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Modulates arousal and anxiety.
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A SNP within the neuropeptide s gene is associated with decreased bioactivity.
NPS is able to stimulate human monocyte chemotaxis and that this effect is entirely due to selective NPSR (show NPSR1 ELISA Kits) activation.
The available information regarding NPS and its receptor and the biological actions modulated by the NPS-NPSR (show NPSR1 ELISA Kits) system, is summarized.
NPS-NPSR1 (show NPSR1 ELISA Kits) signaling is likely involved in anxiety
NPS has a novel role in the stimulation of the hypothalamo-pituitary-adrenal axis
the C-terminal region of neuropeptide S maintains importance for in vivo activity
the key residues of NPS involved in NPSR (show NPSR1 ELISA Kits) activation and suggest a molecular basis for the functional effects of the N107I mutation and for its putative pathophysiological link with asthma
Because remodeling of airway epithelium is a feature of chronic asthma, the up-regulation of MMP10 (show MMP10 ELISA Kits) and TIMP3 (show TIMP3 ELISA Kits) by NPS-NPSR1 (show NPSR1 ELISA Kits) signaling may be of relevance in the pathogenesis of asthma.
NPS acts as a novel modulator of arousal and anxiety-related behaviours by promoting a unique pattern of effects: stimulation associated with anxiolysis.
Study showed that the actions of neuropeptide S influenced the excitability of dorsal raphe and laterodorsal tegmentum neurons, which could play a role in the anxiolytic and arousal-promoting effects of this peptide.
NPS-/- mice display significant deficits in exploratory activity, long-term memory and arousal.
Findings demonstrate that neuropeptide S, via selective activation of the neurons bearing neuropeptide S receptor (show NPSR1 ELISA Kits) in the subiculum complex, ameliorates olfactory spatial memory impairment induced by scopolamine and MK801 in mice.
these results indicate that NPS-NPSR system may regulate locomotion together with the CRF1 system in SN.
Study demonstrated that NPS produces anti-aggressive effects in mice through the selective activation of NPSR (show NPSR1 ELISA Kits) and that the endogenous NPS/NPSR (show NPSR1 ELISA Kits) system can exert a role in the control of aggressiveness levels under the present experimental conditions
These data provide evidence for a direct interaction between the corticotropin-releasing factor (show CRH ELISA Kits) and the NPS system and thereby extend previous observations of NPS-modulated stress responsiveness towards a mechanistic level.
Neuropeptide S knock-out mice display deficits in inhibitory avoidance memory indicating involvement in central noradrenergic systems.
Results describe the neuroanatomical, molecular, and functional aspects of neuropeptide S-producing neurons in the mouse brain.
These data demonstrate that the distribution pattern of the central neuropeptide S system is only partially conserved between mice and rats.
results demonstrate that neuropeptide S and NPSR1 (show NPSR1 ELISA Kits) regulate respiratory function through a central nervous system-mediated pathway
Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity).
, neuropeptide S