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The protein encoded by MID2 is a member of the tripartite motif (TRIM) family. Additionally we are shipping Midline 2 Proteins (5) and Midline 2 Kits (2) and many more products for this protein.
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Human Polyclonal MID2 Primary Antibody for IHC (p), IHC - ABIN249758
Buchner, Montini, Andolfi, Quaderi, Cainarca, Messali, Bassi, Ballabio, Meroni, Franco: MID2, a homologue of the Opitz syndrome gene MID1: similarities in subcellular localization and differences in expression during development. in Human molecular genetics 1999
Mid2 regulates cell division through the ubiquitination of astrin (show SPAG5 Antibodies) on K409, which is critical for its degradation and proper cytokinesis.
A novel missense mutation (c.1040G>A, p.Arg347Gln) was reported in MID2, which encodes ubiquitin ligase E3, as the likely cause of X-linked mental retardation in a large kindred.
MID2 coiled-coil motifs mediate both homo- and heterodimerization, a prerequisite for association of the MID-alpha 4 complex with microtubules.
MID2 is a candidate gene for FG syndrome.
both MID1 (show MID1 Antibodies) and MID2 play a central role in the regulation of granule exocytosis and that functional redundancy exists between MID1 (show MID1 Antibodies) and MID2 in cytotoxic T cells
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
, ubiquitin ligase
, RING finger protein 60
, midin 2
, midline defect 2
, probable E3 ubiquitin-protein ligase MID2
, tripartite motif protein 1
, tripartite motif-containing protein 1