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The protein encoded by NTM is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters.
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NTM is not a susceptibility gene for autism spectrum disorders.
Both the AFF3 and NTM triglyceride associations were replicated among Multi-ethnic Study of Atherosclerosis study participants (P = 1.00 x 10(-7) and 8.00 x 10(-5), respectively).
The generation and cardiac phenotype of single and double heterozygous gene-targeted OPCML (show OPCML Proteins) and Neurotrimin knockout mice.
A translocation breaks intron 1 of a splicing isoform of Neurotrimin at 11q25 in a family with intracranial and thoracic aortic aneurysm.
A quantitative analysis of central corneal thickness and a subsequent analysis of primary open-angle glaucoma (POAG), SNPs in two cell adhesion molecules, NTM and CNTNAP4 (show CNTNAP4 Proteins), were identified and may increase POAG susceptibility in a subset of cases.
The finding of this study provided evidence that NTM at 11q25 chromosome regions affecting IQ.
Human neurotrimin is expressed on the surface of CHO (show COL11A1 Proteins) cells and could strengthen their aggregation.
NTM shows close linkage to OPCML (show OPCML Proteins) on chromosome 11q25.
This study demonstrated that in neurotrimin knockout mice showed a deficit in emotional learning in the active avoidance task and decreased sensitivity to the locomotor stimulating effect of amphetamine.
This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene.
IgLON family member 2
, protein CEPU-1
, CEPU-Se alpha 1 isoform
, CEPU-Se alpha 2 isoform
, IgLON family protein
, neural secreted glycoprotein