Microtubule-Associated Protein, RP/EB Family, Member 2 Proteins (MAPRE2)

The protein encoded by MAPRE2 shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. Additionally we are shipping Microtubule-Associated Protein, RP/EB Family, Member 2 Antibodies (110) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MAPRE2 10982 Q15555
MAPRE2 212307 Q8R001
MAPRE2 679221 Q3B8Q0
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Top Microtubule-Associated Protein, RP/EB Family, Member 2 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,227.64
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,227.64
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
Yeast Rat His tag   1 mg 60 to 71 Days
$2,876.50
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Yeast Cow His tag   1 mg 60 to 71 Days
$2,876.50
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Yeast Xenopus laevis His tag   1 mg 60 to 71 Days
$2,880.17
Details
Escherichia coli (E. coli) Human His tag 100 μg 15 to 19 Days
$553.85
Details

MAPRE2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Microtubule-Associated Protein, RP/EB Family, Member 2 (MAPRE2) Interaction Partners

Human Microtubule-Associated Protein, RP/EB Family, Member 2 (MAPRE2) interaction partners

  1. Aurora B and CDK1 temporally regulate the binding affinity of EB2 for microtubules, thereby ensuring kinetochore microtubule dynamics, proper mitotic progression and genome stability.

  2. Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type.

  3. EB2 is evidently important for initial microtubule reorganisation during epithelial polarisation, whereas its downregulation facilitates EB1 and ACF7 microtubule lattice association, microtubule-actin filament co-alignment and bundle formation.

  4. results suggest that EB1 and ClipCG12 act cooperatively to regulate microtubule dynamics (EB1)

  5. heterodimer formation between EB1 and EB3, but not between EB2 and the other two EBs, occurs both in vitro and in cells as revealed by live cell imaging

  6. Data suggest that a functional interaction between EB1 and p150(Glued) is required for microtubule minus end anchoring at centrosomes during the assembly and maintenance of a radial microtubule array.

  7. EB1 may modulate kinetochore microtubule polymerization and/or attachment

  8. results support the novel hypothesis that EB1 overexpression may play a role in the development of esophageal squamous cell carcinoma by affecting APC function and activating the beta-catenin/TCF pathway

  9. Impaired EB1 or APC function generates lesions invisible to the spindle checkpoint and thereby promotes low levels of chromosomal loss (CIN) expected to fuel aneuploidy and possibly tumorigenesis.

  10. These data demonstrate that the COP9 signalosome-dependent protection of EB1 is important for microtubule function.

  11. Crystal structures of the tubulin binding domains of XMAP215 (yeast Stu2p and Drosophila Msps), EB1 (yeast Bim1p and human EB1), and CLIP-170 (human), which reveal diverse tubulin binding interfaces, are reported.

  12. p150Glued may activate and thereby facilitate the recruitment of EB1 to the tips of microtubules to regulate their dynamics.

  13. EB1-tubulin interactions are mediated in part by the same tubulin acidic tails utilized by other MAPs

  14. MAPRE2 is highly expressed in pancreatic cancer cells, and seems to be involved in perineural invasion

Mouse (Murine) Microtubule-Associated Protein, RP/EB Family, Member 2 (MAPRE2) interaction partners

  1. Knockdown of HAX1 and EB2 in skin epidermal cells stabilizes focal adhesions and impairs epidermal migration.

  2. Thus, we suggest that EB1 could complement MAP1B function during neural development.

Microtubule-Associated Protein, RP/EB Family, Member 2 (MAPRE2) Protein Profile

Protein Summary

The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with MAPRE2

  • microtubule associated protein RP/EB family member 2 (MAPRE2)
  • microtubule-associated protein, RP/EB family, member 2 (Mapre2)
  • microtubule associated protein RP/EB family member 2 S homeolog (mapre2.S)
  • AI314113 protein
  • C820009F03Rik protein
  • D18Abb1e protein
  • DKFZp459O163 protein
  • EB1 protein
  • EB2 protein
  • MAPRE2 protein
  • mapre2-A protein
  • RP1 protein

Protein level used designations for MAPRE2

microtubule-associated protein, RP/EB family, member 2 , Microtubule-associated protein RP/EB family member 2 , APC-binding protein EB1 , APC-binding protein EB2 , T-cell activation protein, EB1 family , end-binding protein 2 , microtubule-associated protein RP/EB family member 2 , T-cell activation protein, EB1 family, member 2

GENE ID SPECIES
455369 Pan troglodytes
100173979 Pongo abelii
100227855 Taeniopygia guttata
10982 Homo sapiens
212307 Mus musculus
679221 Rattus norvegicus
510159 Bos taurus
421105 Gallus gallus
490487 Canis lupus familiaris
373805 Xenopus laevis
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