Neurofilament, Heavy Polypeptide Proteins (NEFH)

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Additionally we are shipping Neurofilament, Heavy Polypeptide Antibodies (448) and Neurofilament, Heavy Polypeptide Kits (42) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NEFH 380684 P19246
Rat NEFH NEFH 24587  
NEFH 4744 P12036
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Top Neurofilament, Heavy Polypeptide Proteins at

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Cow Cow Un-conjugated   100 μg Log in to see 6 to 8 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days

NEFH Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for Neurofilament, Heavy Polypeptide (NEFH) Interaction Partners

Mouse (Murine) Neurofilament, Heavy Polypeptide (NEFH) interaction partners

  1. Data indicate the presence of a HuD (show ELAVL4 Proteins) - BDNF (show BDNF Proteins) - NF-H pathway activated as a regenerative response to the axonal damage induced by antiretroviral treatment to counteract the antiretroviral neurotoxicity.

  2. Microgravity causes substantial down-regulation of nerve tissue proteins, choline acetyltransferase, NF200, and calbindin (show CALB1 Proteins) in mouse motor neurons.

  3. Data conclude that NF-H and NF-M (show CEBPB Proteins) C-terminal domains do not normally regulate NF transport rates as previously proposed, but instead increase the proteolytic resistance of NF, thereby stabilizing the stationary neurofilament cytoskeleton along axons.

  4. plasma NfH levels closely reflect later stages of disease progression and therapeutic response in the SOD1 (show SOD1 Proteins)(G93A) mouse model of amyotrophic lateral sclerosis

  5. NFH expression reveals an exquisite level of Cb stripe complexity that respects the transverse zone divisions and delineates an intricately patterned target field for Cb afferents.

  6. results obtained in mouse model for leprous neuropathy indicate biochemical alterations in neurofilaments, i.e., hyperphosphorylation of NF-H and NF-M (show CEBPB Proteins)

  7. Overexpression of peripherin (show PRPH Proteins) in mice deficient for neurofilament light (NF-L (show NEFL Proteins)) subunits induced a progressive ALS-like spinal motor neuron degeneration prevented by simultaneous overexpression of NF-H

  8. NF-H regulates the association of NFs with kinesin. Phosphorylation of NF-H dissociates NFs from kinesin and provides a mechanism by which NF-H phosphorylation can contribute to the slowing of NF axonal transport.

  9. Alpha-internexin (show INA Proteins) coassembles with all 3 neurofilament proteins into a single network of filaments in quadruple-transfected cells. Deleting NF-M (show CEBPB Proteins) alone or together with NF-H in mice reduces alpha-internexin (show INA Proteins) transport & content in axons throughout the CNS.

  10. We have validated the serum pNF-H assay as an unbiased measurement of axonal injury in EAE, facilitating rapid screening of potential neuroprotective therapies in this model.

Human Neurofilament, Heavy Polypeptide (NEFH) interaction partners

  1. Data suggest that high CSF (show CSF2 Proteins) NfH levels are an early predictor of later brain and spinal cord atrophy in multiple sclerosis patients.

  2. Findings in the dorsolateral prefrontal cortex in schizophrenia provide evidence of altered proteins involved in synaptic function (FABP4 (show FABP4 Proteins)), cytoarchitecture organization (NEFH), and circadian molecular clock signaling (CSNK1E (show CSNK1E Proteins)), which may be contributing to the cognitive and/or negative symptoms in this disorder. FABP4 (show FABP4 Proteins), CSNK1E (show CSNK1E Proteins) and NEFH could become potentially useful biomarkers for schizophrenia.

  3. Unique deletions of two nucleotides causing frameshifts near the end of the NEFH coding sequence were identified in two Charcot-Marie-Tooth disease families. Using electroporation of chick embryo spinal cord, confirmed that NEFH mutants form aggregates in vivo and trigger apoptosis of spinal cord neurons.

  4. This study confirmed the general applicability of the monocentric obtained cut-off values for neurofilamens in ALS, especially for pNfH

  5. data support the use of Cebrospinal fluid phosphorylated NFH as a prognostic biomarker for amyotrophic lateral sclerosis.

  6. Study found a significant correlation between values of 8-hydroxy-2'-deoxyguanosine and phosphorylated NF-H only in clinically isolated syndrome group. While the plasma values of 8-hydroxy-2'-deoxyguanosine reflect the degree of acute demyelination in clinically isolated syndrome, phosphorylated NF-H values reflect that in relapsing-remitting multiple sclerosis.

  7. Results provide evidence that in particular pNfH can be used as a good diagnostic biomarker of ALS (show IGFALS Proteins) at the diagnostic stage. Moreover, results indicate that NfL (show NEFL Proteins) may be useful in monitoring disease progression in a subset of patients.

  8. Level of neurofilament heavy chain and light chains were significantly elevated in the cerebrospinal fluid of Amyotrophic Lateral Sclerosis (ALS) patients compared to healthy controls/controls without parenchymal central nervous system involvement and ALS mimic disease patients.

  9. Study found a significant increase of pNF-H levels in both plasma and CSF (show CSF2 Proteins) in amyotrophic lateral sclerosis patients

  10. Studied diagnostic Value of Serum Levels of GFAP (show GFAP Proteins), pNF-H, and NSE (show ENO2 Proteins) Compared With Clinical Findings in Severity Assessment of Human Traumatic Spinal Cord Injury.

Neurofilament, Heavy Polypeptide (NEFH) Protein Profile

Protein Summary

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.

Gene names and symbols associated with NEFH

  • neurofilament heavy polypeptide (MCYG_06231)
  • neurofilament, heavy polypeptide (Nefh)
  • neurofilament heavy (Nefh)
  • neurofilament heavy (NEFH)
  • neurofilament heavy polypeptide (NEFH)
  • mKIAA0845 protein
  • NEFH protein
  • NF-H protein
  • NF200 protein
  • NFH protein

Protein level used designations for NEFH

neurofilament heavy polypeptide , 200 kDa neurofilament protein , neurofilament 200kDa , neurofilament triplet H protein , NF-H , neurofilament, heavy polypeptide 200kDa , neurofilament, heavy polypeptide , neurofilament, heavy polypeptide 200kDa-like , heavy neurofilament protein , intermediate filament protein

9222506 Arthroderma otae CBS 113480
380684 Mus musculus
24587 Rattus norvegicus
4744 Homo sapiens
100156492 Sus scrofa
528842 Bos taurus
442940 Canis lupus familiaris
417020 Gallus gallus
100716406 Cavia porcellus
101107472 Ovis aries
101087272 Felis catus
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