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NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. Additionally we are shipping NMI Proteins (9) and NMI Kits (7) and many more products for this protein.
Showing 10 out of 58 products:
Human Monoclonal NMI Primary Antibody for IHC (p), ELISA - ABIN522559
Saito, Yukawa, Matozaki, Mikami, Yamagami, Yamagishi, Kuga, Hatayama, Nakayama: Nmi interacts with Hsp105? and enhances the Hsp105?-mediated Hsp70 expression. in Experimental cell research 2014
These results revealed that IRF-1 (show IRF1 Antibodies) is involved in the IFN-inducible expression of Nmi (show MYO1C Antibodies).
Our study showed that NMI (show MYO1C Antibodies) suppressed tumor growth by inhibiting PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies), MMP2 (show MMP2 Antibodies)/MMP9 (show MMP9 Antibodies), COX-2 (show COX2 Antibodies)/PGE2 signaling pathways and p300 (show EP300 Antibodies)-mediated NF-kappaB (show NFKB1 Antibodies) acetylation, and predicted a favorable prognosis in human lung adenocarcinomas, suggesting that NMI (show MYO1C Antibodies) was a potential tumor suppressor in lung cancer.
results provide new insights into understanding the regulatory mechanism of cancer stem cells and suggest that the NMI (show MYO1C Antibodies)-YY1 (show YY1 Antibodies)-hTERT signaling axis may be a potential therapeutic target for breast cancers.
Damage-associated molecular patterns (DAMP (show AMPH Antibodies)) are important mediators of innate immunity. Here the authors show that N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35 (show IFI35 Antibodies)) act as DAMPs to promote inflammation by activating macrophages via the Toll-like receptor 4 (show TLR4 Antibodies) and NF-kappaB (show NFKB1 Antibodies) pathways.
These investigations demonstrated etoposide-induced NMI (show MYO1C Antibodies) can suppress tumor proliferation and promote cell apoptosis by activating the ARF-p53 (show TP53 Antibodies) signaling pathway in lung carcinoma. Our results provide an alternative mechanism for etoposide in lung carcinoma and suggest NMI (show MYO1C Antibodies) has a critical role in suppressing lung carcinoma progression.
Data suggest that N-myc (and STAT) interactor (NMI) could improve its downstream target bradykinin B2 receptor (BDKRB2) expression to induce extracellular signal-regulated kinases (ERK) 1 (show MAPK3 Antibodies)/2 activation, and thereby further evoke malignant progression of hepatocellular carcinoma (HCC (show FAM126A Antibodies)).
N-Myc (show MYCN Antibodies)-interacting protein (NMI (show MYO1C Antibodies)) negatively regulates epithelial-mesenchymal transition by inhibiting the acetylation of NF-kappaB (show NFKB1 Antibodies)/p65 (show GORASP1 Antibodies) in histone deacetylase (show HDAC1 Antibodies)-dependent manner.
N-myc and STAT interactor sensitizes breast cancer cells to cisplatin treatment through DRAM1 (show DRAM1 Antibodies) dependent autophagy.
Results show that aberrant miR (show MLXIP Antibodies)-29 expression may account for reduced NMI (show MYO1C Antibodies) expression in breast tumors and mesenchymal phenotype of cancer cells that promotes invasive growth.
The results showed that SARS (show SARS Antibodies) coronavirus protein 6 can promote the ubiquitin-dependent proteosomal degradation of Nmi (show MYO1C Antibodies).
These findings suggest that Nmi is a negative regulator of the virus-triggered induction of type I IFNs that targets IRF7 (show IRF7 Antibodies)
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.
, N-mcy (and STAT) interactor
, N-myc (and STAT) interactor
, N-myc and STAT interactor
, N-myc/STAT interactor