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NANS encodes an enzyme that functions in the biosynthetic pathways of sialic acids. Additionally we are shipping NANS Antibodies (63) and NANS Kits (5) and many more products for this protein.
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Human NANS Protein expressed in HEK-293 Cells - ABIN2726801
van Karnebeek, Bonafé, Wen, Tarailo-Graovac, Balzano, Royer-Bertrand, Ashikov, Garavelli, Mammi, Turolla, Breen, Donnai, Cormier, Heron, Nishimura, Uchikawa, Campos-Xavier, Rossi, Hennet et al.: NANS-mediated synthesis of sialic acid is required for brain and skeletal development. ... in Nature genetics 2016
NANS deficiency is associated with defect in brain and skeletal development.
The structure of the C-terminal antifreeze-like domain of human sialic acid synthase was determined. The structure comprises one alpha- and two single-turn 3(10)-helices and two beta-strands, and is similar to those of the type III antifreeze proteins.
This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively\; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.
N-acetylneuraminic acid synthase
, N-acetylneuraminic acid phosphate synthase
, N-acetylneuraminic acid synthase (sialic acid synthase)
, sialic acid synthase
, N-acetylneuraminate synthase
, N-acetylneuraminate-9-phosphate synthase
, sialic acid phosphate synthase