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Promotes loss of intracellular domain (ICD) of Notch1 in embryos. Additionally we are shipping NRARP Proteins (8) and NRARP Kits (6) and many more products for this protein.
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The transcription and expression patterns of Notch pathway components (Notch 1-3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated in the mouse testis
Nrarp is essential for forming the proper number and morphology of axial skeleton components
Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate.
Different effects of Nrarp overexpression suggest that alternate Notch signaling pathways mediate T- versus B-cell lineage commitment and thymocyte maturation.
Results show that the Notch-regulated ankyrin repeat protein (Nrarp) acts as a molecular link between Notch- and Lef1-dependent Wnt signaling in endothelial cells to control stability of new vessel connections in mouse and zebrafish.
please add ref to Xenopus: 2002 Mechanisms of Development 110, 113-124. Where they call it "Xnap"
High NRARP expression is associated with papillary thyroid carcinoma progression.
Downregulation of NRARP expression exerts significant antitumor activities against cell growth and invasion of thyroid cancer, that suggests a potential role of NRARP in thyroid cancer targeted therapy.
NRARP may stimulate cell proliferation in human breast cancer.
Promotes loss of intracellular domain (ICD) of Notch1 in embryos. By down-regulating ICD levels, could function as a negative feedback regulator of Notch signaling that attenuates ICD-mediated transcription.
notch-regulated ankyrin repeat-containing protein
, notch-regulated ankyrin repeat-containing protein A