Neurogenin 1 Proteins (NEUROG1)

Mouse (Murine) Neurogenin 1 (NEUROG1) interaction partners

1. CTCF (show CTCF Proteins) plays an essential role in otic neurogenesis by modulating histone modification in the Neurog1 locus.

2. NEUROG1 promotes proliferation and neuronal differentiation in otic progenitors via regulation of CDK2 (show CDK2 Proteins) expression.

3. Ngn1 binds to the promoter of a brain-enriched microRNA, miR (show MLXIP Proteins)-9, and activates its expression during neurogenesis.

4. Neurog1-CreER GIFM reveals a correlation between the timing of Neurog1 expression and the spatial organization of GABAergic neurons in the cerebellar cortex.

5. Neurog1 can partially substitute for Atoh1 (show ATOH1 Proteins) function in hair cell differentiation and maintenance during organ of Corti development.

6. Neurog1 and Neurog2 (show NEUROG2 Proteins) have unique and redundant functions in the piriform cortex, controlling the timing of differentiation of neurons

7. ESC expressing Neurogenin1 begin to withdraw from cycle and form precursors that differentiate exclusively into neurons.

8. Netrin-1 (show NTN1 Proteins) serves as an attractive guidance cue for Neurog1-induced cells and that this effect is likely mediated by DCC (show DCC Proteins) receptor expressed in the growth cones of neurons.

9. Neurog1/2 together coordinate development of the olfactory system, which depends on tissue interactions between the olfactory bulb and epithelium.

10. A noncoding RNA transcribed from an enhancer element positively regulates transcription at the Neurog1 locus.

Human Neurogenin 1 (NEUROG1) interaction partners

1. NeuroD1 (show NEUROD1 Proteins) seemed not sufficient to induce and maintain neuronal differentiation. Induction of neuronal differentiation by overexpression of Neurog1 initiated important steps for the development of glutamatergic neurons such as the spiral ganglion neurons

2. Results show that neurogenin-1 and -2 drive homogeneous differentiation of human stem cells into bipolar neurons in 4 days in defined media.

3. We propose NEUROG1 as a new gene for syndromic autosomal recessive hearing loss and congenital cranial dysinnervation disorder

4. Methylation of NEUROG1 is associated with recurrence following adjuvant FOLFOX in Stages II/III colorectal cancer.

5. NEUROG1 gene is frequently found in patients, diagnosed with colorectal cancer.

6. Stable expression of a single gene Ngn1 in F3 cells induces not simply neurogenic but multifunctional changes that potentially affect the differentiation of human NSC via a reorganization of complex gene regulatory networks.

7. The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a "fuzzy" complex upon DNA binding.

8. Overexpression of the full-length Ngn1 induced neurite outgrowth in F11 (show F11 Proteins) cells in the absence of cAMP

9. These results, along with a priori evidence for the involvement of neurog1 in neurodevelopment, suggest that variants in neurog1 might have a small effect on susceptibility to schizophrenia.

10. Major alleles on two NEUROG1-associated SNPs (rs2344484-C-allele and rs8192558-G-allele) were significantly more prevalent among patients. this is the first study to examine brain morphological and neurocognitive correlates of NEUROG1.

Zebrafish Neurogenin 1 (NEUROG1) interaction partners

1. zebrafish Dmrta2 controls neurogenin1 expression by repressing her6 in the posterior-dorsal telencephalon

2. Id3 (show ID3 Proteins) was expressed specifically in a subset of DA neurons in the ventral diencephalon, with co-expression of neurogenin1 (Ngn1).

3. an Ngn1-responsive cis (show CISH Proteins)-regulatory modules at the zebrafish deltaA locus that functions via the non-redundant interaction of three consensus Ngn E-boxes were identified.

4. neurogenin1 (ngn1) is required for the development of all zebrafish cranial ganglia

5. regulatory sequences with temporally and spatially distinct activities control ngn1 expression in primary neurons of the zebrafish embryo. These regions are highly similar to 5' sequences in the mouse and human ngn1 gene

6. ash1a and ngn1 function in parallel redundant pathways to regulate neurogenesis downstream of flh

7. In zebrafish, TCDD reduces embryonic brain development due to decreased expression of neurogenin and sonic hedgehog (show SHH Proteins).

8. Data suggest that Her5 acts as a prepattern gene to suppress both neurogenin1 (ngn1) and coe2 (show EBF2 Proteins) mRNA expression and to prevent neurogenesis in the anlage of the midbrain/hindbrain boundary in the zebrafish neural plate.

9. the upstream region of zebrafish ngn1 is capable of faithfully recapitulating endogenous expression in the zebrafish and mouse telencephalon

10. global 'Him+Her5' activity inhibits ngn1 expression in a dose-dependent manner and through different sensitivity thresholds along the medio-lateral axis of the neural plate