anti-Neutrophil Cytosolic Factor 2 (NCF2) Antibodies

NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. Additionally we are shipping NCF2 Proteins (12) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NCF2 4688 P19878
NCF2 17970 O70145
NCF2 364018 A7E3N2
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Top anti-NCF2 Antibodies at antibodies-online.com

Showing 10 out of 75 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-NCF2 Antibody Titration: 1.0 ug/ml Positive Control: MCF7 Whole Cell 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of THP1  using NCF2 antibody. The lane on the left is treated with the antigen-specific peptide. Western blot analysis of NCF2 expression in various lysates 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of Phospho-NCF2(Thr223) in lysates of THP-1, using Phospho-NCF2(Thr223) Antibody(ABIN6267895). 100 μL 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Porcine Spleen lysate; Primary Ab: 5µg/ml Rabbit Anti-Human NCF2 Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg 15 to 18 Days
$314.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Spleen, Neutrophils (formalin-fixed, paraffin-embedded) stained with NCF2 antibody ABIN305776 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-NCF2 / p67phox antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of NCF2 in lysates of THP-1, using NCF2 Antibody(ABIN6268311). 100 μL 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Mouse Spleen lysate; Primary Ab: 2µg/ml Rabbit Anti-Mouse NCF2 Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg 13 to 16 Days
$324.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IP, WB Immunohistochemistry of paraffin-embedded mouse heart using NCF2 antibody at dilution of 1:100 (400x lens). 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated IC, IF, IP, IHC, WB Immunofluorescent analysis of p67 phox staining in Hela cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibo Immunohistochemical analysis of p67 phox staining in mouse heart formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with th 200 μL 13 to 14 Days
$487.50
Details

Top referenced anti-NCF2 Antibodies

  1. Human Polyclonal NCF2 Primary Antibody for IF, IHC - ABIN6714586 : Wang, Yang, Han, Li, Jiang, Tian, Du, Li: NADPH oxidases mediate a cellular "memory" of angiotensin II stress in hypertensive cardiac hypertrophy. in Free radical biology & medicine 2015 (PubMed)

  2. Human Polyclonal NCF2 Primary Antibody for ELISA, IHC - ABIN6263535 : Li, Meng, Zhang, Wang, Yang, Niu, Cui, Wang, Liu, Rao: Testosterone improves erectile function through inhibition of reactive oxygen species generation in castrated rats. in PeerJ 2016 (PubMed)

  3. Human Polyclonal NCF2 Primary Antibody for ICC, IF - ABIN4343179 : Lomnytska, Becker, Bodin, Olsson, Hellman, Hellström, Mints, Hellman, Auer, Andersson: Differential expression of ANXA6, HSP27, PRDX2, NCF2, and TPM4 during uterine cervix carcinogenesis: diagnostic and prognostic value. in British journal of cancer 2011 (PubMed)

More Antibodies against NCF2 Interaction Partners

Pig (Porcine) Neutrophil Cytosolic Factor 2 (NCF2) interaction partners

  1. analysis of NCF2, BCKDHB and BCKDHA in pig

Human Neutrophil Cytosolic Factor 2 (NCF2) interaction partners

  1. Results show that NCF2 expression is highly upregulated in gastric cancer (GC) tumors. However, its mRNA is targeted by miR-532 and its expression repressed. More importantly, NCF2 can in turn upregulate LINC01410 expression via NF-kappaB in GC.

  2. We analyzed the clinical and laboratory findings of CGD with mutations in the NCF2 gene from amongst our cohort of CGD patients. A homozygous mutation (c.835_836delAC, p.T279fsX294), a deletion in NCF2 gene was found in two cases. In the third case, two heterozygous mutations were detected, IVS13-2A>T on one allele and c.1099C>T (p.) on the other allele.

  3. All investigated patients presented the same mutation (c.257 + 2T > C) in NCF2 gene. We show that this mutation is responsible for a drastic decrease of p67phox mRNA and leads to the skipping of exon 3 detected in the low amount of residual mRNA.

  4. Phosphoinositol 3-phosphate regulates reactive oxygen species production by maintaining p40phox and p67phox at the phagosomal membrane.

  5. TLR4- and TLR2-induced IRAK-ERK pathway cross-talks with p67phox-Nox-2 for reactive oxygen species generation, thus regulating IL-1beta transcription and processing in monocytic cells.

  6. Skeletal muscle protein expression of the NADPH oxidase subunits p22(phox), p47(phox), and p67(phox) was increased in obese relative to lean subjects, where p22(phox) and p67(phox) expression was attenuated by exercise training in obese subjects.

  7. A novel homozygous mutation in NCF2.

  8. results reveal an essential role for the Cys-Gly-Cys triad in Nox2 in binding p67(phox), seconded by an additional binding region, comprising residues C terminal to Cys-Gly-Cys. The 2 regions interact with distinct partner sites in p67(phox).

  9. This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4/VAV1/RAC1 NADPH oxidase complex.

  10. Data indicate that arachidonic acid induces the direct interaction of Rac-GTP-bound p67(phox) with the C-terminal cytosolic region of phagocyte NADPH oxidase Nox2.

  11. Four novel mutations in the NCF1, NCF2, and CYBB genees have been identified in chronic granulomatous disease patients in Morocco.

