anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) Antibodies

Human Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) interaction partners

1. Both the ACT-1 assay and the MAdCAM-1 assay demonstrated acceptable reproducibility and repeatability. The assays were sufficiently stable to allow for clinical use. During clinical testing the assays demonstrated that vedolizumab was able to saturate peripheral cells at all doses tested.

2. Doxo-induced apoptosis has a role in inhibiting hepatocellular carcinoma by targeting Madcam1 and AKT and blocking protein translation initiation

3. MADCAM1 is up-regulated in liver cirrhosis with expression on peribiliary vascular plexus and lymphoid aggregates

4. Domain 1 of mucosal addressin cell adhesion molecule has an I1-set fold and a flexible integrin-binding loop.

5. Findings suggest that the inactive alpha4beta7 and alpha4beta7 activated by different stimuli have distinct conformations with different structural requirements for MAdCAM-1 binding.

6. Ca2+ is essential for cell tethering in flow and rolling interactions through alpha 4 integrins with MAdCAM-1 as substrate; Mg2+ promotes firm adhesion of cells on MAdCAM-1 but with much lower tethering efficiency in shear flow.

7. A crystal structure for the two extracellular amino-terminal domains of human MAdCAM-1

8. more extensive expression of MAdCAM-1 in Crohn's disease (CrD), than in ulcerative colitis, which could contribute not only to mucosal inflammation, but also to transmural inflammation in CrD.

9. MAdCAM-1/integrin alpha4beta7 homing system may participate in gastric inflammation in response to H pylori-infection and contributes to MALT formation, typically leading to the development of nodular gastritis.

10. a marker of graft rejection in small intestine transplantation

11. PI3-K/Akt is involved in the gut-specific differentiation of human intestinal microvascular endothelial cells, which results in expression of the mucosal addressin MAdCAM-1

12. Immobilized CCL25 and CCL28 are both able to trigger integrin alpha(4)beta(7)-dependent lymphocyte arrest on MAdCAM-1 under shear flow.

13. mucosal addressin cell adhesion molecule 1 may represent an important determinant for the generation of mucosal damage in celiac disease

14. MADCAM1 gene polymorphisms may be associated with the risk of chronic GVHD and may, also, affect mortality related to aHSCT.

Mouse (Murine) Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) interaction partners

1. Loss of MAdCAM-1 has beneficial effects regarding the development of NASH - manifested by reduced hepatic oxidative stress and decreased inflammation. In contrast, beta7-Integrin-deficiency results in increased steatohepatitis.

2. The results uncovered a previously unknown role of integrin a4b7-MAdCAM-1 interactions as drivers of colitis by directing inflammatory monocytes into the colon.

3. beta7 integrin, when expressed by hematopoietic stem cells (HSC), interacted with its endothelial ligand MAdCAM-1 in the Bone marrow microenvironment, thereby promoting HSC homing and engraftment.

4. Nkx2-3 deficiency reprograms the endothelial addressin preference for lymphocyte homing in Peyer's patches.

5. findings indicate that alpha4beta7*IgG can be used as a probe for functional MAdCAM-1 expressed on HEVs in GALT and could potentially serve as an anti-inflammatory drug inhibiting GALT-specific lymphocyte migration

6. ectopic expression of MAdCAM-1 at the BBB does not increase alpha4beta7-integrin-mediated immune cell trafficking into the CNS during MOG(aa35-55)-induced experimental autoimmune encephalomyelitis

7. Observed a significant decrease in expression of ICAM-1 and MAdCAM-1 mRNA/protein in lactobacillus plantarum treated colitis.

8. results suggest that AT1R regulates the expression of MAdCAM-1 under colonic inflammatory conditions through regulation of the translocation of NF-kappaB into the nucleus

9. Lymphocyte binding to MAdCAM-1 via alpha4beta7 integrin activates a signal transduction pathway involving tyrosine phosphorylation of paxillin and p105(Cas-L)

10. Mucosal addressin cell adhesion molecule 1 plays an unexpected role in the development of mouse guard hair.

11. spatial heterogeneity of MAdCAM-1 and VCAM-1 activation following TNF-alpha challenge may promote specific T lymphocyte recruitment in the inflamed colonic mucosa

12. Increased expression of mucosal addressin cell adhesion molecule-1 in gastritis induced by Helicobacter pylori

13. acute-graft vs host reaction was prevented when recruitment of donor T cells into Peyer's patches was interrupted by disrupting the gene encoding chemokine receptor CCR5 or by blocking integrin alpha(4)beta(7)-MAdCAM-1 interactions

14. expression of MAdCAM-1 by fibroblasts and melanomas suggests MAdCAM-1 may play a role in regulating host responses in the periphery, leucocyte transmigration across nonendothelial boundaries, or the homotypic interactions of some malignant melanomas

15. GST-3 is responsible for MECA-79 (MADCAM1)defined luminal ligands

16. alpha4beta7 and its counterreceptor MAdCAM-1 represent a novel adhesion pathway mediating hematopoietic progenitor homing to bone marrow following transplantation

17. MAdCAM-1 plays important roles in T-lymphocyte adherence in all intestinal sites.

18. In a chronic ileitis model, pathogenic CD4+ T cells use the MAdCAM-1/alpha4beta7 physiologic pathway in order to recirculate to the chronically inflamed small intestine.

19. In wild-type mice administered blocking monoclonal antibody (mAb) to VCAM1-1 but nor to Madcam1 recruitment of mast cells to the inflamed lung was not reduced.

20. These data indicate that TNF-alpha deficiency alters homoeostasis of the colonic chemokine/cytokine environment and humoral immune response, resulting in an exacerbation of acute DSS-induced colitis in TNF-alpha(-/-) mice.