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CTCF plays an essential role in otic neurogenesis by modulating histone modification in the Neurog1 locus.
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NEUROG1 promotes proliferation and neuronal differentiation in otic progenitors via regulation of CDK2 expression.
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Ngn1 binds to the promoter of a brain-enriched microRNA, miR-9, and activates its expression during neurogenesis.
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Neurog1-CreER GIFM reveals a correlation between the timing of Neurog1 expression and the spatial organization of GABAergic neurons in the cerebellar cortex.
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Neurog1 can partially substitute for Atoh1 function in hair cell differentiation and maintenance during organ of Corti development.
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Neurog1 and Neurog2 have unique and redundant functions in the piriform cortex, controlling the timing of differentiation of neurons
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ESC expressing Neurogenin1 begin to withdraw from cycle and form precursors that differentiate exclusively into neurons.
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Netrin-1 serves as an attractive guidance cue for Neurog1-induced cells and that this effect is likely mediated by DCC receptor expressed in the growth cones of neurons.
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Neurog1/2 together coordinate development of the olfactory system, which depends on tissue interactions between the olfactory bulb and epithelium.
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A noncoding RNA transcribed from an enhancer element positively regulates transcription at the Neurog1 locus.
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the formation of cranial ganglia along the anterior-posterior axis is dependent on the dynamic spatiotemporal activities of Neurog1 and/or Neurog2 in both neural crest and epibranchial placode.
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Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival.
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Neural zinc finger (NZF)-3 works downstream of Neurog1 and plays a crucial role together with Neurog1 in neuronal differentiation.
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Our data suggest functional Neurog1-Pax6 cross-talk in the activation of downstream targets in early cerebellar development
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This study provides the first overview of the spatiotemporal fate map of Neurogenin1 lineages in the CNS.
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Neurog1 expression in the ventral neural tube is mediated by a distinct enhancer and preferentially marks ventral interneuron lineages.
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Ngn1 is a component of the bHLH factor code regulating cell type specification in the cerebellar cortex.
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genetic analysis has identified Ngn1 as a gene required in basal progenitors to activate an OSN differentiation program, and force dividing progenitors out of the cell exit.
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neurogenin1 regulates neuroD2 expression during mouse brain development
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Sequential phases of cortical specification involve ngn1-dependent and -independent pathways.