHC   50 μL 11 to 16 Days
Mouse Rabbit Un-conjugated ICC, IF, ELISA, WB   100 μg 1 to 2 Days
Human Rabbit Un-conjugated ELISA, IF, IHC   100 μg 13 to 16 Days
Human Rabbit Un-conjugated IHC, ELISA   50 μL 9 to 11 Days
Human Rabbit Un-conjugated ELISA, IF/ICC, IHC   100 μg 11 to 18 Days
Mouse Rabbit Biotin ELISA, ICC, IF, WB   100 μg 1 to 2 Days

Top referenced anti-MACF1 Antibodies

  1. Human Polyclonal MACF1 Primary Antibody for ELISA, WB - ABIN565101 : Khositseth, Pisitkun, Slentz, Wang, Hoffert, Knepper, Yu: Quantitative protein and mRNA profiling shows selective post-transcriptional control of protein expression by vasopressin in kidney cells. in Molecular & cellular proteomics : MCP 2011 (PubMed)

  2. Human Monoclonal MACF1 Primary Antibody for ELISA - ABIN565102 : Hotta, Kawakatsu, Nakatani, Sato, Matsui, Sukezane, Akagi, Hamaji, Grigoriev, Akhmanova, Takai, Mimori-Kiyosue: Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta. in The Journal of cell biology 2010 (PubMed)

More Antibodies against MACF1 Interaction Partners

Zebrafish Microtubule-Actin Crosslinking Factor 1 (MACF1) interaction partners

  1. We propose that Macf1a does not function via its canonical mechanism of linking two cytoskeletal systems together in dissociating the Bb. Instead our results suggest that Macf1a functions by linking one cytoskeletal system, cortical actin, to another structure, the Bb, where Macf1a is localized.

  2. Macf1 regulates the balbiani body and the polarity of oocyte.

Human Microtubule-Actin Crosslinking Factor 1 (MACF1) interaction partners

  1. Three de novo variants in MACF1 have been observed in large schizophrenia cohorts.

  2. In this study, uncontrolled Diabetes mellitus (DM) had a remote impact on different components of the platelet transcriptome. Increased expression of MACF1, together with supporting predicted mRNA-miRNA interactions as well as reduced expression of RNYs in platelets, may reflect subclinical platelet activation in uncontrolled DM.

  3. MACF1 overexpression triggered a drastic increase in osteogenic gene expression, alkaline phosphatase activity, and matrix mineralization in vitro. Mouse calvarial thickness, mineral apposition rate, and osteogenic marker protein expression were significantly enhanced by local transfection. In addition, MACF1 overexpression promoted beta-catenin expression and signaling.

  4. Loss of ACF7 leads to aberrant microtubule organization, tight junction stabilization and impaired wound closure in vitro. ACF7 level is also correlated with development and progression of ulcerative colitis (UC) in patients.

  5. Study summarized the physiological role of MACF1 as well as its pathological one in various cancers. MACF1 comprises different isoforms, and is broadly expressed in brain, spinal cord, lung, kidney, heart, bone and skeletal muscles tissues. It plays a crucial role in cell proliferation, migration and cell signaling, and is also closely associated with many cancer.

  6. in mammalian intestinal epithelial cells, the spectraplakin ACF7 (also known as MACF1) specifically binds to CAMSAP3 and is required for the apical localization of CAMSAP3-decorated microtubule minus ends.

  7. MACF1b may contribute to the genetic etiology and mechanistic causation of Parkinson's disease.

  8. ACF7, a member of the spectraplakin family of cytoskeletal crosslinking proteins, interacts with Nezha (also called CAMSAP3) at the minus ends of noncentrosomal microtubules and anchors them to actin filaments.

  9. the present study represents the first investigation on the functional role of MACF1 in tumor cell biology, as well as demonstrates its potential as a unique biomarker that can be targeted synergistically with TMZ as part of a combinatorial therapeutic approach for the treatment of genetically multifarious glioblastomas

  10. Duplication in the microtubule-actin cross-linking factor 1 gene causes neuromuscular diseases.

  11. uncovered a role for ELMO in the recruitment of ACF7 to the membrane to promote microtubule capture and stability

  12. ACF7 targeting to the plasma membrane is both required and sufficient for microtubule capture downstream of ErbB2.

  13. p230, through its interaction with MACF1, provides the molecular link for transport of GPI-anchored proteins along the microtubule and actin cytoskeleton from the TGN to the cell periphery.

  14. In two lung cell lines, MACF1b was chiefly localized to the Golgi complex. The domain of MACF1b that targets it to the Golgi was found at the N-terminal part of the region that contains the plakin repeats.

  15. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia.

Mouse (Murine) Microtubule-Actin Crosslinking Factor 1 (MACF1) interaction partners

  1. mechanical unloading decreases MACF1 expression, and MACF1 up-regulates osteoblast proliferation through enhancing beta-catenin signaling. This study has thus provided a mechanism for mechanical unloading-induced inhibited osteoblast proliferation.

