anti-Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) Antibodies

NPR2 encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Additionally we are shipping NPR2 Proteins (19) and NPR2 Kits (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NPR2 230103 Q6VVW5
NPR2 4882 P20594
NPR2 116564 P16067
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Top anti-NPR2 Antibodies at

Showing 10 out of 89 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis NPR2 using COLO205 whole cell lysates 100 μL 11 to 12 Days
Human Mouse Un-conjugated ELISA, IHC, IHC (p), WB Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-NPR2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-NPRB/Natriuretic Peptide Receptor B Polyclonal Antibody, Unconjugated (ABIN679778) at 1:200 followed by conjugation to the secondary antibody 100 μL 3 to 7 Days
Mouse Rabbit Un-conjugated WB Western Blot at 1:1000 dilution + mouse heart lysate Lysates/proteins at 20 ug per lane. 400 μL 2 to 3 Days
Human Rabbit Un-conjugated IHC (fro), WB 0.1 mL 6 to 8 Days
Bat Rabbit Un-conjugated ELISA, WB   100 μL 11 to 14 Days
Human Mouse Un-conjugated EIA, IHC (p), WB 50 μg 6 to 8 Days
Human Rabbit Alexa Fluor 594 IF (p)   100 μL 14 to 21 Days
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged NPR2 is 3 ng/ml as a capture antibody. 100 μg 11 to 12 Days
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to NPR2 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml] Western Blot detection against Immunogen (36.74 KDa) . 100 μg 11 to 12 Days

Top referenced anti-NPR2 Antibodies

  1. Human Polyclonal NPR2 Primary Antibody for IF (p), IHC (p) - ABIN679778 : Li, Tang, Cai, Qiu, Lin, Zhu, Owusu, Guo: CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan. in World journal of gastroenterology : WJG 2015 (PubMed)

More Antibodies against NPR2 Interaction Partners

Mouse (Murine) Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) interaction partners

  1. Phosphorylation of specific serine and threonine residues in juxtamembrane regions of Npr2 are required for its enzymatic activity and for axon bifurcation.

  2. Myofibrogenesis in cultured Npr2(+/)(-) fibroblasts was insensitive to CNP treatment. Aged Npr2(+/)(-) and Npr2(+/)(-);Ldlr-/- mice developed cardiac dysfunction and ventricular fibrosis. Aortic valve function was impaired in Npr2(+/)(-) and Npr2(+/)(-);Ldlr(-/)(-) mice, with increased valve thickening, myofibrogenesis, osteogenesis, proteoglycan synthesis, collagen accumulation and calcification.

  3. elevated in ovaries of polycystic ovary syndrome model

  4. It was the aim to investigate the expression of natriuretic peptide receptors NPR-A, NPR-B and NPR-C during adipocyte differentiation (AD), upon stimulation with fatty acids (FA), and in murine and human adipose tissue depots.

  5. the present study indicates that CNP and its cognate receptor NPR2 mainly expressed in neurons represent an innate neuroprotective mechanism in neonatal hypoxia-ischemia brain injury.

  6. The authors show that fibroblast growth factor-induced dephosphorylation of NPR2 decreases its guanylyl cyclase activity in growth plate chondrocytes in living bone.

  7. E2-ERs system was functional in maintaining oocyte meiotic arrest by regulating the expression of natriuretic peptide C and natriuretic peptide receptor 2 (NPPC/NPR2)

  8. NPR2 is involved in FSH-mediated oocyte meiotic resumption, and this process is associated with the EGFR and MAPK3/1 signaling pathways.

  9. NPR2 dephosphorylation in the mural granulosa cells is essential for the normal progression of meiosis in response to LH and EGF receptor activation.

  10. Npr2 is necessary for the precise spatial organization typical of central auditory circuits, but signals are still transmitted with normal timing, and that mutant mice can hear even with these deficits.

  11. Npr2 is expressed in hard calluses of wild-type mice, suggesting a possible role of CNP signaling in fracture repair, especially in bone remodeling stage.

  12. Data, including data from mutant mice strain Npr2(slw/slw), suggest that Npr2 is critical for fertility but role of Npr2 may be more involved in penile function rather than involved in spermatogenesis.

  13. These findings demonstrate that pNPPB may be used as a probe to identify the essential amino acid sequences for activation of NPR2.

  14. GATA2 and Lmo2 cooperatively regulate VEGF-induced angiogenesis and lymphangiogenesis via NRP2.

  15. Data suggest that epidermal growth factor (Egf)/Egf receptor signaling in cumulus cells (CC) down-regulates Npr2, decreases cGMP, elevates calcium, and induces meiotic resumption/oogenesis in cultured CC-oocyte complexes (in induced meiotic arrest).

  16. CNP/NPR2 signaling is essential for oocyte meiotic arrest in early antral follicles and activated LH/amphiregulin/EGFR signaling pathway suppresses this signal by downregulating Nppc expression.

  17. NPPC/NPR2 signaling is essential for oocyte meiotic arrest and cumulus oophorus formation, which affects female fertility through the production of oocytes with developmental capacity.

  18. Cellular exposure to Go6976 reduced basal and natriuretic peptide-dependent, but not detergent-dependent, GC-A and GC-B activity.

  19. These observations suggest that the CNP/GC-B system participates in regulation of adipogenesis, particularly at an early stage in the process.

  20. Data suggest that the gastrointestinal tract dysfunction phenotype of slw/slw mice is because of a C-type natriuretic peptide/natriuretic peptide receptor B-signaling defect caused by an Npr2 mutation.

