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Promotes loss of intracellular domain (ICD) of Notch1 in embryos. Additionally we are shipping NRARP Proteins (7) and NRARP Kits (6) and many more products for this protein.
Showing 10 out of 53 products:
Human Polyclonal NRARP Primary Antibody for WB - ABIN4890861
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002
High NRARP expression is associated with papillary thyroid carcinoma progression.
Downregulation of NRARP expression exerts significant antitumor activities against cell growth and invasion of thyroid cancer, that suggests a potential role of NRARP in thyroid cancer targeted therapy.
NRARP may stimulate cell proliferation in human breast cancer.
The transcription and expression patterns of Notch (show NOTCH1 Antibodies) pathway components (Notch 1 (show NOTCH1 Antibodies)-3, Delta1 and 4, Jagged1 (show JAG1 Antibodies)) and effectors (Hes1 (show HES1 Antibodies), Hes2 (show HES2 Antibodies), Hes5 (show HES5 Antibodies) and Nrarp) were evaluated in the mouse testis
Nrarp is essential for forming the proper number and morphology of axial skeleton components
Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate.
Different effects of Nrarp overexpression suggest that alternate Notch (show NOTCH1 Antibodies) signaling pathways mediate T- versus B-cell lineage commitment and thymocyte maturation.
Results show that the Notch-regulated ankyrin repeat protein (Nrarp) acts as a molecular link between Notch (show NOTCH1 Antibodies)- and Lef1 (show LEF1 Antibodies)-dependent Wnt (show WNT2 Antibodies) signaling in endothelial cells to control stability of new vessel connections in mouse and zebrafish.
please add ref (show THOC4 Antibodies) to Xenopus: 2002 Mechanisms of Development 110, 113-124. Where they call it "Xnap"
Promotes loss of intracellular domain (ICD) of Notch1 in embryos. By down-regulating ICD levels, could function as a negative feedback regulator of Notch signaling that attenuates ICD-mediated transcription.
notch-regulated ankyrin repeat-containing protein