NSMCE2 Proteins

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination.

Data Quality
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Type
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    Protein
Antigen
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Reactivity
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Application
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Host
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Binding Specificity
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Conjugate
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Protein Type
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Format
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8 Products
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3094191
$6,570.39
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 50 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse (Murine)
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3136789
$6,570.39
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 50 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2727651
$302.50
50 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
ReactivityHuman
Application AP, AA, ELISA, WB
Order details Cat. No. ABIN1313078
$414.29
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
ReactivityXenopus laevis
Application ELISA
Order details Cat. No. ABIN1678295
$2,603.33
1 mg
Plus shipping costs $45.00
Delivery in 60 to 71 Business Days
ReactivityRat (Rattus)
Application ELISA
Order details Cat. No. ABIN1631717
$2,632.67
1 mg
Plus shipping costs $45.00
Delivery in 60 to 71 Business Days
ReactivityCow (Bovine)
Application ELISA
Order details Cat. No. ABIN1626331
$2,634.50
1 mg
Plus shipping costs $45.00
Delivery in 60 to 71 Business Days
ReactivitySchizosaccharomyces pombe
Application ELISA
Order details Cat. No. ABIN1630605
$2,641.83
1 mg
Plus shipping costs $45.00
Delivery in 60 to 71 Business Days
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NSMCE2 Protein Profile

Protein Summary

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Is not be required for the stability of the complex.The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. Required for sister chromatid cohesion during prometaphase and mitotic progression (By similarity).

Gene names and symbols associated with NSMCE2

  • NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase (Nsmce2) antibody
  • NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase (NSMCE2) antibody
  • NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog (nsmce2.L) antibody
  • Smc5-6 complex non-SMC subunit 2 (nse2) antibody
  • 1110014D18Rik antibody
  • AI661537 antibody
  • C8orf36 antibody
  • MMS21 antibody
  • Non-SMC element 2 antibody
  • NSE2 antibody
  • RGD1305156 antibody
  • ZMIZ7 antibody

Protein level used designations for NSMCE2

E3 SUMO-protein ligase NSE2 , MMS21 homolog , non-structural maintenance of chromosomes element 2 homolog , non-SMC element 2 homolog , hMMS21 , methyl methanesulfonate sensitivity gene 21 , zinc finger, MIZ-type containing 7 , non-SMC element 2 homolog (MMS21, S. cerevisiae) , Non-structural maintenance of chromosomes element 2

GENE ID SPECIES
68501 Mus musculus
299957 Rattus norvegicus
286053 Homo sapiens
519974 Bos taurus
379272 Xenopus laevis
100724833 Cavia porcellus
2542312 Schizosaccharomyces pombe 972h-
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