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Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. Additionally we are shipping NTSR1 Antibodies (85) and NTSR1 Kits (12) and many more products for this protein.
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Data demonstrate that the NTR1 can modulate the methamphetamine-induced striatal neuronal apoptosis independent of body temperature regulation. Possible mechanisms of NTR1 modulating methamphetamine-induced apoptosis include the regulation of dopamine and glutamate (show GRIN1 Proteins) neurotransmission in the striatum.
The roles of neurotensin and its receptor NTR-1 on sperm capacitation and acrosome reaction in mice are reported.
sleep traits and a relationship between Ntsr1 and anxiety and despair behaviors in knockout mice
Data show that NTS1 (show NTS Proteins)(-/-) mouse is an animal model of schizophrenia, particularly for the dysfunction of the prefrontal cortex.
Ntsr1 knockout mice showed a higher freezing rate than wild type mice at both first and second exposures under the condition where a relatively weak unconditioned stimulus (footshock)
Ntsr1 receptor subtype is necessary for normal dopaminergic function.
These findings support the role for Ntsr1 in the mediation of the metabolic effect of xenin (show COPA Proteins) as well as neurotensin (show NTS Proteins).
Neurotensin (show NTS Proteins) type 1 receptor does not play a role in NT-induced analgesia, but that it is clearly implicated in thermal and feeding regulation, weight control, and NT-induced hypolocomotion.
constant activation of NT1 receptor generates an oncogenic regulation
NT and NTR1 are part of network activated after mucosal injuries, and NT stimulates epithelial restitution, at least in part, through a COX-2 dependent pathway.
Heterodimerization of the kappa opioid receptor (show OPRK1 Proteins) and neurotensin receptor 1 contributes to a novel beta-arrestin-2 (show ARRB2 Proteins)-signaling pathway.
Silencing of miR-133alpha or overexpression of aftiphilin attenuated NTR1 trafficking to plasma membrane in human colonocytes.
Neurotensin (show NTS Proteins) receptor-targeted oncolytic adenovirus co-expressing decorin (show DCN Proteins) and Wnt (show WNT2 Proteins) antagonist useful for systemic treatment of NTR-overexpressing pancreatic cancer.
high expression of NTSR1 is found in clinical NETs and promoter methylation is an important mechanism controlling the differential expression of NTSR1 and silencing of NTSR2 (show NTSR2 Proteins) in NET cells
The presence of F358(7.42) causes the conserved W321(6.48) to adopt side chain orientation parallel to the lipid bilayer sealing the collapsed Na(+) ion pocket and linking the agonist with residues in the lower receptor part implicated in GPCR activation.
This study indicated that NTR1 may play an important role in tumor progression of gastric cancer
High expression levels of NTS (show NTS Proteins) and NTSR1 predict a poor prognosis in glioma patients.
the NTR1 (show TFIP11 Proteins)-HIF-1alpha (show HIF1A Proteins)-VEGFalpha axis has a role in intestinal angiogenic responses and in the pathophysiology of colitis and inflammatory bowel disease
NTS (show NTS Proteins)/NTSR1 complex enhances breast tumor aggressiveness via EGFR (show EGFR Proteins)/HER2 (show ERBB2 Proteins)/HER3 (show ERBB3 Proteins) pathway.
Neurotensin (show NTS Proteins) and its receptor NTSR1 causes EGFR (show EGFR Proteins), HER2 (show ERBB2 Proteins) and HER3 (show ERBB3 Proteins) over-expression and their autocrine/paracrine activation in lung adenocarcinomas, confirming responsiveness to erlotinib.
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion.
neurotensin receptor type 1
, neurotensin receptor 1 (high affinity)
, neurotensin receptor type 1-like
, high-affinity levocabastine-insensitive neurotensin receptor