anti-Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) Antibodies

ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). Additionally we are shipping ZAK Proteins (9) and ZAK Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ZAK 311743  
ZAK 51776 Q9NYL2
ZAK 65964 Q9ESL4
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Top anti-ZAK Antibodies at antibodies-online.com

Showing 10 out of 99 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IC, IF, WB Immunofluorescent analysis of ZAK staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of ZAK expression in HeLa (A), HepG2 (B), NIH3T3 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-MLKLAK-C284 Pab (ABIN392643) in HepG2 cell line lysate (35 µg/lane). MLKLAK-C284(arrow) was detected using the purified polyclonal antibody (1:60 dilution). This western blot detected isoform 2 of MLKLAK, the accession number for MLKLAK isoform 1 is Q9NYL2, NP_057737. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB 100 μL Log in to see 8 to 11 Days
$516.98
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from HeLa cells, using MLTK Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using MLTK Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from Jurkat cells, using ZAK (Ab-165) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: ZAK Antibody  - Analysis in human cell line U-138 MG. Immunocytochemistry/Immunofluorescence: ZAK Antibody  - Immunofluorescent staining of human cell line A-431 shows localization to cytosol. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: A549 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated ELISA, IF, WB 100 μL Log in to see Available
$181.73
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to ZAK on formalin-fixed paraffin-embedded human prostate. [antibody concentration 3 ug/ml] ZAK monoclonal antibody (M03), clone 3G5. Western Blot analysis of ZAK expression in human stomach. 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of ZAK (Phospho-Ser165) using HeLa whole cell lysates 100 μL Log in to see 11 to 12 Days
$450.00
Details

Top referenced anti-ZAK Antibodies

  1. Human Polyclonal ZAK Primary Antibody for IHC (p), ELISA - ABIN544235 : Jhiang: The RET proto-oncogene in human cancers. in Oncogene 2000 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal ZAK Primary Antibody for IF, IHC (p) - ABIN565679 : Cariolato, Cavin, Diviani: A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in ?1-adrenergic receptor-induced p38 activation. in The Journal of biological chemistry 2011 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal ZAK Primary Antibody for ICC, IF - ABIN4366552 : Liu, McCleland, Stawiski, Gnad, Mayba, Haverty, Durinck, Chen, Klijn, Jhunjhunwala, Lawrence, Liu, Wan, Chopra, Yaylaoglu, Yuan, Ha, Gilbert, Reeder, Pau, Stinson, Stern, Manning, Wu, Neve et al.: Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer. ... in Nature communications 2014 (PubMed)

  4. Human Polyclonal ZAK Primary Antibody for IHC (p), WB - ABIN392643 : Blume-Jensen, Hunter: Oncogenic kinase signalling. in Nature 2001 (PubMed)
    Show all 2 Pubmed References

More Antibodies against ZAK Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) interaction partners

  1. The ZAK rs3769201 and rs722864 may be functional susceptibility loci for lung cancer risk.

  2. The expression of ZAKbeta is dependent on ZAKalpha expression, and ZAKbeta further enhances ZAKalpha expression and results in synergistic enhancement of apoptosis in osteosarcoma cells.

  3. Gene set enrichment analysis disclosed a significant correlation between ZAK+ colorectal premalignant lesions and gene sets belonging to the MAPK/ERK and motility-related signaling pathways of the reactome database, strongly suggesting that ZAK induces such pro-tumoral reaction cascades in human cancers.

  4. Recessive mutations in the kinase ZAK - novel cause of congenital myopathy.

  5. ZAK is a key player in mammalian limb patterning in humans and mice.

  6. ZAK kinase isoform TV1 is preferentially upregulated in gastric tumours and cell lines relative to normal samples. This pattern is also observed in colorectal, bladder and breast cancers.

  7. The long non-coding RNA URHC promotes cell proliferation and inhibits apoptosis by repressing ZAK expression through inactivation of the ERK/MAPK pathway.

