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MYO9B encodes a member of the myosin family of actin-based molecular motor heavy chain proteins.
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Human Polyclonal MYO9B Primary Antibody for ELISA, WB - ABIN251552
McMichael, Scherer, Franklin, Lee: The RhoGAP activity of myosin IXB is critical for osteoclast podosome patterning, motility, and resorptive capacity. in PLoS ONE 2014
Show all 2 Pubmed References
Analysis of PTPN22 (show PTPN22 Antibodies), ZFAT (show ZFAT Antibodies) and MYO9B polymorphisms in Turner Syndrome and risk of autoimmune disease.
Mutating either of the two arginine fingers impaired the catalytic activity of Myo9b-RhoGAP (show ARHGAP1 Antibodies).
meta-analysis indicates that MYO9B gene polymorphisms might be not associated with coeliac disease susceptibility in Caucasians. [meta-analysis]
this meta-analysis shows that MYO9B genetic polymorphism is associated with Crohn's disease and ulcerative colitis
newly defined SLIT/ROBO/Myo9b/RhoA (show RHOA Antibodies) signaling pathway that restricts lung cancer progression and metastasis.
Our data suggest a link between MYO9B variants to an increased intestinal permeability in Crohn's disease patients.
Results does not support the association of MYO9B with schizophrenia in Chinese population.
MYO9B SNPs may influence the sub-phenotypic expression of Crohn's disease but did not find an association between these MYO9B polymorphisms and intestinal permeability in IBD.
Variants in MYO9B may be involved in acute pancreatitis
genetic variation MYO9B gene is associated with celiac disease as a protective or a risk factor
Myo9b regulates a subset of RhoA (show RHOA Antibodies)-activated processes necessary for IGF-1 (show IGF1 Antibodies) responsiveness in osteogenic cells.
This study shows that Myo9b in hematopoietic cells impacts on the induction and progression of EAE. Specifically, Myo9b regulates the onset of EAE symptoms, which correlates with immune cell proliferation and infiltration into the CNS.
we have identified Myo9b as a key regulator of spatiotemporal Rho activity in DCs with cofilin (show CFL1 Antibodies) as a target protein of major importance for the regulation of DC migration and T cell stimulatory capacity.
Data identify the "motorized Rho inhibitor" Myo9b as a key molecular component required for spatially coordinated cell shape changes and motility.
Myo9b functions as a motorized molecule in regions of actin polymerization and Myo9b head sequences are important for in vivo motor properties.
Data show that myo9b is localized in actin-rich ellipsoids of fish cones.
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin\; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.
, unconventional myosin IXb
, unconventional myosin-9b
, unconventional myosin-IXb
, Unconventional myosin from rat 3
, myr 5
, myosin IXB