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activity; localization, and function is regulated by the C-terminal tail.
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CapZIP (show RCSD1 ELISA Kits), which has been shown to regulate ciliogenesis, is an ERK7 substrate, and that Dishevelled, which has also been shown to regulate ciliogenesis, facilitates ERK7 phosphorylation of CapZIP (show RCSD1 ELISA Kits) through binding to both ERK7 and CapZIP (show RCSD1 ELISA Kits).
High MAPK15 expression is associated with male germ cell tumors.
In HeLa cells, phosphorylation of HuR (show ELAVL1 ELISA Kits) by ERK8 prevents it from binding to PDCD4 (show PDCD4 ELISA Kits) mRNA and allows miR (show MLXIP ELISA Kits)-21-mediated degradation of PDCD4 (show PDCD4 ELISA Kits).
depletion of endogenous MAPK15 expression inhibited BCR (show BCR ELISA Kits)-ABL1 (show ABL1 ELISA Kits)-dependent cell proliferation, in vitro
The present study suggests that MAPK15 overexpression may contribute to the malignant transformation of gastric mucosa by prolonging the stability of c-Jun (show JUN ELISA Kits).
ERK8 appears as a constitutive brake on N-Acetylgalactosaminyltransferase (show B4GALNT2 ELISA Kits) relocalisation, and the loss of its expression could drive cancer aggressivity through increased cell motility.
Data suggest that the model coulb be a tool for the development of specific ERK8 kinase inhibitors.
ATG8 (show GABARAPL2 ELISA Kits)-like proteins (MAP1LC3B (show MAP1LC3B ELISA Kits), GABARAP (show GABARAP ELISA Kits) and GABARAPL1) are novel interactors of MAPK15/ERK8, a MAP kinase (show MAPK1 ELISA Kits) involved in cell proliferation and transformation.
a novel function for ERK8 as a bona fide ERRalpha (show ESRRA ELISA Kits) corepressor, involved in control of its cellular localization by nuclear exclusion, and suggest a key role for this MAP kinase (show MAPK1 ELISA Kits) in the regulation of the biological activities of this nuclear receptor.
Data show that ERK8 prevents HDM2-mediated PCNA (show PCNA ELISA Kits) destruction by inhibiting the association of PCNA (show PCNA ELISA Kits) with HDM2, and implicate ERK8 in the regulation of genomic stability.
Extracellular signal-regulated kinase 8-mediated c-Jun (show JUN ELISA Kits) phosphorylation increases tumorigenesis of human colon cancer
Taken together, our results suggest that ERK8 plays an important role in spindle organization during mouse oocyte meiotic maturation and early embryo cleavage.
Erk8 has a role as a novel effector of RET (show RET ELISA Kits)/PTC3 and, therefore, RET (show RET ELISA Kits) biological functions
activity\; localization, and function is regulated by the C-terminal tail
mitogen-activated protein kinase 15
, extracellular signal-regulated kinase 7
, MAP kinase 15
, MAPK 15
, extracellular regulated kinase 8 delta
, extracellular signal regulated kinase 8
, extracellular signal-regulated kinase 8