  12. Results not only establish allelic heterogeneity within NCF2 associated with SLE, but also emphasize the utility of multi-ethnic cohorts to identify predisposing variants explaining additional phenotypic variance of complex diseases like SLE.

  13. NCF2 in Asian populations shows a pattern of diversity characterized by a differentiated haplotype structure.

  14. Results provide insight into the redox-sensitive signaling mechanism that mediates cell survival involving p53 and its novel target NCF2/p67phox.

  15. Case Report: report defects in NCF-2, teh gene encoding p67-phox, in four cases of chronic granulomatous disease.

  16. Eight novel mutations in CYBB and NCF2 genes were identified in patients with chronic granulomatous disease.

  17. This variant reduced binding of the NCF2 gene product p67(phox) to RAC2. This study found a novel genetic association of RAC2 with Crohn's disease (CD) and replicated the previously reported association of NCF4 with ileal CD.

  18. NCF2 is strongly associated with increased risk of childhood- and adult-onset systemic lupus erythematosus through a single nonsynonymous coding mutation (H389Q) in exon 12.

  19. p67(phox) has a critical role to support for reactive oxygen species production on the level of individual phagosomes.

  20. Association analysis identified five SLE susceptibility genes reaching genome-wide levels of significance : NCF2 ,IKZF1 ,IRF8 ,IFIH1 , and TYK2

Mouse (Murine) Neutrophil Cytosolic Factor 2 (NCF2) interaction partners

  1. we found that ROS formation and expression of p47(phox) and p67(phox), subunits of NADPH oxidase, were increased in AppTg mice but attenuated in AppTg/Cebpd(-/-) mice. Cebpd can up-regulate p47(phox) and p67(phox) transcription via a direct binding on their promoters, which results in an increase in intracellular oxidative stress

  2. Just as patients with chronic granulomatous disease who lack NADPH oxidase rarely develop SLE, NCF-2-null mice on a nonautoimmune background were susceptible to a chronic granulomatous disease-like opportunistic infection but did not develop lupus. In contrast, on a lupus-prone background, even haploinsufficiency of NCF-2 accelerated the development of full-blown lupus disease.

  3. p67(phox) binds to phosphoPrdx6 and inhibits its PLA2 activity, an interaction that could function to terminate the PLA2-mediated NOX2 activation signal.

  4. The results of this study suggested that repeated stress promotes depressive behavior through the upregulation of NADPH oxidasesubunit (67kDa) and the resultant metabolic oxidative stress.

  5. Data suggest that a cytosolic source of reactive oxygen species, probably p67(phox) subunit of cardiac NADPH oxidase 2 (NOX2), may contribute to the hypertrophic phenotype in glucose transporter 4 gene (GLUT4-/-) mice.

  6. This report evaluates neutrophil cytosolic factor 2 (Ncf2) as a candidate Salmonella susceptibility gene for Ity3.

  7. This study demonstrates the involvement of ROS from NADPH oxidase in mediating paraquat cytotoxicity in BV-2 microglial cells and this process is mediated through PKCdelta- and ERK-dependent pathways.

  8. binding of the ternary complex to phagosomes can be temporally regulated by switching between adaptor proteins that have PX domains with distinct lipid-binding specificities

NCF2 Antigen Profile

Protein Summary

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with NCF2

  • neutrophil cytosolic factor 2 (NCF2) antibody
  • neutrophil cytosolic factor 2 L homeolog (ncf2.L) antibody
  • neutrophil cytosolic factor 2 (ncf2) antibody
  • neutrophil cytosolic factor 2 (p67phox) antibody
  • neutrophil cytosol factor 2 (VDBG_06643) antibody
  • hypothetical protein (PGTG_05816) antibody
  • neutrophil cytosolic factor 2 (LOC100136240) antibody
  • neutrophil cytosolic factor 2 (Ncf2) antibody
  • MGC81877 antibody
  • Ncf-2 antibody
  • NOXA2 antibody
  • P67-PHOX antibody
  • P67PHOX antibody
  • zgc:158405 antibody

Protein level used designations for NCF2

neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) , neutrophil cytosolic factor 2 , neutrophil cytosol factor 2 , predicted neutrophil cytosolic factor 2 , p67phox , p67-phox , NADPH oxidase cytosolic protein p67phox , NADPH oxidase cytosolic protein , 67 kDa neutrophil oxidase factor , NADPH oxidase activator 2 , chronic granulomatous disease, autosomal 2 , neutrophil NADPH oxidase factor 2 , neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2) , NADPH oxidase subunit (67 kD) , NADPH oxidase subunit (67kDa) , NCF-2

GENE ID SPECIES
424445 Gallus gallus
444487 Xenopus laevis
457573 Pan troglodytes
480036 Canis lupus familiaris
562473 Danio rerio
619224 Ciona intestinalis
619367 Xenopus (Silurana) tropicalis
9537124 Verticillium alfalfae VaMs.102
10531323 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100008802 Oryctolagus cuniculus
100136240 Oncorhynchus mykiss
100142665 Sus scrofa
100174692 Pongo abelii
100270811 Salmo salar
4688 Homo sapiens
17970 Mus musculus
364018 Rattus norvegicus
281346 Bos taurus
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