ZAK Products
(Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK))
Categories
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
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Featured ZAK Categories
ZAK Antibodies
High quality antibodies with extensive validation data.
ZAK ELISA Kits
Reliable ELISA kits for a wide range of species.
ZAK Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ZAK Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (3)
- (5)
Cat. No.
ABIN565679
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (4)
Cat. No.
ABIN6150360
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (1)
- (2)
Cat. No.
ABIN392643
Quantity
400 μL
Datasheet
Datasheet
Recommended ZAK ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN5595441
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1142997
Quantity
96 tests
Datasheet
Datasheet
Recommended ZAK Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (2)
Cat. No.
ABIN1325564
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5570540
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325566
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our ZAK products
: "NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II." in: Cell death & disease, Vol. 7, Issue 8, pp. e2346, (2017) (PubMed).: "A Requirement for ZAK Kinase Activity in Canonical TGF-β Signaling." in: Translational oncology, Vol. 9, Issue 6, pp. 473-481, (2016) (PubMed).
: "Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer. ..." in: Nature communications, Vol. 5, pp. 3830, (2014) (PubMed).
: "A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy." in: Molecular and cellular biology, Vol. 33, Issue 15, pp. 2903-17, (2013) (PubMed).
: "A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in ?1-adrenergic receptor-induced p38 activation." in: The Journal of biological chemistry, Vol. 286, Issue 10, pp. 7925-37, (2011) (PubMed).
: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).
: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, (2001) (PubMed).
: "The RET proto-oncogene in human cancers." in: Oncogene, Vol. 19, Issue 49, pp. 5590-7, (2000) (PubMed).
Synonyms and alternative names related to ZAK
mitogen-activated protein kinase kinase kinase 20 (Map3k20), mitogen-activated protein kinase kinase kinase 20 (MAP3K20), AV006891, AZK, B230120H23Rik, MLK7, mlklak, MLT, MLTK, MLTKalpha, MLTKbeta, MRK, pk, RGD1561394Protein level used designations for ZAK
- mitogen-activated protein kinase kinase kinase MLT
- HCCS-4
- MLK-like mitogen-activated protein triple kinase
- human cervical cancer suppressor gene 4 protein
- mixed lineage kinase 7
- mixed lineage kinase with a leucine zipper and a sterile alpha motif
- mixed lineage kinase-related kinase MRK-beta
- MLK-related kinase
- MRK
- leucine zipper- and sterile alpha motif kinase ZAK
- mixed lineage kinase-related kinase
- sterile alpha motif- and leucine zipper-containing kinase AZK
- sterile-alpha motif and leucine zipper containing kinase AZK
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