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Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Additionally we are shipping Microtubule-Associated Protein, RP/EB Family, Member 3 Proteins (9) and many more products for this protein.
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Human Polyclonal MAPRE3 Primary Antibody for ELISA, WB - ABIN4306832
Komarova, De Groot, Grigoriev, Gouveia, Munteanu, Schober, Honnappa, Buey, Hoogenraad, Dogterom, Borisy, Steinmetz, Akhmanova: Mammalian end binding proteins control persistent microtubule growth. in The Journal of cell biology 2009
One candidate pathway coupling actin filaments to microtubules consists of the actin filament-binding protein drebrin (show DBN1 Antibodies) and the microtubule-binding +TIP protein EB3. This pathway is regulated proximally by cyclin-dependent kinase 5 (show CDK5 Antibodies) phosphorylation of drebrin (show DBN1 Antibodies) but the upstream elements in the pathway have yet to be identified.
EB1 (show MAPRE2 Antibodies) and EB3 thus affect multiple interphase processes and have a major impact on microtubule minus end organization.
Findings show that co-ordination of dynamic microtubules and actin filaments by the drebrin (show DBN1 Antibodies)/EB3 pathway drives prostate cancer cell invasion and is therefore implicated in disease progression.
Aptamers binding to human EB1 (show MAPRE2 Antibodies) and EB3, which have sequence requirements similar to but distinct from each other and from Drosophila EB1 (show MAPRE2 Antibodies), were identified.
EB1 (show MAPRE2 Antibodies) and EB3 proteins are obligatory dimers.
Findings suggest that methylation-associated down-regulation of EBF3 and IRX1 (show IRX3 Antibodies) genes may play an important role in a pathogenic effect of TGF-beta (show TGFB1 Antibodies) on RASFs.
Daughter cell adhesion and cytokinesis completion are spatially regulated by distinct states of EB3 phosphorylation on serine 176 by Aurora B (show AURKB Antibodies).
decreasing the drebrin E (show DBN1 Antibodies) levels disrupted the normal subapical F-actin-myosin-IIB (show MYH10 Antibodies)-betaII-spectrin network and the apical accumulation of EB3, a microtubule-plus-end-binding protein
VE-cadherin (show CDH5 Antibodies) outside-in signaling regulates cytosolic calcium homeostasis and EB3 phosphorylation.
Data indicated that EB1 (show MAPRE2 Antibodies) and EB3 interact with proteins implicated in MT minus-end anchoring or vesicular trafficking to the cilia base, suggesting that EB1 (show MAPRE2 Antibodies) and EB3 promote ciliogenesis by facilitating such trafficking.
EB3 binds to IP3 receptors, promotes IP3R (show ITPR1 Antibodies) clustering and Ca2 (show CA2 Antibodies)+ signals in endothelial cells.
MAP1B (show MAP1B Antibodies) interacts directly with EB1 (show MAPRE1 Antibodies) and EB3 (EBs), two core 'microtubule plus-end tracking proteins' ( TIPs), and sequesters them in the cytosol of developing neuronal cells.
DDA3 (show PSRC1 Antibodies) is a novel microtubule-associated protein (show SPAG5 Antibodies) that binds to EB3, and results implicate DDA3 (show PSRC1 Antibodies) and EB3 in the beta-catenin (show CTNNB1 Antibodies)-mediated growth signaling.
Two +TIPs, CLIP-170 (show CLIP1 Antibodies) and end-binding protein 3 (EB3), turn over rapidly on MT ends. Diffusion of CLIP-170 (show CLIP1 Antibodies) and EB3 appears to be rate limiting for their binding to MT plus ends.
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).
microtubule-associated protein, RP/EB family, member 3
, APC binding protein
, EB1 protein family member 3
, end-binding protein 3
, microtubule-associated protein RP/EB family member 3