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May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system..
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These data support part of our hypothesis that NHLH2 or MAO-A (show MAOA ELISA Kits) polymorphism is associated with sedentary behavior.
Leptin (show LEP ELISA Kits) signaling regulates hypothalamic expression of Nhlh2 through Stat3 (show STAT3 ELISA Kits).
Two single nucleotide polymorphisms in the human nescient helix-loop-helix 2 (NHLH2) gene reduce mRNA stability or reduce helical structure in the DNA binding domain of the protein.
The present results suggest that a transcriptional complex of LMO3 (show LMO3 ELISA Kits) and HEN2 may contribute to the genesis and malignant phenotype of neuroblastoma by inhibiting HES1 (show HES1 ELISA Kits) which suppresses the transactivation of Mash1 (show ASCL1 ELISA Kits).
The deregulated expression of neuronal-specific LMO3 and HEN2 contributes to the genesis and progression of human neuroblastoma in a lineage-specific manner.
proposes the novel hypothesis that transcriptional activity by Nhlh2 (NHLH2 in humans) controls either the ability or the motivation for exercise [review]
suggested that the expression levels of Lmo3 (show LMO3 ELISA Kits) and/or Hen2 could determine the fate of stem cells by inhibiting Hes1 (show HES1 ELISA Kits) function during nervous system development and might be a trigger of aberrant neurogenesis in vivo
We found that loss of Nscl-2 results in aberrant migration of gonadotropin releasing hormone neurons in Nscl-2 mutant mice causing a lineage switch of ectopically located gonadotropin releasing hormone neurons
Melanocortin 4 receptor (show MC4R ELISA Kits) is a transcriptional target of nescient helix-loop-helix-2
Nhlh2 in the central control of adipocyte function
Nhlh2 transcription factor has a role in controlling genes important to energy expenditure, and more specifically voluntary physical activity of animals
Regulation of body weight is linked to action of neuronal Nhlh2 on prohormone convertase mRNA levels. Direct role for transcriptional control of neuropeptide processing enzymes in etiology of adult-onset obesity.
N2KO mice (with targeted deletion of Nhlh2)have fewer pregnancies, abnormal estrus cycles, and release fewer oocytes as they age. N2KO females show at least a 50% reduction in hormone-stimulated sexual behavior as measured by their lordosis quotient.
Data show that NSCL-1 (show NHLH1 ELISA Kits) and -2, together with additional cofactors, directly control transcription of the necdin (show NDN ELISA Kits) gene.
We conclude that NSCL-1 (show NHLH1 ELISA Kits)/2 maintain migration and survival of cells in the migratory stream to the cerebellum.
Nhlh2 plays a role in the development and functional maintenance of the hypothalamic-pituitary-gonadal axis
The bovine Nhlh2 gene (bNHLH2) is cloned and shown to be highly conserved among bovine breeds.
May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
helix-loop-helix protein 2
, nescient helix loop helix 2
, class A basic helix-loop-helix protein 34