  2. High fat diet and ACF7 knock-out have synergistic damaging effects on intestinal homeostasis.

  3. ablation of ACF7 inhibits intestinal wound healing and greatly increases susceptibility to experimental colitis

  4. FAK/Src-mediated phosphorylation of ACF7 is essential for F-actin binding of ACF7 and coordinated cytoskeletal dynamics at focal adhesions.

  5. These findings demonstrate a novel role for MACF1 in neurite differentiation that is critical to the creation of neuronal connectivity in the developing brain.

  6. Knockdown of MACF1 in osteoblastic cells inhibits osteoblast differentiation through suppressing the beta-catenin/TCF1-Runx2 axis.

  7. a disruption of trafficking across microtubles to actin filaments underlies the ciliogenesis defect in cells lacking MACF1.

  8. Cell counting revealed significant decrease of cell proliferation and cell cycle analysis showed an S phase cell cycle arrest in MACF1-knockdown cells.

  9. Data show that microtubule actin crosslinking factor 1 (MACF1) determines neuronal positioning by regulating microtubule dynamics and mediating glycogen synthase kinase 3 (GSK-3) signaling during brain development.

  10. data identify for the first time, a role for MACF1 in cardiomyocyte microtubule distribution and in adaptation to hemodynamic overload

  11. Studied ACF7 and paracellular permeability, by conditional knock out of ACF7 in the intestinal mucosa of mice. Findings indicated that ACF7 deficiency resulted in significant interstitial proliferation and columnar epithelial cell rearrangement.

  12. ACF7 is a linker protein that helps to shape the cytoskeleton of the hair cell during early hair-bundle genesis.

  13. Study identified a link between GSK3beta and ACF7 and further reveal the in vivo relevance of this connection in polarized locomotion of skin stem cells upon injury.

  14. Our data suggest a critical role for MACF1 in neuronal migration that is dependent on its ability to interact with both microfilaments and microtubules.

  15. In ACF7's absence, microtubules still bind EB1 and CLIP170, but they no longer grow along polarized actin bundles, nor do they pause and tether to actin-rich cortical sites.

  16. a new role of MACF1 in the Wnt signaling pathway, MACF1 was highly expressed in neuronal tissues and the foregut of embryonic day 8.5 (E8.5) embryos and the head fold and primitive streak of E7.5 embryos.

  17. ACF7 deficiency compromises the targeting of microtubules along F-actin to focal adhesions (FAs), stabilizes FA-actin networks, and impairs epidermal migration.

  18. In conclusion, LG-HMF affects osteoblast-like cell viability, MACF1 distribution, expression, and its association with cytoskeleton to some extent.

  19. Mouse ACF7 and Drosophila Short stop modulate filopodia formation and microtubule organisation during neuronal growth.

MACF1 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the plakin family of cytoskeletal linker proteins. This protein family forms bridges between different cytoskeletal elements through specialized modular domains. The encoded protein is one of the largest size proteins identified in human cytoskeletal proteins. It has functional actin and microtubule binding domains, and it appears to stabilize actin at sites where microtubules and microfilaments meet. It may function in microtubule dynamics to facilitate actin-microtubule interactions at the cell periphery and to couple the microtubule network to cellular junctions. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with MACF1

  • microtubule-actin crosslinking factor 1 (MACF1) antibody
  • microtubule-actin crosslinking factor 1a (macf1a) antibody
  • microtubule-actin crosslinking factor 1 (macf1) antibody
  • microtubule-actin cross-linking factor 1 (LOC100175356) antibody
  • dual specificity protein kinase CLK3 (LOC100514848) antibody
  • microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (LOC100550622) antibody
  • microtubule-actin crosslinking factor 1 (Macf1) antibody
  • ABP620 antibody
  • Acf7 antibody
  • Aclp7 antibody
  • DKFZp469K2016 antibody
  • fc46g01 antibody
  • MACF antibody
  • MACF1 antibody
  • mKIAA0465 antibody
  • OFC4 antibody
  • R74989 antibody
  • si:rp71-45k5.7 antibody
  • wu:fc46g01 antibody

Protein level used designations for MACF1

microtubule-actin crosslinking factor 1 , microfilament and actin filament cross-linker protein , actin-crosslinking protein , magellan , mgn , microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 , Microtubule-actin cross-linking factor 1-like , microtubule-actin cross-linking factor 1, isoforms 1/2/3/5-like , 620 kDa actin binding protein , actin cross-linking family protein 7 , macrophin 1 , microtubule-actin cross-linking factor 1 , trabeculin-alpha , actin cross-linking family 7 , actin-crosslinking protein 7 , trabeculin alpha

419671 Gallus gallus
456778 Pan troglodytes
475321 Canis lupus familiaris
506730 Bos taurus
562190 Danio rerio
100025003 Monodelphis domestica
100068727 Equus caballus
100127846 Xenopus (Silurana) tropicalis
100173160 Pongo abelii
100175356 Ciona intestinalis
100341624 Oryctolagus cuniculus
100479117 Ailuropoda melanoleuca
100514848 Sus scrofa
100550622 Meleagris gallopavo
23499 Homo sapiens
11426 Mus musculus
362587 Rattus norvegicus
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