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anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) Antibodies

The protein encoded by MADCAM1 is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. Additionally we are shipping Mucosal Vascular Addressin Cell Adhesion Molecule 1 Kits (49) and Mucosal Vascular Addressin Cell Adhesion Molecule 1 Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MADCAM1 8174 Q13477
MADCAM1 17123  
MADCAM1 54266 O70540
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Top anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 Antibodies at antibodies-online.com

Showing 10 out of 185 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (fro), IHC (p), WB 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rat Un-conjugated BR, IAC, IHC (fro), FACS, IP, WB   0.5 mg Log in to see 15 to 18 Days
$351.64
Details
Mouse Rat Biotin FACS 500 μg Log in to see 10 to 12 Days
$285.74
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Mouse Rat Un-conjugated CyTOF, FACS 500 μg Log in to see 10 to 12 Days
$261.92
Details
Human Mouse APC FACS Detection of MAdCAM-1 in HeLa Human Cell Line by Flow Cytometry. HeLa human cervical epithelial carcinoma cell line was stained with Mouse Anti-Human MAdCAM-1 APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$393.30
Details
Human Mouse Un-conjugated ELISA, FACS, IHC, IHC (p), WB Human Colon (formalin-fixed, paraffin-embedded) stained with MADCAM1 antibody ABIN462006 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Human Spleen (formalin-fixed, paraffin-embedded) stained with MADCAM1 antibody ABIN462006 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 100 μg Log in to see 7 to 9 Days
$484.00
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Mouse Spleen Tissue; Lane2: Mouse Intestine Tissue; Lane3: Mouse Brain Tissue; Lane4: Mouse Liver Tissue. 100 μg Log in to see 13 to 16 Days
$342.00
Details
Mouse Rat Alexa Fluor 488 FACS   25 μg Log in to see 10 to 12 Days
$101.20
Details

Top referenced anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 Antibodies

  1. Mouse (Murine) Monoclonal MADCAM1 Primary Antibody for BR, IAC - ABIN967383 : Berg, McEvoy, Berlin, Bargatze, Butcher: L-selectin-mediated lymphocyte rolling on MAdCAM-1. in Nature 1994 (PubMed)
    Show all 11 Pubmed References

  2. Mouse (Murine) Monoclonal MADCAM1 Primary Antibody for BR, IAC - ABIN1176979 : Hänninen, Salmi, Simell, Andrew, Jalkanen: Recirculation and homing of lymphocyte subsets: dual homing specificity of beta 7-integrin(high)-lymphocytes in nonobese diabetic mice. in Blood 1996 (PubMed)
    Show all 9 Pubmed References

  3. Mouse (Murine) Monoclonal MADCAM1 Primary Antibody for FACS - ABIN2689831 : Berlin, Berg, Briskin, Andrew, Kilshaw, Holzmann, Weissman, Hamann, Butcher: Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. in Cell 1993 (PubMed)
    Show all 7 Pubmed References

  4. Mouse (Murine) Monoclonal MADCAM1 Primary Antibody for IHC (f), IHC (fro) - ABIN2689830 : Briskin, McEvoy, Butcher: MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1. in Nature 1993 (PubMed)
    Show all 4 Pubmed References

  5. Mouse (Murine) Monoclonal MADCAM1 Primary Antibody for IHC (f), IHC (fro) - ABIN2689829 : Streeter, Berg, Rouse, Bargatze, Butcher: A tissue-specific endothelial cell molecule involved in lymphocyte homing. in Nature 1988 (PubMed)
    Show all 3 Pubmed References

  6. Human Monoclonal MADCAM1 Primary Antibody for EIA, FACS - ABIN120238 : Leung, Lehnert, Kanwar, Yang, Mon, McNeil, Krissansen: Bioassay detects soluble MAdCAM-1 in body fluids. in Immunology and cell biology 2004 (PubMed)
    Show all 3 Pubmed References

  7. Human Monoclonal MADCAM1 Primary Antibody for EIA, FACS - ABIN320242 : Leung, Greene, Ni, Raymond, Lehnert, Langley, Krissansen: Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts. in Immunology and cell biology 1997 (PubMed)
    Show all 3 Pubmed References

  8. Human Monoclonal MADCAM1 Primary Antibody for ELISA, Func - ABIN2475465 : Herron: Selective nerve root block in patient selection for lumbar surgery: surgical results. in Journal of spinal disorders 1992 (PubMed)
    Show all 4 Pubmed References

  9. Human Monoclonal MADCAM1 Primary Antibody for ELISA, IHC (fro) - ABIN2475453 : Olloquequi, Montes, Prats, Rodríguez, Montero, García-Valero, Ferrer: Significant increase of CD57+ cells in pulmonary lymphoid follicles of COPD patients. in The European respiratory journal 2011 (PubMed)
    Show all 4 Pubmed References

More Antibodies against Mucosal Vascular Addressin Cell Adhesion Molecule 1 Interaction Partners

Human Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) interaction partners

  1. Both the ACT-1 (show TRAF3IP2 Antibodies) assay and the MAdCAM-1 assay demonstrated acceptable reproducibility and repeatability. The assays were sufficiently stable to allow for clinical use. During clinical testing the assays demonstrated that vedolizumab was able to saturate peripheral cells at all doses tested.

