NAD(P)H Dehydrogenase, Quinone 1 Proteins (NQO1)

NQO1 is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. Additionally we are shipping NQO1 Antibodies (223) and NQO1 Kits (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NQO1 1728 P15559
NQO1 24314 P05982
NQO1 18104 Q64669
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Top NQO1 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 2 to 3 Days
$775.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$860.20
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,713.33
Details
Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
$5,769.50
Details
Escherichia coli (E. coli) Human S tag,His tag 100 μg Log in to see 15 to 18 Days
$720.00
Details
Escherichia coli (E. coli) Rat T7 tag,His tag 100 μg Log in to see 15 to 18 Days
$749.00
Details
Escherichia coli (E. coli) Mouse S tag,His tag 100 μg Log in to see 15 to 18 Days
$768.00
Details

NQO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Rat (Rattus) ,
,
Mouse (Murine)
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More Proteins for NAD(P)H Dehydrogenase, Quinone 1 (NQO1) Interaction Partners

Zebrafish NAD(P)H Dehydrogenase, Quinone 1 (NQO1) interaction partners

  1. Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt (show AKT1 Proteins) and JNK (show MAPK8 Proteins)/Nrf2 (show NFE2L2 Proteins)/NQO1 pathway.

Human NAD(P)H Dehydrogenase, Quinone 1 (NQO1) interaction partners

  1. These results indicate that dual-negative expression of Nrf2 (show GABPA Proteins) and NQO1 is predictive of a better prognosis in NSCLC patients.

  2. Case-control study found a significant difference was observed between large artery atherosclerotic ischemic stroke patients and controls with respect to the CYP2E1 (show CYP2E1 Proteins)*5B genotype and allele distribution. NQO1*2 polymorphism genotype distribution was significantly different between patients and controls and heterozygote *1*2 genotype was found to be a protective factor against large artery atherosclerotic ischemic stroke.

  3. the NQO1 Pro187Ser or SULT1A1 (show SULT1A1 Proteins) Arg213His polymorphism combination with smoking significantly confer susceptibility to BC. [META-ANALYSIS]

  4. Docosahexaenoic acid (DHA) activates Nrf2 (show GABPA Proteins), possibly through modification of critical Keap1 (show KEAP1 Proteins) cysteine 288 residue and PKCdelta (show PKCd Proteins)-mediated phosphorylation of Nrf2 (show GABPA Proteins), leading to upregulation of HO-1 (show HMOX1 Proteins) and NQO1 expression.

  5. the upregulation of Cav1 (show CAV1 Proteins) contributed to the DHA-mediated p53 (show TP53 Proteins) activation and the downregulation of the redox enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1), which have been reported to contribute to the activation of the cell death pathway.

  6. NQO1 may act as a redox-dependent switch where the protein responds to the NAD(P)+/NAD(P)H redox environment by altering its structure promoting the binding or dissociation of NQO1 with target macromolecules

  7. Taken together, we proposed that NQO1 could potentiate NSCLC cell proliferation by enhancing cellular glycometabolism, and HKII (show HK2 Proteins) is a key mediator of this mechanism.

  8. The higher incidence of NQO1 mutants among bronchopulmonary dysplasia (BPD) neonates as well as the presence of the mutant allele in all neonates with <= 1,000 g who developed BPD provided the first evidence for a possible pathogenetic role of the C(609)T polymorphism in BPD susceptibility due to the reduction or loss of NQO1 enzymatic activity.

  9. Activity of the enzyme NQO1 does not appear to be developmentally regulated, with levels of hepatic activity as high in neonates and children as they are in adults. Obesity may increase hepatic NQO1 activity in children.

  10. Novel RNA-binding activity of NQO1 promotes SERPINA1 (show SERPINA1 Proteins) mRNA translation.

Mouse (Murine) NAD(P)H Dehydrogenase, Quinone 1 (NQO1) interaction partners

  1. Novel RNA-binding activity of NQO1 promotes SERPINA1 (show SERPINA1 Proteins) mRNA translation.

  2. NQO1 and autophagy participate in a protective role in cisplatin injury.

  3. A significant increase was found in Nrf2 (show NFE2L2 Proteins)-ARE activity after partial hepatectomy (PHx). The signal maximum was recorded on the third day after PHx. Significantly more hepatocytes were positive for Nrf2 (show NFE2L2 Proteins) and HO-1 (show HMOX1 Proteins) on the third postoperative day compared with baseline levels. The mRNA expression of HO-1 (show HMOX1 Proteins) and NQO1 were significantly increased on day 3.

