NSMCE2 Proteins

Protein Summary

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Is not be required for the stability of the complex.The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. Required for sister chromatid cohesion during prometaphase and mitotic progression (By similarity).

Gene names and symbols associated with NSMCE2

• NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase (Nsmce2) antibody
• NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase (NSMCE2) antibody
• NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog (nsmce2.L) antibody
• Smc5-6 complex non-SMC subunit 2 (nse2) antibody

• 1110014D18Rik antibody
• AI661537 antibody
• C8orf36 antibody
• MMS21 antibody
• Non-SMC element 2 antibody
• Show all synonym aliases
• NSE2 antibody
• RGD1305156 antibody
• ZMIZ7 antibody

Protein level used designations for NSMCE2

E3 SUMO-protein ligase NSE2 , MMS21 homolog , non-structural maintenance of chromosomes element 2 homolog , non-SMC element 2 homolog , hMMS21 , methyl methanesulfonate sensitivity gene 21 , zinc finger, MIZ-type containing 7 , non-SMC element 2 homolog (MMS21, S. cerevisiae) , Non-structural maintenance of chromosomes element 2