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NPR2 encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Additionally we are shipping NPR2 Antibodies (75) and NPR2 Kits (22) and many more products for this protein.
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E2-ERs system was functional in maintaining oocyte meiotic arrest by regulating the expression of natriuretic peptide C and natriuretic peptide receptor 2 (NPPC/NPR2 (show NPRL2 Proteins))
NPR2 (show NPRL2 Proteins) is involved in FSH (show BRD2 Proteins)-mediated oocyte meiotic resumption, and this process is associated with the EGFR (show EGFR Proteins) and MAPK3 (show MAPK3 Proteins)/1 signaling pathways.
NPR2 (show NPRL2 Proteins) dephosphorylation in the mural granulosa cells is essential for the normal progression of meiosis in response to LH and EGF receptor (show EGFR Proteins) activation.
Npr2 (show NPRL2 Proteins) is necessary for the precise spatial organization typical of central auditory circuits, but signals are still transmitted with normal timing, and that mutant mice can hear even with these deficits.
Npr2 (show NPRL2 Proteins) is expressed in hard calluses of wild-type mice, suggesting a possible role of CNP (show CNP Proteins) signaling in fracture repair, especially in bone remodeling stage.
Data, including data from mutant mice strain Npr2 (show NPRL2 Proteins)(slw/slw), suggest that Npr2 (show NPRL2 Proteins) is critical for fertility but role of Npr2 (show NPRL2 Proteins) may be more involved in penile function rather than involved in spermatogenesis.
These findings demonstrate that pNPPB may be used as a probe to identify the essential amino acid sequences for activation of NPR2 (show NPRL2 Proteins).
GATA2 (show GATA2 Proteins) and Lmo2 (show LMO2 Proteins) cooperatively regulate VEGF (show VEGFA Proteins)-induced angiogenesis and lymphangiogenesis via NRP2 (show NRP2 Proteins).
Data suggest that epidermal growth factor (Egf)/Egf (show EGF Proteins) receptor (show EGFR Proteins) signaling in cumulus cells (CC) down-regulates Npr2 (show NPRL2 Proteins), decreases cGMP, elevates calcium, and induces meiotic resumption/oogenesis in cultured CC-oocyte complexes (in induced meiotic arrest).
CNP/NPR2 signaling is essential for oocyte meiotic arrest in early antral follicles and activated LH/amphiregulin/EGFR signaling pathway suppresses this signal by downregulating Nppc expression.
Atenolol treatment normalized the altered expression of Npr1 (show NPR1 Proteins) and Npr2 (show NPRL2 Proteins) genes.
Data suggest mutations in NPR2 in patients with skeletal overgrowth alter conformation: A488P/R655C missense mutations yield conformation mimicking allosterically activated NPR2; A488P mutation sets phosphorylation as requirement for CNP-dependent activation; R655C mutation abrogates need for phosphorylation; ATP analog inhibits mutants. (NPR2 = atrial natriuretic factor receptor B; CNP = C-type natriuretic peptide)
Heterozygous mutation in NPR2 (show NPRL2 Proteins) gene is associated with short stature.
Mutations in three genes (GDF5 (show GDF5 Proteins), NPR2 (show NPRL2 Proteins), BMPR1B (show BMPR1B Proteins)) have been reported to cause different forms of acromesomelic dysplasia
IL1R2 (show IL1R2 Proteins) hypomethylation and androgen receptor (show AR Proteins) hypermethylation may constitute an important determinant of disease severity, whereas NPR2 (show NPRL2 Proteins) hypomethylation and SP140 (show SP140 Proteins) hypermethylation may provide a biomarker for vulnerability to excessive daytime sleepiness in Obstructive Sleep Apnea
Loss-of-function mutations of the NPR2 (show NPRL2 Proteins) gene is associated with acromesomelic dysplasia, type maroteaux.
NPR2 (show NPRL2 Proteins) mutations account for approximately 3% of patients with disproportionate short stature and/or clinical or radiographic indicators of SHOX (show SHOX Proteins) deficiency and in whom no SHOX (show SHOX Proteins) defect has been identified.
3 consanguineous families segregating Acromesomelic dysplasia Maroteaux type in an autosomal recessive manner studied. Linkage in the families was established to the NPR2 (show NPRL2 Proteins) gene on chromosome 9p12-21. Sequence analysis revealed 2 novel missense variants (p.Arg601Ser; p.Arg749Trp) in 2 families and a previously reported splice site variant (c.2986+2T>G) in the third family.
Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A (show NPR1 Proteins)/-B activator.
Gene expression of C-type natriuretic peptide and of its specific receptor NPR-B in human leukocytes of healthy and heart failure subjects
These data support the existence of a novel transducing cascade, involving Galpha (show SUCLG1 Proteins)(q16)beta gamma coupling M(3)AChR to NPR (show NPTXR Proteins)-GC.
NPR-B is a highly regulated nano-machinery with domains acting at cross-talk points with other signal transducing cascades initiated by G protein-coupled receptors
ATP is not required for the initial activation of natriuretic peptide receptor A (show NPR1 Proteins) and B, but does increase activity over time by reducing the apparent K(m) for GTP (show AK3 Proteins).
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
, natriuretic peptide receptor 2
, Nppb receptor
, atrial natriuretic peptide receptor 2
, atrial natriuretic peptide receptor type B
, guanylate cyclase B
, guanylyl cyclase-B
, natriuretic peptide receptor B type
, atrial natriuretic peptide B-type receptor
, atrial natriuretic peptide receptor B
, natriuretic peptide receptor-B
, atrionatriuretic peptide receptor B