  4. Miroestrol restored hepatic NQO1 expression in beta-naphthoflavone-treated mice.

  5. previous and present results collectively show that NQO1 is involved in the formation of tight junctions in the small intestine, and that defects in NQO1 enhance C. difficile toxin A-induced acute inflammatory responses, presumably via the loss of epithelial cell tight junctions

  6. NQO1 plays a critical role in protection against energy depletion in acetaminophen-induced liver injury, and is associated with improvement of mitochondrial dysfunction

  7. The present results demonstrate that exacerbated cisplatin-induced nephrotoxicity under the NQO1-knockout condition was accompanied by the reduced expression of MRN complex proteins, ATM (show ATM Proteins), PARP1 (show PARP1 Proteins), and Sirt1 (show SIRT1 Proteins).

  8. Taken together, these data suggest that EEEC attenuates oxidative stress by activating Nrf2 (show NFE2L2 Proteins)-mediated HO-1 (show HMOX1 Proteins) and inducing NQO-1 via the activation of MAPK (show MAPK1 Proteins) signaling pathways.

  9. We defined the basal and butylated hydroxyanisole induced expression patterns of Nqo1, AKR1B8, and Ho-1 (show HMOX1 Proteins) in the liver and small intestine of C57BL/6 mice.

  10. The colons of NQO1-KO mice also showed high levels of reactive oxygen species (ROS (show ROS1 Proteins)) and histone deacetylase (HDAC (show HDAC1 Proteins)) activity, which are known to affect transcriptional regulation.

Pig (Porcine) NAD(P)H Dehydrogenase, Quinone 1 (NQO1) interaction partners

  1. The obtained data convincingly showed that porcine NADPH-d cells may produce nitric oxide.

  2. Immunoreactivity of eNOS (show NOS3 Proteins) was similar to NADPH-d staining. Clear iNOS (show NOS2 Proteins) immunoreactivity was detected in the luminal epithelium, endometrial stroma and individual endometrial glands.

Cow (Bovine) NAD(P)H Dehydrogenase, Quinone 1 (NQO1) interaction partners

  1. NQO1 expression was increased in the ruminal papillae of more efficient low residual feed intake (RFI (show RNF34 Proteins)) animals compared to the high RFI (show RNF34 Proteins) animals

NQO1 Protein Profile

Protein Summary

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with NQO1

  • NAD(P)H dehydrogenase, quinone 1 (nqo1)
  • NAD(P)H quinone dehydrogenase 1 (NQO1)
  • NAD(P)H dehydrogenase, quinone 1 (Bpet2092)
  • NAD(P)H dehydrogenase, quinone 1 L homeolog (nqo1.L)
  • NAD(P)H quinone dehydrogenase 1 (nqo1)
  • NAD(P)H quinone dehydrogenase 1 (Nqo1)
  • NAD(P)H dehydrogenase, quinone 1 (Nqo1)
  • AV001255 protein
  • DHQU protein
  • Dia4 protein
  • Dtd protein
  • NADPH-d protein
  • Nmo-1 protein
  • Nmo1 protein
  • Nmor1 protein
  • NMORI protein
  • nqo1 protein
  • Ox-1 protein
  • Ox1 protein
  • Qr1 protein
  • wu:fb63c10 protein
  • zgc:77191 protein

Protein level used designations for NQO1

NAD(P)H dehydrogenase [quinone] 1 , NAD(P)H menadione oxidoreductase 1, dioxin-inducible , NAD(P)H dehydrogenase, quinone 1 , DT-diaphorase , DTD , NAD(P)H:quinone oxidoreductase 1 , QR1 , azoreductase , menadione reductase , phylloquinone reductase , quinone reductase 1 , nad(p)h dehydrogenase (quinone) 1 , NAD(P)H:Quinone acceptor oxidoreductase type 1 , NAD(P)H:menadione oxidoreductase 1 , NAD(P)H:quinone oxireductase , diaphorase (NADH/NADPH) (cytochrome b-5 reductase) , diaphorase-4 , dioxin-inducible 1 , Diaphorase (NADH/NADPH) , NAD(P)H:menadione oxidoreductase , NAD(P)H dehydrogenase (quinone) , NAD(P)H menadione oxidoreductase 1, dioxin inducible , diaphorase 4 (NADH/NADPH) , nicotinamide adenine dinucleotide phosphate diaphorase , diaphorase 4 , NAD(P)H: quinone oxidoreductase 1

GENE ID SPECIES
322506 Danio rerio
468012 Pan troglodytes
549222 Xenopus (Silurana) tropicalis
705635 Macaca mulatta
769737 Gallus gallus
4606922 Azoarcus sp. BH72
5818094 Bordetella petrii DSM 12804
100049751 Xenopus laevis
100172039 Pongo abelii
100528193 Ictalurus punctatus
1728 Homo sapiens
610935 Canis lupus familiaris
24314 Rattus norvegicus
18104 Mus musculus
100286873 Sus scrofa
519632 Bos taurus
100135582 Cavia porcellus
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