Human Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) interaction partners

  1. It was the aim to investigate the expression of natriuretic peptide receptors NPR-A, NPR-B and NPR-C during adipocyte differentiation (AD), upon stimulation with fatty acids (FA), and in murine and human adipose tissue depots.

  2. homozygous mutations in the NPR2 gene underlying variable phenotypes of Acromesomelic dysplasia, type Maroteaux

  3. These results of the distinct presence of NPRA and NPRBpositive cells in unstable plaques underlying acute myocardial infarction suggested that natriuretic peptides serve a role in regulating plaque instability in humans.

  4. Atenolol treatment normalized the altered expression of Npr1 and Npr2 genes.

  5. Data suggest mutations in NPR2 in patients with skeletal overgrowth alter conformation: A488P/R655C missense mutations yield conformation mimicking allosterically activated NPR2; A488P mutation sets phosphorylation as requirement for CNP-dependent activation; R655C mutation abrogates need for phosphorylation; ATP analog inhibits mutants. (NPR2 = atrial natriuretic factor receptor B; CNP = C-type natriuretic peptide)

  6. in 4 Indian families with acromesomelic dysplasia, type Maroteaux, 4 homozygous mutations in four different families were identified; these include 3 novel mutations including a deletion frameshift mutation (p.Cys586Ter), one nonsense mutation (p.Arg479Ter), one missense mutation (p.Val187Asp) and one reported missense mutation (p.Tyr338Cys)

  7. Heterozygous mutation in NPR2 gene is associated with short stature.

  8. Mutations in three genes (GDF5, NPR2, BMPR1B) have been reported to cause different forms of acromesomelic dysplasia

  9. IL1R2 hypomethylation and androgen receptor hypermethylation may constitute an important determinant of disease severity, whereas NPR2 hypomethylation and SP140 hypermethylation may provide a biomarker for vulnerability to excessive daytime sleepiness in Obstructive Sleep Apnea

  10. Loss-of-function mutations of the NPR2 gene is associated with acromesomelic dysplasia, type maroteaux.

  11. Heterozygous mutations in natriuretic peptide receptor-B (NPR2) gene as a cause of short stature

  12. NPR2 mutations account for approximately 3% of patients with disproportionate short stature and/or clinical or radiographic indicators of SHOX deficiency and in whom no SHOX defect has been identified.

  13. 3 consanguineous families segregating Acromesomelic dysplasia Maroteaux type in an autosomal recessive manner studied. Linkage in the families was established to the NPR2 gene on chromosome 9p12-21. Sequence analysis revealed 2 novel missense variants (p.Arg601Ser; p.Arg749Trp) in 2 families and a previously reported splice site variant (c.2986+2T>G) in the third family.

  14. Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A/-B activator.

  15. Overgrowth syndrome associated with a gain-of-function mutation of the natriuretic peptide receptor 2 (NPR2) gene.

  16. Gene expression of C-type natriuretic peptide and of its specific receptor NPR-B in human leukocytes of healthy and heart failure subjects

  17. Molecular dynamics analysis indicated decreases in the values of Van der Waals, electrostatic energy and potential energy of NPRB/Vasonatrin peptide compared to NPRA/Vasonatrin peptide.

  18. Identification of heterozygous dominant negative NPR2 mutations in 2% of Japanese patients with short stature.

  19. KIdney NPR2 protein quantity is significantly impacted by genetic variation.

  20. study concludes V883M mutation increases maximal velocity in absence of C-type natriuretic peptide (CNP), eliminates requirement for ATP in the CNP-dependent Km reduction and disrupts normal inactivation process; established a molecular mechanism for how an amino acid substitution in GC-B activates the enzyme, which results in abnormally long and fragile bones

Cow (Bovine) Natriuretic Peptide Receptor B/guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) (NPR2) interaction partners

  1. These data support the existence of a novel transducing cascade, involving Galpha(q16)beta gamma coupling M(3)AChR to NPR-GC.

  2. NPR-B is a highly regulated nano-machinery with domains acting at cross-talk points with other signal transducing cascades initiated by G protein-coupled receptors

  3. ATP is not required for the initial activation of natriuretic peptide receptor A and B, but does increase activity over time by reducing the apparent K(m) for GTP.

NPR2 Antigen Profile

Protein Summary

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.

Gene names and symbols associated with NPR2

  • natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) (NPR2) antibody
  • natriuretic peptide receptor 2 (Npr2) antibody
  • natriuretic peptide receptor 2 (NPR2) antibody
  • AMDM antibody
  • ANPb antibody
  • ANPRB antibody
  • cn antibody
  • GC-B antibody
  • GC-B2 antibody
  • GC-B3 antibody
  • GUC2B antibody
  • GUCY2B antibody
  • mNPR-B antibody
  • NPR-B antibody
  • NPR2 antibody
  • NPRB antibody
  • NPRBi antibody
  • pwe antibody

Protein level used designations for NPR2

natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) , natriuretic peptide receptor 2 , ANP-B , ANPR-B , NPR-B , Nppb receptor , atrial natriuretic peptide receptor 2 , atrial natriuretic peptide receptor type B , guanylate cyclase B , guanylyl cyclase-B , natriuretic peptide receptor B type , GC-B , atrial natriuretic peptide B-type receptor , ANPRB , atrial natriuretic peptide receptor B , natriuretic peptide receptor-B , atrionatriuretic peptide receptor B

692193 Sus scrofa
230103 Mus musculus
4882 Homo sapiens
116564 Rattus norvegicus
281357 Bos taurus
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