anti-Neurogranin (NRGN) Antibodies

Human Neurogranin (NRGN) interaction partners

1. The dynamics of calmodulin interactions with neurogranin and Ca(2+) /CAMKII alpha proteins has been reported.

2. Plasma neurogranin did not correlate with stroke severity.

3. Study observed an association of rs12807809 with schizophrenia in a South Indian population. This study contributes toward the establishment of neurogranin as a susceptibility gene for schizophrenia South Indian Population.

4. associations of neuromodulin and neurogranin to Alzheimer's disease

5. The results of this results showed that increased CSF neurogranin levels in Alzheimer Disease.

6. Polymorphisms in NRGN are associated with schizophrenia, major depressive disorder and bipolar disorder in the Han Chinese population.

7. Neurogranin and YKL-40 are promising AD biomarkers, independent of and complementary to the established core Alzheimer's disease (AD) biomarkers, reflecting additional pathological changes in the course of AD

8. These results confirm an increase in CSF Ng concentration in patients with AD as previously reported and show that this is specific to AD and not seen in a range of other neurodegenerative diseases.

9. This report provides evidence to support larger and controlled traumatic brain injury clinical studies for NRGN validation and prediction of outcomes.

10. Within-person levels of NGRN increased in cognitively normal participants but not in patients with later stage mild cognitive impairment or Alzhiemer's disease; NGRN may reflect presymptomatic synaptic dysfunction or loss.

11. Cerebrospinal fluid neurogranin was increased in patients with Alzheimer's dementia, progressive mild cognitive impairment (MCI) and stable MCI compared with controls, and in Alzheimer's dementia and progressive MCI compared with stable MCI.

12. neurogranin binds to alpha-synuclein in the human cortex, and this interaction decreases in Parkinson's disease along with the phosphorylation of neurogranin, a molecular process thought to be involved in learning and memory

13. These findings help to clarify underlying NRGN mediated pathophysiological mechanisms involving cortical-subcortical brain networks in schizophrenia.

14. Data indicate that neurogranin makes contacts with both the N- and C-domains of calmodulin that functionally leads to altered calcium binding kinetics.

15. NRGN risk variants contribute to subtle changes in neural functioning and anatomy.

16. Our results support an association between the NRGN gene and schizophrenia and a hypothesis that the NRGN gene may mediate the risk associated with schizophrenia via intellectual dysfunction.

17. The influence of NRGN genotype on the neural correlates of memory encoding and retrieval is manifest in the cingulate cortex and is involved in hippocampal formation.

18. single nucleotide polymorphism located upstream of the neurogranin (NRGN) gene has been identified as a risk variant for schizophrenia.

19. This study demonistrated that multiple rare mutations in schizophrenia, and provides genetic clues that indicate the involvement of NRGN in this disorder.

20. This study provides further evidence of the association of the NRGN gene with schizophrenia.

Mouse (Murine) Neurogranin (NRGN) interaction partners

1. Myeloid SIRT1 knockout (KO) mice exhibited higher food intake, weight gain, and lower expression of anorexigenic proopiomelanocortin in the arcuate nucleus than WT mice. In particular, KO mice had lower ventromedial hypothalamus (VMH)-specific neurogranin expression.

2. The findings of this study specifically suggest that accumbal Ng plays an essential role in the counterbalance between NMDAR and mGluR5 signaling.

3. The results of this study indicated that elevated neurogranin function within the PFC can enhance local plasticity and increase the rate of extinction learning across different behavioral tasks.

4. Neurogranin knockout mice are hyperactive and socially withdrawn.

5. Ng expression in olfactory bulb is restricted to developmental stages suggesting activity-dependent regulation in a time window critical for glomerular circuit development, suggesting a role for Ng in maturation and dendritic remodeling of tufted cells.

6. findings suggest that mobilization of CaM and Ng to stimulated dendritic spines may enhance synaptic efficacy by increasing and prolonging the Ca2+ transients and activation of Ca2+/CaM-dependent enzymes.

7. We propose that the differential regulation of multiple sense and novel overlapping natural antisense transcripts at the Nrgn and Camk2n1 loci will increase the diversity of posttranscriptional regulation

8. Results provide a new specific neurochemical marker to identify a subpopulation of olfactory granule cells and suggest possible functional implications for neurogranin in olfactory bulb plasticity mechanisms.

9. Data show that Ng displays a strong nuclear localization when expressed in cell lines and hippocampal neurons.

10. Attenuation of protein kinase C and cAMP-dependent protein kinase signal transduction in the neurogranin knockout mouse

11. Neurogranin expression in the cerebellum by brush cells, which are excitatory, shows remarkable cell type- and species-specific expression patterns of a postsynaptic protein mediating calcium signaling mechanisms.

12. calcium dynamics are altered in cortical neurons lacking the calmodulin-binding protein RC3

13. NMDA induced a rapid and transient phosphorylation and oxidation of neurogranin in mouse hippocampal slices

14. NG is expressed by principal cells in different neocortical layers and in the hippocampus by granule cells of the dentate gyrus and pyramidal neurons of CA1-CA3.

15. Results suggest that neurogranin oxidation plays a significant role in intracellular calcium homeostasis, essential for the activated signaling networks in learning and memory.

16. Ng may promote a high [Ca2+]i by a "mass-action" mechanism; namely, the higher the Ng concentration, the more Ng-CaM complexes will be formed.

17. These results suggest that neurogranin protein may be involved in the development of cerebral hypoxic preconditioning.

18. Data suggest that parasagittal stripes of Purkinje cells express neurogranin, possibly from as early as embryonic day (E) 13 and definitively from E15, in a pattern that persists up to postnatal day 20.

19. Neurogranin(Ng) gates neuronal signaling reactions involved in learning and memory. During environmental enrichment, these Ng-regulated reactions are also critical for enhancement of synaptic plasticity and cognitive functions.

20. Recombinant mNg promotes SNP-induced cell death in human cells through an amplification of calcium-mediated signaling, which requires the interaction between CaM and IQ motif of Ng.

Cow (Bovine) Neurogranin (NRGN) interaction partners

1. interaction of Ca(2+)-free calmodulin (apoCaM) with the IQ motif corresponding to the calmodulin-binding domain of neurogranin has been studied by nuclear magnetic resonance (NMR) methods