Myotilin Proteins (MYOT)

MYOT encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. Additionally we are shipping Myotilin Antibodies (75) and Myotilin Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MYOT 9499 Q9UBF9
MYOT 58916 Q9JIF9
Rat MYOT MYOT 291605  
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Top Myotilin Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg 11 Days
Wheat germ Human GST tag 2 μg 11 to 12 Days

MYOT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for Myotilin (MYOT) Interaction Partners

Human Myotilin (MYOT) interaction partners

  1. sequence conservation analysis of myotilin shed light on the molecular basis of myotilinopathies and revealed several motifs in Ig domains found also in I-band proteins.

  2. A French family affected with a late onset proximal and distal muscle weakness and myofibrillar myopathy on muscle pathology, in which the siblings known to be clinically affected were homozygous for the c.179C>T (p.Ser60Phe) myotilin gene mutation is reported.

  3. Describe the first homozygous mutation in the myotilin gene leading to a novel, autosomal recessive subtype of myofibrillar myopathy (MFM).

  4. Analysis of myotilin turnover provides mechanistic insight into the role of myotilinopathy-causing mutations

  5. A second known pedigree with LGMD1A: this finding constitutes a gold standard of proof that mutations in the myotilin gene cause Limb-Girdle Muscular Dystrophy 1A

  6. Myotilin a thin filament-associated Z-disc protein.It binds to alpha-actinin and filamin c and is mutated in limb girdle muscular dystrophy 1A (LGMD1A).myotilin binds F-actin and prevents filament disassembly induced by Latrunculin A

  7. Mutations in myotilin cause MFM; exon 2 of MYOT is a hotspot for mutations; peripheral neuropathy, cardiomyopathy, and distal weakness greater than proximal weakness are part of the spectrum of myotilinopathy; not all cases have a limb-girdle phenotype

  8. Our findings provide evidence for a novel connection between the Z-disc protein myotilin and the sarcolemma via filamins and beta1 integrins.

  9. The function of the myotilin protein is studied with regards its actin-organizing properties.

  10. A novel mutation in the myotilin gene results in the clinical and pathologic phenotype termed "spheroid body myopathy." Mutations in this gene also cause limb-girdle muscular dystrophy 1A and are associated with myofibrillar myopathy.

  11. Mutations within the MYOT gene are not a cause for Vocal Cord and Pharyngeal Weakness with Distal Myopathy (VCPDM).

  12. multigenerational French family in which gene sequencing identified a S60F myotilin mutation in all patients with full penetrance despite very late onset

  13. Myotilin mutations promote aggregate-dependent contractile dysfunction similar to Limb-girdle Muscular Dystrophy type 1A and Myofibrillar Myopathy.

  14. Myotilin S55F mutations may cause a clinically distinct autosomal-dominant late-onset and lower-limb distal myopathic syndrome. MRI helps to depict the topography of fatty muscle atrophy and to detect gene mutation carriers.

  15. new autosomal dominant kindred with generalized symmetrical increase in muscle bulk

  16. This is the first report of a binding motif common to both the myotilin and the FATZ (calsarcin/myozenin) families that is specific for interactions with Enigma family members.

  17. Data show that in myofibrillar myopathies myotilin exhibites significant alterations in their localization.

  18. study presents high-resolution structure of the first Ig-domain of myotilin determined with solution state NMR spectroscopy; structure of MyoIg1 exhibits I-type Ig-fold

  19. identified a novel MYOT mutation in Exon 9 encoding the second immunoglobulin-like domain in 1 patient with clinically typical limb girdle muscular dystrophy

Mouse (Murine) Myotilin (MYOT) interaction partners

  1. Myotilin does not have a significant influence on muscle mass, muscle fiber size, or regulation of muscle contraction. Alternatively, compensatory over-expressions of other elements may compensate for the lack of myotilin.

  2. features suggest an important role for myotilin in sarcomere organization.

  3. either myotilin does not participate in muscle development and basal function maintenance or other proteins serve as structural and functional compensatory molecules when myotilin is absent

  4. In single-transgenic mutant mice, double-transgenic mice overexpressing myotilin showed more severe muscle degeneration, enhanced myofibrillar aggregation, and earlier onset of aggregation.

Pig (Porcine) Myotilin (MYOT) interaction partners

  1. Genetic association studies show that different TTID genotypes were significantly associated with carcass traits, including skin percentage, loin eye area and average skin thickness.

  2. Sequence analysis and polymorphism identification in the TTID gene associated with meat quyality traits in Sus scrofa.

Myotilin (MYOT) Protein Profile

Protein Summary

This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene names and symbols associated with Myotilin Proteins (MYOT)

  • myotilin (MYOT)
  • myotilin (Myot)
  • myotilin (myot)
  • 5530402I04Rik protein
  • LGMD1 protein
  • LGMD1A protein
  • MFM3 protein
  • MYOT protein
  • ttid protein
  • TTOD protein

Protein level used designations for Myotilin Proteins (MYOT)

57 kDa cytoskeletal protein , myofibrillar titin-like Ig domains protein , titin immunoglobulin domain protein (myotilin) , titan-like protein , titin immunoglobulin domain protein , myotilin , LOW QUALITY PROTEIN: myotilin

9499 Homo sapiens
58916 Mus musculus
462087 Pan troglodytes
507884 Bos taurus
100024740 Monodelphis domestica
100101550 Sus scrofa
100226120 Taeniopygia guttata
100344050 Oryctolagus cuniculus
100400348 Callithrix jacchus
100447797 Pongo abelii
100583498 Nomascus leucogenys
291605 Rattus norvegicus
416299 Gallus gallus
549913 Xenopus (Silurana) tropicalis
100855693 Canis lupus familiaris
100072634 Equus caballus
100718324 Cavia porcellus
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