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Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060) (Adams et al., 1998 [PubMed 9724633]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Muskelin 1, Intracellular Mediator Containing Kelch Motifs Antibodies (51) and many more products for this protein.
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A meta-analysis genome wide association study suggest MKLN1 is associated with early-onset bipolar disorder.
RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and p44CTLH form complexes in cells
These novel findings identify a role for muskelin-RanBP9 complex in pathways that integrate cell morphology regulation and nucleocytoplasmic communication.
The first crystal structure of mouse muskelin discoidin domain (MK-DD) is reported at 1.55 A resolution, which reveals a distorted eight-stranded beta-barrel with two short alpha-helices at one end of the barrel.
This novel interaction between TBX20b and MKLN1 may help elucidate new regulatory mechanisms within heart development.
Muskelin regulates retrograde actin filament and microtubule-dependent GABA-A receptor trafficking.
expression of muskelin during embryonic development in muscle tissues, multiple epithelia & brain; findings show PKC activation or inhibition regulates the profile of endogenous muskelin isoelectric variants; muskelin is a substrate for PKCalpha (show PKCa Proteins) in vitro
Muskelin represents a multifunctional protein associated with membranes and/or large protein complexes in most neurons of the central nervous system.
Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060) (Adams et al., 1998
, muskelin 1, intracellular mediator containing kelch motifs