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Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Additionally we are shipping Mitochondrially Encoded NADH Dehydrogenase 1 Antibodies (55) and Mitochondrially Encoded NADH Dehydrogenase 1 Proteins (9) and many more products for this protein.
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This review focuses on the role of mitochondrial genes in causing LHON and therapeutics available for treating the disease. A systematic search has been adopted in various databases using the keywords "LHON," "mitochondria," "ND1," "ND4," "ND6 (show MT-ND6 ELISA Kits)," and "therapy" and the following review on mitochondrial genetics.
The MT-ND1 m.3635G>A mutation has resulted in decreased efficiency of ATP synthesis.
the MT-ND1 gene is a hot spot for mutations associated with LHON.
ND1 genetic polymorphisms associated with breast cancer in Mizoram mongloid population.
The present study revealed no association between MS and T4216C variation in the ND1 mtDNA gene in the Iranian population.
ND1 T3866C mutation is associated with Chinese families with Leber's hereditary optic neuropathy.
To investigate the pathophysiology of Leber's hereditary optic neuropathy (LHON), a cohort of 1164 Han Chinese subjects with LHON were screened for ND1 G3460A mutation.
m.3460G>A/MT-ND1 mutation caused only a reduction in mitochondrial complex I(CI) activity, whereas the m.3571insC/MT-ND1 and the m.3243A>G/MT-TL1 (show TNFSF15 ELISA Kits) mutations induced a severe structural and functional CI alteration.
Novel mutations m.3959G>A and m.3995A>G in mitochondrial gene MT-ND1 associated with MELAS.
In Sherpa people, 2 mutations are ND1 mutants. One of them was reported as the primary mutation for Leber's hereditary optic neuropathy suggesting a certain effect on Complex I function and might be important in the altitude adaptation for Sherpa people.
miR (show MLXIP ELISA Kits)-30a-5p ameliorates inflammatory responses and oxidative stress by targeting Neurod 1 through MAPK/ERK (show MAPK1 ELISA Kits) signalling
Retinoid acid (RA) and taurine further improved the differentiation efficiency of iPSCs overexpressing NeuroD1. However, RA and taurine did not promote differentiation in the absence of NeuroD1 overexpression.
Environmental enrichment enhances dorsal-ventral differences in DNA methylation, including at binding sites of the transcription factor NeuroD1, a regulator of adult neurogenesis.
ASCL1 and NEUROD1 distinguish heterogeneity in SCLC with distinct genomic landscapes.
The results of this study reveal essential roles for Neurod1 (show NEUROD1 ELISA Kits) and Neurod6 (show NEUROD6 ELISA Kits) in the survival of these neurons during development.
it is suggested that the suppression of NeuroD1 (show NEUROD1 ELISA Kits) expression and the inhibition of NeuroD1 (show NEUROD1 ELISA Kits)/E-box interaction may play an important role in the Gc-mediated negative regulation of Pomc (show POMC ELISA Kits).
Wnt3a increased the expression of NeuroD1 and Ins2 in the hypothalamus.
The authors show that NeuroD1 directly binds regulatory elements of neuronal genes that are developmentally silenced by epigenetic mechanisms.
Expression of Transcription Factor NeuroD1 in Olfactory Bulb Glutamatergic Neurons
Data show that RNA binding protein HuD and special adenine-thymine (AT)-rich DNA-binding protein 1 (SATB1) form a positive regulatory loop that enhances NeuroD1 protein transcription and subsequent neuronal differentiation.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
NADH dehydrogenase subunit 1
, beta-cell E-box transcriptional activator 2
, neurogenic differentiation factor 1
, NADH-ubiquinone oxidoreductase chain 1
, PPIase A
, cyclophilin A
, cyclosporin A-binding protein
, peptidyl-prolyl cis-trans isomerase A
, rotamase A