anti-Neurogranin (NRGN) Antibodies

Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. Additionally we are shipping Neurogranin Proteins (11) and Neurogranin Kits (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NRGN 4900 Q92686
NRGN 64011 P60761
NRGN 64356 Q04940
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Top anti-Neurogranin Antibodies at

Showing 10 out of 64 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated IHC, ELISA, WB Antibody (0.1µg/ml) staining of Mouse Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Antibody (2µg/ml) staining of Human Cerebellum (A) and Rat Brain (B) lysates (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence 100 μg 6 to 7 Days
Cow Rabbit Un-conjugated WB WB Suggested Anti-Nrgn Antibody Titration: 1.0 ug/ml Positive Control: Rat Brain 100 μL 2 to 3 Days
Human Goat Un-conjugated ELISA, WB 0.1 mg 2 to 3 Days
Cow Goat Un-conjugated ELISA, IHC, IHC (p), WB Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-NRGN / Neurogranin antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml. 50 μg 11 to 14 Days
Cow Goat Un-conjugated EIA, IHC (p), WB Antibody (3.8µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Antibody (0.1µg/ml) staining of Mouse Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg 6 to 8 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-Neurogranin Polyclonal Antibody, Unconjugated(ABIN1387517) 1:200, followed by conjugation to the secondary antibody and DAB. 100 μL 3 to 7 Days
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cells, using NRGN antibody. 100 μL 11 to 13 Days
Human Goat Biotin ELISA, WB   100 μg 6 to 7 Days
Human Goat Un-conjugated IHC (p), ELISA, WB 50 μg 12 to 14 Days
Human Goat Un-conjugated ELISA, IHC (p), WB NRGN polyclonal antibody  (0.1 ug/mL) staining of mouse brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. NRGN polyclonal antibody  (3.8 ug/mL) staining of paraffin embedded human cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 100 μg 11 to 12 Days

More Antibodies against Neurogranin Interaction Partners

Human Neurogranin (NRGN) interaction partners

  1. Although the 3 assays target different epitopes on neurogranin and have different calibrators, the high correlations and the similar group differences suggest that the different forms of neurogranin in CSF carry similar diagnostic information

  2. These data support that CSF Ng is increased specifically in Alzheimer disease, that high CSF Ng concentrations likely reflect synaptic dysfunction and that CSF Ng is associated with beta-amyloid plaque pathology.

  3. This study, cross-sectional analysis showed that high CSF Ng was significantly associated with lower memory scores in pooled participants with NC and MCI.

  4. The dynamics of calmodulin interactions with neurogranin and Ca(2+) /CAMKII alpha proteins has been reported.

  5. Plasma neurogranin did not correlate with stroke severity.

  6. Study observed an association of rs12807809 with schizophrenia in a South Indian population. This study contributes toward the establishment of neurogranin as a susceptibility gene for schizophrenia South Indian Population.

  7. associations of neuromodulin and neurogranin to Alzheimer's disease

  8. The results of this results showed that increased CSF neurogranin levels in Alzheimer Disease.

  9. Polymorphisms in NRGN are associated with schizophrenia, major depressive disorder and bipolar disorder in the Han Chinese population.

  10. Neurogranin and YKL-40 are promising AD biomarkers, independent of and complementary to the established core Alzheimer's disease (AD) biomarkers, reflecting additional pathological changes in the course of AD

  11. These results confirm an increase in CSF Ng concentration in patients with AD as previously reported and show that this is specific to AD and not seen in a range of other neurodegenerative diseases.

  12. This report provides evidence to support larger and controlled traumatic brain injury clinical studies for NRGN validation and prediction of outcomes.

  13. Within-person levels of NGRN increased in cognitively normal participants but not in patients with later stage mild cognitive impairment or Alzhiemer's disease; NGRN may reflect presymptomatic synaptic dysfunction or loss.

  14. Cerebrospinal fluid neurogranin was increased in patients with Alzheimer's dementia, progressive mild cognitive impairment (MCI) and stable MCI compared with controls, and in Alzheimer's dementia and progressive MCI compared with stable MCI.

  15. neurogranin binds to alpha-synuclein in the human cortex, and this interaction decreases in Parkinson's disease along with the phosphorylation of neurogranin, a molecular process thought to be involved in learning and memory

  16. These findings help to clarify underlying NRGN mediated pathophysiological mechanisms involving cortical-subcortical brain networks in schizophrenia.

  17. Data indicate that neurogranin makes contacts with both the N- and C-domains of calmodulin that functionally leads to altered calcium binding kinetics.

  18. NRGN risk variants contribute to subtle changes in neural functioning and anatomy.

  19. Our results support an association between the NRGN gene and schizophrenia and a hypothesis that the NRGN gene may mediate the risk associated with schizophrenia via intellectual dysfunction.

