anti-Niemann-Pick Disease, Type C1 (NPC1) Antibodies

NPC1 encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. Additionally we are shipping NPC1 Proteins (10) and NPC1 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NPC1 18145 O35604
NPC1 4864 O15118
NPC1 266732  
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Top anti-NPC1 Antibodies at antibodies-online.com

Showing 10 out of 83 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chinese Hamster Rabbit Un-conjugated EM, ICC, IF, IHC, IHC (p), WB Detection of human NPC1 in 20 ug of human fibroblast cell lysate using ABIN152916. Brain, Cortex, Neurons and Astrocytes 40x 0.1 mL Log in to see 7 to 9 Days
$485.88
Details
Human Rabbit Un-conjugated IF, IHC (p), WB NPC1 Antibody (Center)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the NPC1 antibody detected the NPC1 protein (arrow). Confocal immunofluorescent analysis of NPC1 Antibody (Center)  with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$430.10
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged NPC1 is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Goat Un-conjugated ELISA, WB ABIN1590132 (0.5 µg/mL) staining of HEK293 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Anti-NPC1 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959667 concentration 5 ug/ml. Anti-NPC1 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959667 concentration 5 ug/ml. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Human Mouse Un-conjugated IF, IHC, IHC (p), IP, WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with NPC1 antibody ABIN462125 followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Human Colon (formalin-fixed, paraffin-embedded) stained with NPC1 antibody ABIN462125 followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$727.83
Details
Mouse Goat Un-conjugated ELISA   100 μg Log in to see 7 to 9 Days
$507.83
Details
Human Mouse Un-conjugated FACS, IHC, ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.19
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB   100 μg Log in to see 15 to 19 Days
$511.06
Details

NPC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-NPC1 Antibodies

  1. Chinese Hamster Polyclonal NPC1 Primary Antibody for EM, ICC - ABIN152916 : Infante, Abi-Mosleh, Radhakrishnan, Dale, Brown, Goldstein: Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. in The Journal of biological chemistry 2008 (PubMed)
    Show all 32 Pubmed References

  2. Human Monoclonal NPC1 Primary Antibody for IHC, ELISA - ABIN1724876 : Morales, Amigo, Balboa, Acuña, Castro, Molina, Miquel, Nervi, Rigotti, Zanlungo: Deficiency of Niemann-Pick C1 protein protects against diet-induced gallstone formation in mice. in Liver international : official journal of the International Association for the Study of the Liver 2010 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal NPC1 Primary Antibody for ELISA, WB - ABIN396466 : Maetzel, Sarkar, Wang, Abi-Mosleh, Xu, Cheng, Gao, Mitalipova, Jaenisch: Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells. in Stem cell reports 2014 (PubMed)

More Antibodies against NPC1 Interaction Partners

Zebrafish Niemann-Pick Disease, Type C1 (NPC1) interaction partners

Rabbit Niemann-Pick Disease, Type C1 (NPC1) interaction partners

Mouse (Murine) Niemann-Pick Disease, Type C1 (NPC1) interaction partners

Human Niemann-Pick Disease, Type C1 (NPC1) interaction partners

NPC1 Antigen Profile

Protein Summary

This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.

Gene names and symbols associated with NPC1

  • NPC intracellular cholesterol transporter 1 (NPC1) antibody
  • Niemann-Pick disease, type C1 (npc1) antibody
  • Niemann-Pick C1 protein (LOC579887) antibody
  • NPC intracellular cholesterol transporter 1 (Npc1) antibody
  • A430089E03Rik antibody
  • C85354 antibody
  • Cdig2 antibody
  • D18Ertd139e antibody
  • D18Ertd723e antibody
  • im:7149020 antibody
  • lcsd antibody
  • nmf164 antibody
  • NPC antibody
  • spm antibody
  • wu:fb53a12 antibody
  • wu:fc29a12 antibody

Protein level used designations for NPC1

Niemann-Pick C1 protein , Niemann-Pick type C1 disease protein , Nasopharyngeal carcinoma 1 , Niemann-Pick C1 , Niemann-Pick disease, type C1 , sphingomyelinosis , Niemann-Pick C disease protein

GENE ID SPECIES
403698 Canis lupus familiaris
455338 Pan troglodytes
493693 Felis catus
553330 Danio rerio
579887 Strongylocentrotus purpuratus
100008746 Oryctolagus cuniculus
18145 Mus musculus
4864 Homo sapiens
397591 Sus scrofa
421076 Gallus gallus
266732 Rattus norvegicus
100718604 Cavia porcellus
Selected quality suppliers for anti-NPC1 (NPC1) Antibodies
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