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NANS encodes an enzyme that functions in the biosynthetic pathways of sialic acids. Additionally we are shipping NANS Antibodies (65) and NANS Kits (5) and many more products for this protein.
Showing 8 out of 10 products:
Human NANS Protein expressed in HEK-293 Cells - ABIN2726801
van Karnebeek, Bonafé, Wen, Tarailo-Graovac, Balzano, Royer-Bertrand, Ashikov, Garavelli, Mammi, Turolla, Breen, Donnai, Cormier, Heron, Nishimura, Uchikawa, Campos-Xavier, Rossi, Hennet et al.: NANS-mediated synthesis of sialic acid is required for brain and skeletal development. ... in Nature genetics 2016
This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively\; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.
N-acetylneuraminic acid synthase
, N-acetylneuraminic acid phosphate synthase
, N-acetylneuraminic acid synthase (sialic acid synthase)
, sialic acid synthase
, N-acetylneuraminate synthase
, N-acetylneuraminate-9-phosphate synthase
, sialic acid phosphate synthase