  2. Doxo-induced apoptosis has a role in inhibiting hepatocellular carcinoma by targeting Madcam1 and AKT (show AKT1 Antibodies) and blocking protein translation initiation

  3. MADCAM1 is up-regulated in liver cirrhosis with expression on peribiliary vascular plexus and lymphoid aggregates

  4. Domain 1 of mucosal addressin cell adhesion molecule (show MCAM Antibodies) has an I1-set fold and a flexible integrin-binding loop.

  5. Findings suggest that the inactive alpha4beta7 and alpha4beta7 activated by different stimuli have distinct conformations with different structural requirements for MAdCAM-1 binding.

  6. Ca2 (show CA2 Antibodies)+ is essential for cell tethering in flow and rolling interactions through alpha 4 integrins with MAdCAM-1 as substrate; Mg2 (show MUC7 Antibodies)+ promotes firm adhesion of cells on MAdCAM-1 but with much lower tethering efficiency in shear flow.

  7. A crystal structure for the two extracellular amino-terminal domains of human MAdCAM-1

  8. more extensive expression of MAdCAM-1 in Crohn's disease (CrD (show CRX Antibodies)), than in ulcerative colitis, which could contribute not only to mucosal inflammation, but also to transmural inflammation in CrD (show CRX Antibodies).

  9. MAdCAM-1/integrin alpha4beta7 homing system may participate in gastric inflammation in response to H pylori-infection and contributes to MALT formation, typically leading to the development of nodular gastritis.

  10. PI3-K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) is involved in the gut (show GUSB Antibodies)-specific differentiation of human intestinal microvascular endothelial cells, which results in expression of the mucosal addressin MAdCAM-1

Mouse (Murine) Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) interaction partners

  1. Loss of MAdCAM-1 has beneficial effects regarding the development of NASH (show SAMSN1 Antibodies) - manifested by reduced hepatic oxidative stress and decreased inflammation. In contrast, beta7-Integrin-deficiency results in increased steatohepatitis.

  2. The results uncovered a previously unknown role of integrin a4b7-MAdCAM-1 interactions as drivers of colitis by directing inflammatory monocytes into the colon.

  3. beta7 integrin, when expressed by hematopoietic stem cells (HSC (show FUT1 Antibodies)), interacted with its endothelial ligand MAdCAM-1 in the Bone marrow microenvironment, thereby promoting HSC (show FUT1 Antibodies) homing and engraftment.

  4. Nkx2-3 deficiency reprograms the endothelial addressin preference for lymphocyte homing in Peyer's patches.

  5. findings indicate that alpha4beta7*IgG can be used as a probe for functional MAdCAM-1 expressed on HEVs in GALT (show GALT Antibodies) and could potentially serve as an anti-inflammatory drug inhibiting GALT (show GALT Antibodies)-specific lymphocyte migration

  6. ectopic expression of MAdCAM-1 at the BBB does not increase alpha4beta7-integrin-mediated immune cell trafficking into the CNS during MOG(aa35-55)-induced experimental autoimmune encephalomyelitis

  7. Observed a significant decrease in expression of ICAM-1 (show ICAM1 Antibodies) and MAdCAM-1 mRNA/protein in lactobacillus plantarum treated colitis.

  8. results suggest that AT1R (show AGTRAP Antibodies) regulates the expression of MAdCAM-1 under colonic inflammatory conditions through regulation of the translocation of NF-kappaB (show NFKB1 Antibodies) into the nucleus

  9. Lymphocyte binding to MAdCAM-1 via alpha4beta7 integrin activates a signal transduction pathway involving tyrosine phosphorylation of paxillin (show PXN Antibodies) and p105(Cas-L (show NEDD9 Antibodies))

  10. Mucosal addressin cell adhesion molecule 1 plays an unexpected role in the development of mouse guard hair.

Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) Antigen Profile

Protein Summary

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.

Gene names and symbols associated with MADCAM1

  • mucosal vascular addressin cell adhesion molecule 1 (MADCAM1) antibody
  • mucosal vascular addressin cell adhesion molecule 1 (Madcam1) antibody
  • AV211525 antibody
  • MACAM1 antibody

Protein level used designations for MADCAM1

MAdCAM-1 , hMAdCAM-1 , mucosal addressin cell adhesion molecule 1 , mucosal addressin cell adhesion molecule-1 , mMAdCAM-1 , rMAdCAM-1 , mucosal addressin cellular adhesion molecule-1

GENE ID SPECIES
8174 Homo sapiens
17123 Mus musculus
54266 Rattus norvegicus
485103 Canis lupus familiaris
492312 Sus scrofa
527275 Bos taurus
100858236 Gallus gallus
654333 Ovis aries
100722478 Cavia porcellus
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