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NADH Dehydrogenase (Ubiquinone) Flavoprotein 2, 24kDa Proteins (NDUFV2)

The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits.

list all proteins Gene Name GeneID UniProt
Human NDUFV2 NDUFV2 4729 P19404
Mouse NDUFV2 NDUFV2 72900 Q9D6J6
Rat NDUFV2 NDUFV2 81728 P19234
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Top NADH Dehydrogenase (Ubiquinone) Flavoprotein 2, 24kDa Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Escherichia coli (E. coli) Human GST tag NADH Dehydrogenase (Ubiquinone) Flavoprotein 2, 24kDa (NDUFV2) (AA 35-249), (partial) protein (GST tag) 1 mg Log in to see 60 to 71 Days
$1,842.50
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,539.17
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Yeast Chimpanzee His tag   1 mg Log in to see 60 to 71 Days
$2,539.17
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Yeast Pongo pygmaeus His tag   1 mg Log in to see 60 to 71 Days
$2,539.17
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,539.17
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Escherichia coli (E. coli) Human His tag   100 μg Log in to see 13 to 16 Days
$400.00
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More Proteins for NADH Dehydrogenase (Ubiquinone) Flavoprotein 2, 24kDa (NDUFV2) Interaction Partners

Human NADH Dehydrogenase (Ubiquinone) Flavoprotein 2, 24kDa (NDUFV2) interaction partners

  1. haplotype T-C consisting of rs12457810 and rs12964485 in the 5'-upstream region of NDUFV2 may be a protective factor for the development of MDD in Han Chinese

  2. We have identified NDUFV2 mutations in two families with Complex I deficiency, including a novel mutation.

  3. There is no statistical significance between NDUFV2 gene promoter variants and susceptibility to schizophrenia in Han Chinese.

  4. The mitochondrial targeting sequence of NDUFV2 is located at the N-terminus of the precursor protein. Impairment of mitochondrial localization of NDUFV2 as a mechanistic basis for early-onset hypertrophic cardiomyopathy and encephalopathy was established.

  5. Three single nucleotide polymorphisms in the NDUFV2 gene, were studies in bipolar disorder pateints and controls.

  6. Our findings suggest further studies addressing the role of NDUFV2 variation in Parkinson's disease may be warranted.

  7. Sp1 (show PSG1 Proteins) was abnormally expressed in schizophrenia and its mRNA alteration pattern paralleled that of NDUFV1 (show NDUFV1 Proteins) and NDUFV2 in schizophrenic patients.

  8. Polymorphisms in the promoter region of NDUFV2 are a genetic risk factor for bipolar disorder. The association of the haplotypes -602G> A and -3542G> A polymorphisms with bipolar disorder was seen both in Japanese case-control samples and NIMH trios.

  9. NDUFV2 individual genotypes were not associated with schizophrenia, but the haplotype consisting of the two single nucleotide polymorphisms were significantly associated with schizophrenia.

  10. genetic variants of NDUFV2 may increase risk for bipolar disorder.

Mouse (Murine) NADH Dehydrogenase (Ubiquinone) Flavoprotein 2, 24kDa (NDUFV2) interaction partners

  1. The results of this study indicated that ndufv2 knockdown influences the actin cytoskeleton and tubulin (show TUBB Proteins) stabilization in the leading process of migrating cortical neurons

  2. The authors biochemically separate the NADH dehydrogenase (show NDUFA2 Proteins) module from complex I of bovine heart into subunit I, II and III fractions. Subunit II fraction, also known as the NADH dehydrogenase (ubiquinone) flavoprotein 2 protein, has a molecular weight of 24 000 Da and contains an iron-sulfur center.

  3. The authors use green fluorescent-tagged complex I subunits to determine the kinetics of assembly. Tagged human NDUFV2 can replace the endogenous protein in the holo-complex I protein and was also found in complex I subassemblies, suggesting that NDUFV2 may directly incorporate into the holo-enzyme and may also assemble into smaller complexes or in a monomer pool.

