anti-Musashi Homolog 2 (Drosophila) (MSI2) Antibodies

MSI2 encodes a protein containing two conserved tandem RNA recognition motifs. Additionally we are shipping MSI2 Proteins (6) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MSI2 124540 Q96DH6
MSI2 76626 Q920Q6
MSI2 360596  
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Top anti-MSI2 Antibodies at antibodies-online.com

Showing 10 out of 80 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-MSI2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Hela cell lysate 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-MSI2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human Small Intestine 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-MSI2 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:1562500  Positive Control:  HepG2 cell lysate 100 μL 2 to 3 Days
$249.00
Details
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
$429.84
Details
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
$429.84
Details
Human Mouse Un-conjugated IF, IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Mouse Un-conjugated IHC, ELISA, WB 100 μL 11 to 16 Days
$469.05
Details
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details

Top referenced anti-MSI2 Antibodies

  1. Human Monoclonal MSI2 Primary Antibody for IHC, ELISA - ABIN969295 : De Weer, Speleman, Cauwelier, Van Roy, Yigit, Verhasselt, De Moerloose, Benoit, Noens, Selleslag, Lippert, Struski, Bastard, De Paepe, Vandenberghe, Hagemeijer, Dastugue, Poppe: EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22. in Haematologica 2008 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal MSI2 Primary Antibody for WB - ABIN2776628 : Barbouti, Höglund, Johansson, Lassen, Nilsson, Hagemeijer, Mitelman, Fioretos: A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). in Cancer research 2003 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal MSI2 Primary Antibody for IHC, ELISA - ABIN966597 : Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ... in American journal of human genetics 2009 (PubMed)
    Show all 2 Pubmed References

More Antibodies against MSI2 Interaction Partners

Zebrafish Musashi Homolog 2 (Drosophila) (MSI2) interaction partners

  1. This line provides a valuable tool both for live imaging of the endogenous Msi2b at subcellular resolution and manipulation of Msi2b-expressing cells.

Human Musashi Homolog 2 (Drosophila) (MSI2) interaction partners

  1. Study determined that both USP10 and MSI2 proteins are upregulated in colon cancer cells. MSI2 expression and stability are regulated by USP10 via deubiquitination of Lys-48.

  2. HMGA2 knockdown regulates autophagy via MSI2-Beclin1 interactions to inhibit NF1 Malignant peripheral nerve sheath tumours (MPNSTs)growth, revealing potential therapeutic targets for these untreatable tumours.

  3. Knockdown of MSI2 induced downregulation of KRAS, and overexpression of MSI2 upregulated KRAS without causing an increase in the level of KRAS mRNA in bladder cancer. These results indicated that MSI2 post-transcriptionally regulated KRAS expression. Furthermore, MSI2 positively regulated KRAS expression through directly binding to the target sequence UAGUA in the 3'UTR region of KRAS mRNA.

  4. Here, the authors demonstrate that the canonical Musashi2 isoform is subject to regulated site-specific phosphorylation, converting Musashi2 from a repressor to an activator of target mRNA translation.

  5. We report novel associations between methylation at MSI2 and LARS2 and obesity-related traits. These results provide further insight into mechanisms underlying obesity-related traits, which can enable identification of new biomarkers in obesity-related chronic diseases.

  6. This study demonstrated that MSI2 is present in an oligomeric state in Alzheimer's disease brains compared to the age-matched non-demented subjects and that these large assemblies co-localize with tau contributing to the neurodegenerative pathogenesis.

  7. PLAG1 and USF2 cooperation is thus an important contributor to stem cell-specific expression of MSI2 and hematopoietic stem and progenitor cell-specific transcriptional circuitry.

  8. Results provide evidence that MSI2 variants may contribute to the age-at-onset in schizophrenia.

  9. Multiple MSI2-regulated mRNAs have been identified, and evidence has been provided that MSI2 controls IL6ST activity that control oncogenic signaling networks.

  10. Authors found that DANCR was distributed mostly in the cytoplasm and DANCR functioned as a miRNA sponge to positively regulate the expression of musashi RNA binding protein 2 (MSI2) through sponging miR-149 and subsequently promoted malignant phenotypes of bladder cancer cells, thus playing an oncogenic role in bladder cancer pathogenesis.

  11. This provides proof of concept for the development of Gn-lip as a molecular therapy for colon cancer with MSI1/MSI2 overexpression.

  12. MSI2 expression is increased in epithelial cells adjacent to breast carcinoma, and increases with increasing proximity.

  13. MSI2 expression was markedly increased in both PDAC cell lines and human PDAC specimens, and high MSI2 expression was associated with poor prognosis for PDAC. Forced MSI2 expression promoted PDAC proliferation, migration, and invasion in vitro and growth and metastasis in vivo, whereas knockdown of MSI2 expression did the opposite. Dysregulated KLF4/MSI2 signaling promotes PDAC progression and metastasis.

