Mucin 5 Subtype B Proteins (MUC5B)

MUC5B encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. Additionally we are shipping MUC5B Antibodies (91) and MUC5B Kits (56) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MUC5B 727897 Q9HC84
MUC5B 309114  
MUC5B 74180  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top MUC5B Proteins at antibodies-online.com

Showing 5 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Mouse His tag 100 μg 15 to 18 Days
$768.00
Details
Escherichia coli (E. coli) Rat His tag,GST tag 100 μg 15 to 18 Days
$746.00
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human Mucin 5B Protein. 100 μg 11 to 18 Days
$682.25
Details
Escherichia coli (E. coli) Cow T7 tag,His tag 100 μg 15 to 18 Days
$784.00
Details

MUC5B Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for Mucin 5 Subtype B (MUC5B) Interaction Partners

Human Mucin 5 Subtype B (MUC5B) interaction partners

  1. MUC5B defective unfolding/maturation process after granular release suggests that the cystic fibrosis extracellular environment is ion/water depleted and likely contributes to abnormal mucus properties in cystic fibrosis airways prior to infection and inflammation

  2. The MUC5B (mucin 5B, oligomeric mucus/gel-forming) gene encodes respiratory tract mucin glycoproteins that play a role in mucociliary clearance and host defense.

  3. Level of Mucin 5B was significantly higher in serum of oral lichen planus (OLP).

  4. MUC5B promoter variant is associated with higher C3 expression and suggest that the complement system may contribute to the pathogenesis of idiopathic pulmonary fibrosis.

  5. MUC5B and CA9 are highly conserved during gallbladder cance rhistological progression

  6. reduced salivary concentration linked to dental caries

  7. MUC5B-related and telomerase-related mechanisms of Idiopathic pulmonary fibrosis pathogenesis might yield a common clinical diathesis via distinct pathogenic routes with implications for clinical trial design and patient management.

  8. the single CYS domain and the two CYS domains of mini-5B mucin must be C-mannosylable for the efficient maturation and secretion of the recombinant molecules.

  9. The MUC5B promoter polymorphism may have a beneficial effect on the risk of acute respiratory disease events in smokers with interstitial CT features.

  10. Study findings suggest that mucociliary dysfunction might play a causative role in bleomycin-induced pulmonary fibrosis in mice overexpressing Muc5b, and that MUC5B in distal airspaces is a potential therapeutic target in humans with idiopathic pulmonary fibrosis.

  11. We found that the MUC5B promoter variant was associated with rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) and more specifically associated with evidence of usual interstitial pneumonia on imaging.

  12. the combination of intracellular packing of the MUC5B mucin and the submucosal gland morphology creates an efficient machine for producing linear mucin bundles.

  13. resistin induced MUC5AC and MUC5B expression via activation of different signaling pathways in human airway epithelial cells.

  14. Genetic variations in the MUC5B gene can influence dental caries.

  15. The expression of MUC5B mRNA increased with increases in NH concentration, and was significantly higher compared to that in untreated cells. H. pylori may affect the expression of MUC5AC, MUC2, MUC5B, and MUC6 in AGS cells via CagA and/or NH, but not E-cadherin.

  16. MUC5B was identified as PRP-1 receptor in human chondrosarcoma JJ012 cell line using Ligand-receptor capture technology.

  17. The MUC5B promoter polymorphism is strongly associated with interstitial lung abnormalities and specific radiologic subtypes of ILA, with varying degrees of heterogeneity in the underlying populations

  18. The associations between MUC5B rs35705950 and short telomere length with extent of fibrosis, histopathological features of usual interstitial pneumonia, and reduced survival in patients with chronic hypersensitivity pneumonitis suggest shared pathobiology with IPF, and might help to stratify risk.

  19. High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells

  20. IL-33 induced MUC5AC mRNA and MUC5AC protein, and also goblet cell hyperplasia at air liquid interface culture in human nasal epithelial cells. In addition to that, IL-33 induced MUC5B and FOXA3, and reduces FOXJmRNA.

Mouse (Murine) Mucin 5 Subtype B (MUC5B) interaction partners

  1. MUC5B promoter variant is associated with higher C3 expression and suggest that the complement system may contribute to the pathogenesis of idiopathic pulmonary fibrosis.

