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Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP.
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Human Polyclonal NHP2L1 Primary Antibody for ICC, IF - ABIN442692
Tresini, Warmerdam, Kolovos, Snijder, Vrouwe, Demmers, van IJcken, Grosveld, Medema, Hoeijmakers, Mullenders, Vermeulen, Marteijn: The core spliceosome as target and effector of non-canonical ATM signalling. in Nature 2015
Results solve the structure of a complex resulting from interaction between protein fragments of human NUFIP1 (show NUFIP1 Antibodies) and its cofactor ZNHIT3 (show ZNHIT3 Antibodies), and emphasize their imbrication. Also, it seems that the complexes involving NUFIP1 (show NUFIP1 Antibodies), ZNHIT3 (show ZNHIT3 Antibodies), and SNU13 share strong structural similarities between human and yeast, suggesting that the initial steps of the box C/D snoRNP assembly process are conserved among species.
NHPX is specifically accumulated in both nucleoli and Cajal bodies (CBs (show CBS Antibodies)) in vivo. The data show a specific temporal pathway involving the sequential and directed accumulation of NHPX in distinct subnuclear compartments
the testis-specific (show THEG Antibodies) expression of FA-1 (show FANCA Antibodies) antigen at the mRNA level
Data show that binding of the 15.5 kD RNA binding protein to the box C/D motif of snoRNAs is essential for the association of other snoRNP-associated proteins.
describe the solution NMR structure of free 15.5K, as well as studies of conformational flexibility from 15N NMR relaxation and H/D exchange experiments
snoRNP assembly factor NUFIP (show NUFIP1 Antibodies) can regulate the interactions between TIP48 (show RUVBL2 Antibodies) and TIP49 (show RUVBL1 Antibodies) and the core box C/D proteins.
Knockdown of endogenous nhp2l1 in zebrafish disrupts skeletal muscle development.
Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the
NHP2-like protein 1
, U4/U6.U5 tri-snRNP 15.5 kDa protein
, [U4/U6.U5] tri-snRNP 15.5 kD RNA binding protein
, high mobility group-like nuclear protein 2 homolog 1
, non-histone chromosome protein 2-like 1
, small nuclear ribonucleoprotein 15.5kDa (U4/U6.U5)
, sperm specific antigen 1
, fertilization antigen 1
, fertilization antigen-1
, sperm-specific antigen 1
, U4/U6.U5] tri-snRNP 15.5 kDa protein
, NHP2 non-histone chromosome protein 2-like 1