anti-NPC1 Antibodies
NPC1 encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain.
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anti-NPC1 antibody (Niemann-Pick Disease, Type C1) (AA 34-174) Primary Antibody
anti-NPC1 antibody (Niemann-Pick Disease, Type C1) (AA 34-174) Primary Antibody
anti-NPC1 antibody (Niemann-Pick Disease, Type C1) (AA 591-620) Primary Antibody
anti-NPC1 antibody (Niemann-Pick Disease, Type C1) (C-Term) Primary Antibody
anti-NPC1 antibody (Niemann-Pick Disease, Type C1) (AA 151-250) Primary Antibody
anti-NPC1 antibody (Niemann-Pick Disease, Type C1) Primary Antibody
anti-NPC1 antibody (Niemann-Pick Disease, Type C1) (C-Term) Primary Antibody
anti-NPC1 antibody (Niemann-Pick Disease, Type C1) Primary Antibody
anti-NPC1 antibody (Niemann-Pick Disease, Type C1) (C-Term) Primary Antibody
anti-NPC1 antibody (Niemann-Pick Disease, Type C1) (Internal Region) Primary Antibody
NPC1 Antigen Profile
Protein Summary
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.
Gene names and symbols associated with NPC1
- NPC intracellular cholesterol transporter 1 (NPC1) antibody
- Niemann-Pick disease, type C1 (npc1) antibody
- Niemann-Pick C1 protein (LOC579887) antibody
- NPC intracellular cholesterol transporter 1 (Npc1) antibody
- A430089E03Rik antibody
- C85354 antibody
- Cdig2 antibody
- D18Ertd139e antibody
- D18Ertd723e antibody
- im:7149020 antibody
- lcsd antibody
- nmf164 antibody
- NPC antibody
- spm antibody
- wu:fb53a12 antibody
- wu:fc29a12 antibody
Protein level used designations for NPC1
Niemann-Pick C1 protein , Niemann-Pick type C1 disease protein , Nasopharyngeal carcinoma 1 , Niemann-Pick C1 , Niemann-Pick disease, type C1 , sphingomyelinosis , Niemann-Pick C disease protein
GENE ID | SPECIES |
---|---|
403698 | Canis lupus familiaris |
455338 | Pan troglodytes |
493693 | Felis catus |
553330 | Danio rerio |
579887 | Strongylocentrotus purpuratus |
100008746 | Oryctolagus cuniculus |
18145 | Mus musculus |
4864 | Homo sapiens |
397591 | Sus scrofa |
421076 | Gallus gallus |
266732 | Rattus norvegicus |
100718604 | Cavia porcellus |
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