Nuclear Factor kappa B Proteins (NFkB)

NFkB encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. Additionally we are shipping Nuclear Factor kappa B Antibodies (43) and Nuclear Factor kappa B Kits (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NFkB 4790 P19838
NFkB 81736  
Mouse NFkB NFkB 18033 P25799
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Top Nuclear Factor kappa B Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag,HIS-T7 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Rat GST tag,His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Chicken His tag 100 μg Log in to see 15 to 18 Days

NFkB Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

More Proteins for Nuclear Factor kappa B (NFkB) Interaction Partners

Human Nuclear Factor kappa B (NFkB) interaction partners

  1. High NFKB1 expression is associated with Osteoarthritis.

  2. High NFKB1 expression is associated with Invasive Bladder Cancer.

  3. Findings identified eyes absent homolog 4 (EYA4) as a tumor suppressor that disrupts aberrant activation of the nuclear factor kappa B (NF-kappaB)/RAP1 protein signaling pathway and thus orchestrates a physiological impediment to hepatocellular carcinoma (HCC) growth and invasion.

  4. miR-449a functions as a tumor suppressor in NSCLC by targeting the HMGB1-mediated NF-kappaB signaling pathway in NSCLC.

  5. The role of tumor microenvironment, inflammation and NF-kappaB and RET genes expression regulation in the initiation and development of papillary thyroid carcinoma was shown. (Review)

  6. Genetic variability in MUC2, NFKB1 and CD14 may have a role in the evolution of the GCPLs along time and in gastric carcinogenesis.

  7. RSV infection modulates the p53/NF-kappaB balance via a NS1/NS2 - PI3K/Akt pathway

  8. High NFKB expression is associated with metastasis in breast cancer.

  9. HAPLN1 is produced in bone marrow stromal cells from multiple myeloma patients and can activate bortezomib-resistant NF-kappaB.

  10. FLIP-driven immunosuppression is mediated by NF-kappaB.

  11. Results show activation of NF-kappaB immediately after epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). treatment in PC-9 cells capable of acquiring EGFR-TKI resistance; suggest that altruistic survival and NF-kappaB activation might be vital for initiating the acquisition of EGFR-TKI resistance.

  12. The authors found that Notch1 is up-regulated in the wound edge and its expression is dependent on JMJD3 and NF-kappaB in wounded keratinocytes.

  13. Western blotting analyses revealed that the T. gondii ME-49 strain increased the expression of A20 and decreased both ABIN1 expression and NF-kappaB p65 phosphorylation.

  14. These results suggest that Gal-3 expression is closely correlated with HIV-1 expression in latently infected cells through NF-kappaB activation and that it interacts with HIV-1 Tat.

  15. EZH2 activity and expression are impaired by excess S-adenosylhomocysteine in endothelial cells. EZH2 suppression may mediate S-adenosylhomocysteine - induced NFkappaB activation and inflammatory responses.

  16. CFTR silencing promoted the expression of NF-kappaB-p65 and NF-kappaB-p50, and the results of CFTR overexpression were reversed.

  17. The apoptosis was partially dependent upon caspase-8 concomitant with attenuated NF-kappa B survival signal due to stimulus of TNF-alpha. It suggests that PAK4 as target is a switch between caspase-8 apoptosis and NF-kappa B survival signals induced by TNF-alpha in hepatocarcinoma cells.

  18. Hypoxia-induced NKILA expression negatively regulates NF-kappa B to promote retinal pigment epithelium cell death.

  19. Ferritin Heavy Chain (FHC) protein expression inversely correlates with NF-kappaB activation in cancer cell lines.

  20. The results suggest that netrin-1 promotes glioma cell proliferation by activating NF-kappaB signaling via UNC5A.

Pig (Porcine) Nuclear Factor kappa B (NFkB) interaction partners

  1. Actinobacillus pleuropneumoniae induces alveolar Macrophages to produce proinflammatory cytokines via upregulation of TLR4 and NF-kappaB.

  2. Here, heat shock protein 27 (Hsp27) has been identified as a novel binding partner of NS5A, a protein functioning in classical swine fever virus genome replication. Further findings clearly demonstrate that the inhibition of viral replication by Hsp27 is mediated via the NF-kappaB signaling pathway.

  3. Porcine parvovirus virus infection significantly induced IL-6 expression and this induction depended on NF-kappaB activation and TLR9 signaling pathways in PK-15 cell.

  4. This study showed that porcine epidemic diarrhea virus inhibited NF-kappaB activity and nsp1 was a potent NF-kappaB antagonist for suppression of both interferon and early production of pro-inflammatory cytokines.

  5. inhibition of NF-kappaB increases autophagy via JNK signaling, and promotes steroidogenesis in porcine granulosa cells

  6. SIRT1, p53 and NF-kappaB are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  7. porcine CD74 significantly enhanced the inflammatory response by regulating the NF-kappaB signalling pathway during PCV2 infection, which suggests that porcine CD74 may be implicated in the pathogenesis of PCV2 infection.