  2. that Spdef regulates baseline Muc5b expression in respiratory epithelia but does not contribute to Muc5b regulation in a mouse model of Muc5b-predominant mucus obstruction caused by airway dehydration

  3. Study findings suggest that mucociliary dysfunction might play a causative role in bleomycin-induced pulmonary fibrosis in mice overexpressing Muc5b, and that MUC5B in distal airspaces is a potential therapeutic target in humans with idiopathic pulmonary fibrosis.

  4. The transgenic Muc5b-GFP mouse is unique and suitable to study the mechanisms that regulate Muc5b production/secretion and mucous cell differentiation by live imaging and can be applied to test drug efficacy in mucosal disease models

  5. absence of Muc5b in knock-out mice caused a 90% reduction in mucociliary clearance

  6. These results reveal distinct morphology and interactions for MUC5B and MUC5AC and suggest that the two mucins make distinct contributions to mucociliary transport.

  7. The decrease density of mucin-5B (Muc5b+) conjunctival goblet cell population in the dry eye syndrome (DES) model reflects the whole conjunctival goblet cell loss, indicating Muc5b is a biological marker of DES models.

  8. Reduced levels of Muc5b in aged mice may be contribute to decreased mucociliary clearance.

  9. Both compounds down regulated mucin 5 subtype B, and peptidoglycan recognition protein 1 in vaginal tissue

  10. Expressions of Orai1, Muc5b, IL-4, IL-5, IL-13 and IL-33 were up-regulated in the allergic state and IL-33 increased the levels of Muc5b, IL-4, IL-5 and IL-13, but did not influence proliferation of T cells.

  11. deleting either the Muc5ac or Muc5b gene is insufficient to create an observable dry eye phenotype on the ocular surface of these mice.

  12. mouse Muc5b (but not Muc5ac) is required for mucociliary clearance, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in mouse lungs, whereas Muc5ac is dispensable

  13. Muc5b was detected in all mammary tumors analyzed from MMTV-ras mice

  14. Muc5b is a target gene of transcription factors (TTF-1, GATA-6) involved in lung differentiation programs during development and carcinogenesis. TTF-1 is a strong repressor of Muc5b.

  15. analysis of Muc5ac and Muc5b production during prenatal and postnatal murine lung development

  16. Acidic pH drives middle ear epithelial Muc5b gene expression in vitro, which perhaps explains how laryngopharyngeal reflux can contribute to otitis media.

  17. The isolation and characterization of the mouse Muc5b mucin gene (mMuc5b), determined its complete cDNA sequence, its genomic organization, and chromosomal localization and expression.

  18. C-mannosylation is likely required for proper folding of the Cys subdomains and/or for some aspect of ER export during mucin biosynthesis

  19. organization of the secreted gel-forming mucin gene cluster and the complete gene structure of its different members

  20. MUC5B mucin gene contains several putative NF-kappa B sites in its promoter and is the predominant mucin expressed in human OM.

MUC5B Protein Profile

Protein Summary

This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases.

Gene names and symbols associated with Mucin 5 Subtype B Proteins (MUC5B)

  • mucin 5B, oligomeric mucus/gel-forming (MUC5B)
  • mucin 5B, oligomeric mucus/gel-forming (Muc5b)
  • mucin 5AC, oligomeric mucus/gel-forming (MUC5AC)
  • mucin 5B, oligomeric mucus/gel-forming (muc5b)
  • mucin-5B (LOC100498539)
  • mucin 5, subtype B, tracheobronchial (Muc5b)
  • 2300002I04Rik protein
  • A130042M24 protein
  • AV085033 protein
  • MG1 protein
  • MUC-5B protein
  • MUC5 protein
  • MUC5B protein
  • MUC9 protein
  • mucin 5b protein
  • RGD1561983 protein

Protein level used designations for Mucin 5 Subtype B Proteins (MUC5B)

cervical mucin MUC5B , high molecular weight salivary mucin MG1 , mucin 5, subtype B, tracheobronchial , mucin-5B , sublingual gland mucin , mucin 5B, oligomeric mucus/gel-forming , mucin protein , mucin 5, subtype B, tracheobronchial-like , mucin-5B-like

GENE ID SPECIES
727897 Homo sapiens
309114 Rattus norvegicus
483656 Canis lupus familiaris
720912 Macaca mulatta
100219137 Taeniopygia guttata
100332926 Danio rerio
100498539 Xenopus (Silurana) tropicalis
74180 Mus musculus
789503 Bos taurus
Selected quality suppliers for MUC5B Proteins (MUC5B)
Did you look for something else?