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NAT6 encodes a member of the N-acetyltransferase family. Additionally we are shipping NAT6 Proteins (9) and many more products for this protein.
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Characterization of the murine hyaluronidase (show HAase Antibodies) gene region reveals complex organization and cotranscription of Hyal1 (show HYAL1 Antibodies) with downstream genes, Fus2 and Hyal3 (show HYAL3 Antibodies).
NAT6/FUS-2 is the N-alpha acetyltransferase 80 (NAA80/NatH (show NAA15 Antibodies)) acting post-translationally and specifically on processed animal actins. This NAA80 mediated actin N-terminal acetylation is crucial for actin polymerization and depolymerization, and regulates the actin cytoskeleton and cell motility.
NAA80/NatH is dedicated to the post-translational N-terminal acetylation of processed actins. The structure of NAA80 reveals features like a positively charged catalytic groove perfectly suited to bind the acidic actin N-terminus. A cellular factor restricting NAA80 to processed actins is NatB, which co-translationally acetylates all cellular Met-starting N-termini with acidic amino acids at the second position.
Characterization of the murine hyaluronidase (show HAase Antibodies) gene region reveals complex organization and cotranscription of Hyal1 (show HYAL1 Antibodies) with downstream genes, Fus2 and Hyal3 (show SPAM1 Antibodies).
newly identified polymorphism leads to a non-conservative amino acid change (R222W) located between the acetyltransferase and the proline-rich domains; analysis suggests no likely association between nasopharyngeal cancer and the FUS2 gene polymorphism
This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon.
, protein fus-2
, protein fusion-2
, N-acetyltransferase 6