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Nop10 is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. Additionally we are shipping Nop10 Proteins (6) and many more products for this protein.
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Indian aplastic anemia patients did not have NOP10 mutations.
Effects of dyskeratosis congenita mutations in NOP10 on assembly of H/ACA pre-RNPs
NOP10 has a role in the telomerase complex and telomere maintenance, and in autosomal recessive dyskeratosis congenita
Nop10 loss results in 18S rRNA processing defects and collapse of the small ribosomal subunit, coupled to stabilization of the p53 tumor suppressor protein (show TP53 Antibodies) through small ribosomal proteins binding to Mdm2 (show MDM2 Antibodies).
This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p.
H/ACA ribonucleoprotein complex subunit 3
, NOP10 ribonucleoprotein homolog
, homolog of yeast Nop10p
, nucleolar protein 10
, nucleolar protein family A member 3
, nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs)
, snoRNP protein NOP10
, H/ACA small nucleolar RNPs
, nucleolar protein family A, member 3