NPC1L1 Proteins

The protein encoded by NPC1L1 is a multi-pass membrane protein.

Data Quality
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Type
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    Protein
Antigen
  • 10
Reactivity
  • 6
  • 4
Application
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  • 9
Host
  • 8
  • 2
Binding Specificity
  • 1
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Conjugate
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  • 2
Protein Type
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Format
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10 Products
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3084683
$5,227.64
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 30 to 35 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3084681
$6,570.39
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 50 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3084682
$6,570.39
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 50 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3084680
$6,570.39
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 50 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse (Murine)
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3123829
$6,570.39
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 50 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse (Murine)
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3123830
$6,570.39
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 50 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse (Murine)
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3123831
$6,570.39
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 50 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse (Murine)
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3135841
$10,931.48
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 70 to 75 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3094226
$15,592.82
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 70 to 75 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity 50 %
ReactivityHuman
Order details Cat. No. ABIN2854025
$1,169.22
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 15 to 17 Business Days
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NPC1L1 Protein Profile

Protein Summary

The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NPC1L1

  • NPC1 like intracellular cholesterol transporter 1 (NPC1L1) antibody
  • NPC1 like 1 (npc1l1) antibody
  • NPC1-like 1 (npc1l1) antibody
  • NPC1 like intracellular cholesterol transporter 1 (Npc1l1) antibody
  • 9130221N23Rik antibody
  • Gm243 antibody
  • NPC1L1 antibody
  • NPC11L1 antibody

Protein level used designations for NPC1L1

NPC1-like 1 , NPC1 (Niemann-Pick disease, type C1, gene)-like 1 , Niemann-Pick C1-like protein 1 , Niemann-Pick C1-like 1 protein , Niemann-Pick C1-like protein 1-like , Niemann-Pick disease, type C1 , Niemann-Pick disease, type C1-like 1

GENE ID SPECIES
463381 Pan troglodytes
539550 Bos taurus
610398 Canis lupus familiaris
699235 Macaca mulatta
100009042 Oryctolagus cuniculus
100030165 Monodelphis domestica
100458187 Pongo abelii
100478497 Ailuropoda melanoleuca
100487339 Xenopus (Silurana) tropicalis
100515982 Sus scrofa
100590536 Nomascus leucogenys
100616532 Danio rerio
237636 Mus musculus
432367 Rattus norvegicus
29881 Homo sapiens