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Myosin Heavy Chain 7, Cardiac Muscle, beta Proteins (MYH7)

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. Additionally we are shipping Myosin Heavy Chain 7, Cardiac Muscle, beta Antibodies (53) and Myosin Heavy Chain 7, Cardiac Muscle, beta Kits (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MYH7 4625 P12883
Rat MYH7 MYH7 29557 P02564
Mouse MYH7 MYH7 140781 Q91Z83
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Top Myosin Heavy Chain 7, Cardiac Muscle, beta Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$704.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Primates His tag   1 mg Log in to see 60 to 71 Days
$2,623.50
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$639.61
Details

MYH7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) Interaction Partners

Human Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) interaction partners

  1. Five of the 19 patients (26.3%) had either a pathogenic variant or a likely pathogenic variant in MYBPC3 (show MYBPC3 Proteins) (n=1), MYH7 (n=1), RYR2 (n=2), or TNNT2 (show TNNT2 Proteins) (n=1). All five variants were missense variants that have been reported previously in patients with channelopathies or cardiomyopathies

  2. Double MYH7 CTTNA3 heterozygotes showed a variable clinical expression of arrhythmogenic cardiomyopathy and hypertrophic cardiomyopathy. One carrier of double mutations in CTTNA3 and MYH7 genes did not fulfill the current diagnostic criteria for cardiomyopathy.

  3. Data provide evidence that MYH7 mutations contributed to 24.4% MYBPC3 (show MYBPC3 Proteins) mutations of hypertrophic cardiomyopathy (HCM) cases, that MYBPC3 (show MYBPC3 Proteins) constitute the preeminent cause of HCM and that both mutations are phenotypically indistinguishable.

  4. Digenic inheritance of two novel variants in TNNT2 (show TNNT2 Proteins) and MYH7 is associated with a severe form of dilated cardiomyopathy.

  5. MYH7-V878A is a hot spot among ethnic Han Chinese with a high penetrance.

  6. Unlike previous Hypertrophic cardiomyopathy (HCM)mutations studied at the molecular level using human beta-cardiac myosin, early-onset HCM mutations lead to significantly larger changes in the fundamental biomechanical parameters and show clear hyper-contractility

  7. We investigated a male with familial familial hypertrophic cardiomyopathy with restrictive physiology and we identified a novel missense mutation p.Arg719Leu of beta-myosin heavy chain (MYH7) gene

  8. ur results suggest that the basis for the pathogenic effect of the R1845W and H1901L mutations of the MYH7 are primarily structural rather than functional. Further analyses are needed to identify the primary trigger for the histological changes seen in muscle biopsies of patients with L1793P and E1883K mutations.

  9. The authors demonstrate myosin tail (S2)-dependent functional regulation of actin-activated human beta-cardiac myosin ATPase. In addition, they show that both S2 and MyBP-C (show MYBPC3 Proteins) bind to S1 and that phosphorylation of either S1 or MyBP-C (show MYBPC3 Proteins) weakens these interactions.

  10. Our study supports that mutations in MYH7 and MYBPC3 (show MYBPC3 Proteins) should be the first focus of moleculargenetic analysis in HCM, and that mutations in TNNT2 (show TNNT2 Proteins) have a low prevalence in Brazilian population. All mutations detected were missense mutations, whereas two mutations in MYH7 had not been described before.

Cow (Bovine) Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) interaction partners

  1. Tm affects the conformation of actin so as to increase the area of hydrophobic interaction between actin and myosin molecules

Pig (Porcine) Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) interaction partners

  1. Myosin regulatory light chain phosphorylation enhances cardiac beta-myosin in vitro motility under load.

  2. Mutation analysis of MYH7 gene revealed an in-frame insertion within exon 30 of MYH7 which was perfectly associated with the disease phenotype and confirmed the dominant inheritance.

Mouse (Murine) Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) interaction partners

  1. These data demonstrate functional cooperation between Sox6 and Nfix in regulating MyHC-I expression during prenatal muscle development.[MyHC-1]

  2. Male/female Myh7 mutant mice display sex dimorphic crossbridge kinetics accompanied by sex- and hypertrophic cardiomyopathy-dependent cardiac remodeling at the morphometric, histological, and cellular level.

  3. The promoter regions of the SERCA (show ATP2A3 Proteins)-2A and beta-MHC genes, Atp2a2 (show ATP2A2 Proteins) and Myh7, respectively in murine hearts after one or eight weeks of pressure overload induced by transverse aortic constriction, were evaluated.

  4. Foxo1 (show FOXO1 Proteins) has important roles in promoting diabetic cardiomyopathy and controls beta-MHC expression in the development of cardiac dysfunction.

  5. Cooperative/allosteric effects on actomyosin crossbridge recruitment dynamics are increased by beta-MHC.

  6. Reexpression of bMHC is associated at the bMHC promoter with increased H3ac but not H3K4me3.

  7. Metabolic and myosin isoform gene expression switch in sepsis-induced myocardial depression is inducible nitric oxide synthase (show NOS2 Proteins)-dependent.

  8. residues situated within or close to the actin-binding interface of the myosin head influence actin binding and thereby modulate actin-activated ATPase activity

  9. Simultaneous defects in MHC7 & TnI (show TNNI2 Proteins) accelerate onset & progression of familial hypertrophic cardiomyopathy. Compared with single-mutant models, double-mutant mice develop severe disease & premature death, progressing directly to a dilated phenotype.

  10. the functional consequences of the mutation are fundamentally changed depending upon the context of the cardiac MHC isoform.

Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) Protein Profile

Protein Summary

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.

Gene names and symbols associated with MYH7

  • myosin heavy chain 7 (MYH7)
  • myosin heavy chain 7 (Myh7)
  • myosin, heavy chain 7, cardiac muscle, beta (MYH7)
  • myosin, heavy polypeptide 7, cardiac muscle, beta (Myh7)
  • AMHC1 protein
  • B-MHC protein
  • beta-MHC protein
  • CMD1S protein
  • CMH1 protein
  • MPD1 protein
  • Myhc-b protein
  • MyHC-I protein
  • Myhcb protein
  • myosin protein
  • myosin-7 protein
  • SPMD protein
  • SPMM protein

Protein level used designations for MYH7

beta-myosin heavy chain , myHC-beta , myhc-slow , myopathy, distal 1 , myosin heavy chain (AA 1-96) , myosin heavy chain 7 , myosin heavy chain slow isoform , myosin heavy chain, cardiac muscle beta isoform , myosin, heavy polypeptide 7, cardiac muscle, beta , myosin-7 , rhabdomyosarcoma antigen MU-RMS-40.7A , beta myosin heavy chain , myHC-slow , myosin heavy chain polypeptide 7 cardiac muscle fetal , myosin heavy chain, cardiac muscle, fetal , myosin heavy chain, polypeptide 7 , type slow/beta myosin heavy chain , cardiac muscle , chick atrial myosin heavy chain , heavy polypeptide 7 , myosin heavy chain , MYH-beta/slow , cardiac myosin heavy chain beta , beta cardiac myosin heavy chain , myosin 7 , myosin heavy chain slow type 1 (beta cardiac) , beta-myosin-heavy-chain , myosin beta heavy chain

GENE ID SPECIES
4625 Homo sapiens
29557 Rattus norvegicus
282714 Bos taurus
395350 Gallus gallus
396860 Sus scrofa
140781 Mus musculus
791234 Equus caballus
403807 Canis lupus familiaris
100101566 Oryctolagus cuniculus
100727138 Cavia porcellus
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