  14. MSI1 and MSI2 bind and regulate the mRNA stability and translation of proteins operating in essential oncogenic signaling pathways..This review provides a current overview of Musashi as a cancer driver and novel therapeutic target.

  15. High MSI2 expression is associated with esophageal squamous cell carcinoma.

  16. High Musashi2 expression is associated with pancreatic cancer.

  17. MSI2 regulates myeloid leukemia stem cells gene expression.

  18. these findings provide evidence that DBC2 suppresses tumorigenesis in breast cancer by ubiquitinating MSI2.

  19. Differential methylation of the MSI2 gene (chr17:55484635) in blood and islet cells is strongly related to hyperglycemia.

  20. our findings identified a novel regulatory mechanism of MSI2 as an upstream regulator of ESR1 and revealed the clinical relevance of the RNA-binding protein MSI2 in breast cancer.

Mouse (Murine) Musashi Homolog 2 (Drosophila) (MSI2) interaction partners

  1. the testis-expressed transcription factor, Tbx1, and the piRNA regulator of gamete development, Piwil1, were both found to be targeted for translational repression by MSI2.

  2. Absence of Musashi2 in osteoclast precursors promotes apoptosis and inhibits RANKL-induced NF-kappaB activation, which is essential for osteoclast survival.

  3. Msi2 primarily recognizes mRNA 3'UTRs at sites enriched in multiple copies of UAG motifs in epithelial progenitor cells.

  4. Msi proteins are dispensable for normal homeostasis and self-renewal of the active intestinal stem cell.

  5. our findings reveal the importance of Msi2 in suppressing hair regeneration and maintaining hair follicle stem cells quiescence

  6. studies highlight Msi reporters as a unique tool to identify therapy resistance, and define Msi signalling as a central regulator of pancreatic cancer

  7. MSI1 and MSI2 display distinct expression profiles during mammalian folliculogenesis and that MSI2 is required for pre-antral follicle development

  8. Through expression studies and utilizing a transgenic Msi1 testis-specific overexpression model, we have identified 2 unique RNA-binding targets of MSI1 in spermatogonia, Msi2 and Erh, and have demonstrated a role for MSI1 in translational regulation.

  9. Msi proteins contribute to an epithelial gene expression program in neural and mammary cell types.

  10. Msi2 is an important regulator of the hematopoietic stem cell (HSC) translatome and balances HSC homeostasis and lineage bias.

  11. Ectopic expression of Musashi 2 isoform 1, but not isoform 2, enhanced the cloning efficiency of embryonic stem cells, but both isoforms were required for the self-renewal of embryonic stem cells.

  12. Our data indicate that Msi2 maintains the stem cell compartment mainly by regulating the proliferation of primitive progenitors downstream of long term hematopoietic stem cells

  13. Pard6a, Prkcz, and Msi2 shRNA-mediated depletion significantly impaired hematopoietic stem cell repopulation.

  14. data show that the Musashi-Numb pathway can control the differentiation of chronic myeloid leukemia cells

  15. Expression levels in human myeloid leukemia directly correlate with decreased survival in patients, defining MSI2 as a new prognostic marker and new target for therapy.

  16. data suggest that msi1 and msi2 are cooperatively involved in the proliferation and maintenance of CNS stem cell populations

  17. the complementary expression patterns of the murine Msi paralogues Msi1 and Msi2 during spermatogenesis support the idea of distinct, evolutionarily conserved roles of Msi

MSI2 Antigen Profile

Protein Summary

This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with MSI2

  • musashi RNA binding protein 2 (MSI2) antibody
  • musashi RNA binding protein 2 (msi2) antibody
  • musashi RNA-binding protein 2b (msi2b) antibody
  • musashi RNA binding protein 2 S homeolog (msi2.S) antibody
  • musashi RNA-binding protein 2 (Msi2) antibody
  • 1700105C15Rik antibody
  • AI451722 antibody
  • AI563628 antibody
  • AW489193 antibody
  • msi2 antibody
  • MSI2H antibody
  • musashi-2 antibody
  • musashi2 antibody
  • RGD1560397 antibody
  • xrp1 antibody
  • zgc:63812 antibody
  • zgc:174035 antibody

Protein level used designations for MSI2

musashi homolog 2 (Drosophila) , musashi homolog 2 , musashi 2 , RNA-binding protein Musashi homolog 2 , musashi-2 , Musashi2 , Musashi homolog 2

GENE ID SPECIES
417667 Gallus gallus
748578 Pan troglodytes
100038158 Xenopus (Silurana) tropicalis
475148 Canis lupus familiaris
505542 Bos taurus
394084 Danio rerio
399260 Xenopus laevis
124540 Homo sapiens
76626 Mus musculus
360596 Rattus norvegicus
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