  20. The influence of NRGN genotype on the neural correlates of memory encoding and retrieval is manifest in the cingulate cortex and is involved in hippocampal formation.

Mouse (Murine) Neurogranin (NRGN) interaction partners

  1. Myeloid SIRT1 knockout (KO) mice exhibited higher food intake, weight gain, and lower expression of anorexigenic proopiomelanocortin in the arcuate nucleus than WT mice. In particular, KO mice had lower ventromedial hypothalamus (VMH)-specific neurogranin expression.

  2. The findings of this study specifically suggest that accumbal Ng plays an essential role in the counterbalance between NMDAR and mGluR5 signaling.

  3. The results of this study indicated that elevated neurogranin function within the PFC can enhance local plasticity and increase the rate of extinction learning across different behavioral tasks.

  4. Neurogranin knockout mice are hyperactive and socially withdrawn.

  5. Ng expression in olfactory bulb is restricted to developmental stages suggesting activity-dependent regulation in a time window critical for glomerular circuit development, suggesting a role for Ng in maturation and dendritic remodeling of tufted cells.

  6. findings suggest that mobilization of CaM and Ng to stimulated dendritic spines may enhance synaptic efficacy by increasing and prolonging the Ca2+ transients and activation of Ca2+/CaM-dependent enzymes.

  7. We propose that the differential regulation of multiple sense and novel overlapping natural antisense transcripts at the Nrgn and Camk2n1 loci will increase the diversity of posttranscriptional regulation

  8. Results provide a new specific neurochemical marker to identify a subpopulation of olfactory granule cells and suggest possible functional implications for neurogranin in olfactory bulb plasticity mechanisms.

  9. Data show that Ng displays a strong nuclear localization when expressed in cell lines and hippocampal neurons.

  10. Attenuation of protein kinase C and cAMP-dependent protein kinase signal transduction in the neurogranin knockout mouse

  11. Neurogranin expression in the cerebellum by brush cells, which are excitatory, shows remarkable cell type- and species-specific expression patterns of a postsynaptic protein mediating calcium signaling mechanisms.

  12. calcium dynamics are altered in cortical neurons lacking the calmodulin-binding protein RC3

  13. NMDA induced a rapid and transient phosphorylation and oxidation of neurogranin in mouse hippocampal slices

  14. NG is expressed by principal cells in different neocortical layers and in the hippocampus by granule cells of the dentate gyrus and pyramidal neurons of CA1-CA3.

  15. Results suggest that neurogranin oxidation plays a significant role in intracellular calcium homeostasis, essential for the activated signaling networks in learning and memory.

  16. Ng may promote a high [Ca2+]i by a "mass-action" mechanism; namely, the higher the Ng concentration, the more Ng-CaM complexes will be formed.

  17. These results suggest that neurogranin protein may be involved in the development of cerebral hypoxic preconditioning.

  18. Data suggest that parasagittal stripes of Purkinje cells express neurogranin, possibly from as early as embryonic day (E) 13 and definitively from E15, in a pattern that persists up to postnatal day 20.

  19. Neurogranin(Ng) gates neuronal signaling reactions involved in learning and memory. During environmental enrichment, these Ng-regulated reactions are also critical for enhancement of synaptic plasticity and cognitive functions.

  20. Recombinant mNg promotes SNP-induced cell death in human cells through an amplification of calcium-mediated signaling, which requires the interaction between CaM and IQ motif of Ng.

Cow (Bovine) Neurogranin (NRGN) interaction partners

  1. interaction of Ca(2+)-free calmodulin (apoCaM) with the IQ motif corresponding to the calmodulin-binding domain of neurogranin has been studied by nuclear magnetic resonance (NMR) methods

Neurogranin (NRGN) Antigen Profile

Protein Summary

Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.

Gene names and symbols associated with anti-Neurogranin (NRGN) Antibodies

  • neurogranin (NRGN) antibody
  • neurogranin (Nrgn) antibody
  • neurogranin (protein kinase C substrate, RC3) b (nrgnb) antibody
  • 0710001B06Rik antibody
  • AI838505 antibody
  • hng antibody
  • NG antibody
  • NG/RC3 antibody
  • Pss1 antibody
  • R75334 antibody
  • RC3 antibody
  • zgc:158686 antibody

Protein level used designations for anti-Neurogranin (NRGN) Antibodies

calmodulin-binding protein , neurogranin , ng , protein kinase C substrate , neurogranin (protein kinase C substrate, RC3) , postsynaptic spine 1 , protein kinase C substrate 7.5 kDa protein , B-50 immunoreactive C-kinase substrate , BICKS , NG , p17 , protein kinase C substrate, RC3 , neurogranin (protein kinase C substrate, RC3) b , spa17

4900 Homo sapiens
64011 Mus musculus
64356 Rattus norvegicus
616955 Bos taurus
479401 Canis lupus familiaris
100722735 Cavia porcellus
791178 Danio rerio
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