  8. we report that sorafenib suppresses UV-induced apoptosis specifically by inhibiting c-jun-NH(2)-kinase (JNK) activation through the off-target inhibition of leucine zipper and sterile alpha motif-containing kinase (ZAK)

  9. MRK is a novel RhoC effector that controls LPA-stimulated cell invasion at least in part by regulating myosin dynamics, ERK and p38

  10. The genes identified KTN1, ROCK1, and ZAK may be responsible for loss of cellular homeostasis in giant cells tumors of bone

  11. decrease of lung cancer cell proliferation by ZAK may involve the ERK and JNK pathways via an AP-1 transcription factor.

  12. In this study, by applying a novel method, we have identified the phosphorylation sites in human MSK1 mitogen- and stress-activated protein kinase 1, and show that MRK-beta could also activate MSK1 through direct interaction.

  13. Results suggest that ZAK might play a role as an upstream signal to suppress the ZZaPK function and decrease E2F expression.

  14. Data show that in response to radiation, MRK controls two independent pathways: the Chk2-Cdc25A pathway leading to cell cycle arrest and the p38gamma MAPK pathway

  15. Results suggest that a ZAK mediates TGF-beta-induced cardiac hypertrophic growth via a novel TGF-beta signaling pathway.

  16. ZAK induces characteristic hypertrophic growth features, including increased cell size, elevated atrial natriuretic factor expression, and increased actin fiber organization

  17. Mixed lineage kinase 7 (MLK7), a splice variant of the ZAK gene, encodes an isoform which is the MAPKKK required for modulation of the stress-activated MAPKs downstream of anisomycin and UV stimulation.

  18. data demonstrate that a ZAK isoform(s) is the MAP3Kinase that transduces the ribotoxic stress response

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) interaction partners

  1. Zak-/- mice demonstrate a distinct ribotoxic stress-associated phenotype in response to ricin.

  2. ZAK is a key player in mammalian limb patterning in humans and mice.

  3. Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6, Zak, Gpr155, and Mtx2) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions.

  4. PKNalpha functions as not only an upstream activator of MLTKalpha but also a putative scaffold protein for the p38gamma MAPK signaling pathway

  5. Results show that mixed lineage kinase-like mitogen-activated protein triple kinase (MLTK_-alpha plays a key role in the UVB- and EGF-induced phosphorylation of histone H3 at Ser28.

  6. Mixed lineage kinase 7 (MLK7), a splice variant of the human ZAK gene (ortholog of mouse B230120H23Rik), encodes an isoform which is the MAPKKK required for modulation of the stress-activated MAPKs downstream of anisomycin and UV stimulation.

ZAK Antigen Profile

Protein Summary

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with ZAK

  • mitogen-activated protein kinase kinase kinase 20 (Map3k20) antibody
  • mitogen-activated protein kinase kinase kinase 20 (MAP3K20) antibody
  • AV006891 antibody
  • AZK antibody
  • B230120H23Rik antibody
  • MLK7 antibody
  • mlklak antibody
  • MLT antibody
  • MLTK antibody
  • MLTKalpha antibody
  • MLTKbeta antibody
  • MRK antibody
  • pk antibody
  • RGD1561394 antibody

Protein level used designations for ZAK

mitogen-activated protein kinase kinase kinase MLT , HCCS-4 , MLK-like mitogen-activated protein triple kinase , human cervical cancer suppressor gene 4 protein , mixed lineage kinase 7 , mixed lineage kinase with a leucine zipper and a sterile alpha motif , mixed lineage kinase-related kinase MRK-beta , MLK-related kinase , MRK , leucine zipper- and sterile alpha motif kinase ZAK , mixed lineage kinase-related kinase , sterile alpha motif- and leucine zipper-containing kinase AZK , sterile-alpha motif and leucine zipper containing kinase AZK

GENE ID SPECIES
311743 Rattus norvegicus
51776 Homo sapiens
65964 Mus musculus
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