  4. The authors provide an overview of the function and assembly of human complex I, also known as NADH dehydrogenase (show NDUFA2 Proteins) (ubiquinone) 1 alpha subcomplex. They discuss its role in oxidative phosphorylation and the implications of complex I deficiency in disease.

Cow (Bovine) NADH Dehydrogenase (Ubiquinone) Flavoprotein 2, 24kDa (NDUFV2) interaction partners

  1. Data show that during NADH-ubiquinone oxidoreductase (Complex (show NDUFA2 Proteins) I) catalytic electron transfer from NADH to DBQ, the superoxide generation site was mostly shifted to the SQ.

  2. Data suggest that Q(Nf) plays a role in a "direct" redox-driven proton pump, while Q(Ns) triggers an "indirect" conformation-driven proton pump in NADH-ubiquinone oxidoreductase (complex (show NDUFA2 Proteins) I).

  3. The catalytic function of NDH in the mediation of superoxide generation was investigated by EPR (show EREG Proteins) spin-trapping.

NADH Dehydrogenase (Ubiquinone) Flavoprotein 2, 24kDa (NDUFV2) Protein Profile

Protein Summary

The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19.

Gene names and symbols associated with NDUFV2

  • NADH:ubiquinone oxidoreductase core subunit V2 (NDUFV2)
  • NADH dehydrogenase (ubiquinone) flavoprotein 2 (Ndufv2)
  • NADH:ubiquinone oxidoreductase core subunit V2 (Ndufv2)
  • NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (LOC409793)
  • NADH:ubiquinone oxidoreductase core subunit V2 (ndufv2)
  • NADH dehydrogenase (ubiquinone) flavoprotein 2 (LOC657790)
  • NADH dehydrogenase (ndufv2)
  • NADH dehydrogenase [ubiquinone] flavoprotein 2,mitochondrial (NDUFV2)
  • NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa (Ndufv2)
  • NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa (NDUFV2)
  • NADH dehydrogenase (ubiquinone) flavoprotein 2 (ndufv2)
  • 2900010C23Rik protein
  • CI-24k protein
  • DDBDRAFT_0189294 protein
  • DDBDRAFT_0233206 protein
  • DDB_0189294 protein
  • DDB_0233206 protein
  • GB17038 protein
  • NuoE protein
  • zgc:73198 protein

Protein level used designations for NDUFV2

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial , NADH dehydrogenase ubiquinone flavoprotein 2, mitochondrial , NADH-ubiquinone oxidoreductase 24 kDa subunit , NADH-ubiquinone oxidoreductase flavoprotein 2 , complex I 24kDa subunit , complex I, mitochondrial respitory chain, 24 kD subunit , nuclear-encoded mitochondrial NADH-ubiquinone reductase 24Kd subunit , 24-kDa subunit of mitochondrial NADH dehydrogenase , NADH dehydrogenase flavoprotein 2 , NADH dehydrogenase subunit II , NADH-ubiquinone reductase 24 kDa mitochondrial , NADH dehydrogenase ubiquinone flavoprotein 2 , GLEAN_03690 , NADH dehydrogenase [ubiquinone] flavoprotein 2,mitochondrial , OXPHOS complex I 24 kDa subunit , NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa , NADH dehydrogenase flavoprotein 2, 24kDa

GENE ID SPECIES
4729 Homo sapiens
72900 Mus musculus
81728 Rattus norvegicus
282290 Bos taurus
409793 Apis mellifera
426488 Gallus gallus
455295 Pan troglodytes
480204 Canis lupus familiaris
549920 Xenopus (Silurana) tropicalis
657790 Tribolium castaneum
706067 Macaca mulatta
8628028 Dictyostelium discoideum AX4
10865442 Parachlamydia acanthamoebae UV-7
100037991 Sus scrofa
100115243 Nasonia vitripennis
100137466 Papio anubis
393720 Danio rerio
100719197 Cavia porcellus
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