  8. These results suggest that trans-10, cis-12-conjugated linoleic acid can modulate TNF-alpha production and NF-kappa B expression by a PPARgamma-dependent pathway in porcine peripheral blood mononuclear cells.

Mouse (Murine) Nuclear Factor kappa B (NFkB) interaction partners

  1. High NFKB1expression is associated with Osteoarthritis.

  2. Reducing NF-kappaB activation attenuates PDLIM2 deficiency-exacerbated inflammation and dyslipidemia in Palmitate -treated primary hepatocytes.

  3. Findings confirm that signalling through MyD88 is the primary driver for Lipopolysaccharide-dependent NF-kappaB translocation to the nucleus. The pattern of NF-kappaB dynamics in TRIF-deficient cells does not, however, directly reflect the kinetics of TNFalpha promoter activation, supporting the concept that TRIF-dependent signalling plays an important role in the transcription of this cytokine.

  4. Chandipura virus infection triggered the activation of signalling pathways mediated by mitogen-activated protein kinases, including p38, JNK 1 and 2, and nuclear factor kappaB.

  5. These findings provide mechanistic insight into how polymorphisms that attenuate NFKB1 expression predispose humans to epithelial cancers, highlighting the pro-tumorigenic activity of STAT1 and identifying targetable vulnerabilities in GC.

  6. Macrophage-derived IL1B/NF-kappaB signaling mediates parenteral nutrition-associated cholestasis in a mouse model.

  7. SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF-kappaB pathway in mouse Kupffer cells.

  8. activation of NF-kappaB pathway is essential for Bacterial lipoprotein tolerance-augmented antimicrobial activity in innate phagocytes and depends primarily on both NOD1 and NOD2.

  9. High host NF-kappaB p50 induces murine glioblastoma tumor.

  10. NF-kappaB is responsible for Morgana dependent metastasis.

  11. study indicates that downregulation of NF-kappaB1 can suppress renal cell carcinoma tumorigenesis by inducing late apoptosis/necrosis

  12. TNF-alpha is involved in cardiac PHLPP1 upregulation during reoxygenation, which is mediated by NF-kappaB transcriptional activity

  13. Nuclear Factor kappa B (NF-kappaB) pathway in the bone marrow (BM) vascular niche is a critical signalling axis that regulates haematopoietic stem cells (HSCs) function.

  14. NF-kappaB and survivin are coordinately up-regulated in GBM patient tumors, and functional inhibition of either protein or BRD4 in in vitro and in vivo models restores sensitivity to EGFR tyrosine kinase inhibitors

  15. NF-kappaB1 phosphorylation is regulated by platelet-activating factor in macrophages.

  16. Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-kappaB signaling suppression.

  17. NF-kappaBmiR15abFGF/VEGFA axis contributes to the impaired angiogenic capacity of bone marrowmesenchymal stem cells in high fat dietfed mice.

  18. ESP of fifth-stage larval Angiostrongylus cantonensis stimulates astrocyte activation and IL-1beta and IL-6 production through NF-kappaB and the Shh signaling pathway.

  19. Tyr42 phosphorylation of RhoA GTPase promotes tumorigenesis through NF-kappaB.

  20. By modulating the translation of IkappaBalpha via the Mnk2-eIF4E pathway, Brd4 provides an additional layer of control for NF-kappaB-dependent inflammatory gene expression and inflammatory response.

Nuclear Factor kappa B (NFkB) Protein Profile

Protein Summary

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Nuclear Factor kappa B Proteins (NFkB)

  • nuclear factor kappa B subunit 1 (NFKB1)
  • nuclear factor kappa B subunit 1 (Nfkb1)
  • nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 (Nfkb1)
  • EBP-1 protein
  • KBF1 protein
  • NF-kappa-B protein
  • NF-kappaB protein
  • NF-kappaB1 protein
  • NF-kB protein
  • NF-KB1 protein
  • NFkappaB protein
  • NFKB-p50 protein
  • NFKB-p105 protein
  • p50 protein
  • p50/p105 protein
  • p105 protein

Protein level used designations for Nuclear Factor kappa B Proteins (NFkB)

DNA binding factor KBF1 , DNA-binding factor KBF1 , NF-kappabeta , nuclear factor NF-kappa-B p105 subunit , nuclear factor NF-kappa-B p50 subunit , nuclear factor kappa-B DNA binding subunit , nuclear factor of kappa light chain gene enhancer in B-cells 1, p105 , nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 , NF-kB p50 subunit , nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) , nuclear factor kappa-B 1 , EBP-1 , NF kappaB1 , NF-kappa-B1 p84/NF-kappa-B1 p98 , NF-kappaB p50 , nuclear factor kappaB p50 , nuclear factor-kappaB p50 , p50 subunit of NF kappaB , p50 subunit of NF-kappaB

4790 Homo sapiens
81736 Rattus norvegicus
396033 Gallus gallus
442859 Canis lupus familiaris
751869 Sus scrofa
18033 Mus musculus
100730075 Cavia porcellus
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