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NFkB encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. Additionally we are shipping Nuclear Factor kappa B Kits (42) and Nuclear Factor kappa B Antibodies (42) and many more products for this protein.
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Data do not support a role for the NFKB1 (show NFKB1 Proteins) and HIF1A (show HIF1A Proteins) polymorphisms in the pathogenesis of bowel disease.
a few seconds of exposure to TNF (show TNF Proteins) is sufficient to activate the NF-kappaB (show NFKB1 Proteins) pathway in HeLa cells and induce apoptotic cell death in both HeLa and Kym-1 cells
HMGB1 (show HMGB1 Proteins) mediates fibroblast activity via RAGE (show AGER Proteins)-MAPK (show MAPK1 Proteins) and NF-kappaB (show NFKB1 Proteins) signaling in keloid scar formation.
NFkappaB1-94ins/ins (show INS Proteins) genotype was associated with the risk of developing colorectal cancer in Egyptian subjects.
miR (show MLXIP Proteins)-146 exerted protective functions might be via up-regulation of Sirt1 (show SIRT1 Proteins) thereby blocking NF-kappaB (show NFKB1 Proteins) and Notch (show NOTCH1 Proteins) pathways.
Data suggest that environmental carcinogen PFOA (perfluorooctanoic acid) stimulates ovarian cancer cell migration, invasion, and MMP2/MMP9 expression by up-regulating ERK/NFkappaB signaling pathway. (MMP = matrix metallopeptidase; NFkappaB = nuclear factor kappa B)
Significantly elevated blood levels of NFkappaB in myelodysplastic syndrome patients.
These data indicate a process of NF-kappaB (show NFKB1 Proteins)-induced miR (show MLXIP Proteins)-506 suppression and JAG1 (show JAG1 Proteins) upregulation upon IL-1beta (show IL1B Proteins) induction.
High Expressions of NFkappaB is associated with degenerative knee osteoarthritis.
Inflammatory factors suppress microRNA-1275 transcription in human adipocytes through NF-kappaB (show NFKB1 Proteins).
Here, heat shock protein 27 (Hsp27) has been identified as a novel binding partner of NS5A, a protein functioning in classical swine fever virus genome replication. Further findings clearly demonstrate that the inhibition of viral replication by Hsp27 is mediated via the NF-kappaB signaling pathway.
Porcine parvovirus virus infection significantly induced IL-6 (show IL6 Proteins) expression and this induction depended on NF-kappaB (show NFKB1 Proteins) activation and TLR9 (show TLR9 Proteins) signaling pathways in PK-15 cell.
This study showed that porcine epidemic diarrhea virus inhibited NF-kappaB (show NFKB1 Proteins) activity and nsp1 was a potent NF-kappaB (show NFKB1 Proteins) antagonist for suppression of both interferon (show IFNA Proteins) and early production of pro-inflammatory cytokines.
inhibition of NF-kappaB (show NFKB1 Proteins) increases autophagy via JNK (show MAPK8 Proteins) signaling, and promotes steroidogenesis in porcine granulosa cells
SIRT1 (show SIRT1 Proteins), p53 (show TP53 Proteins) and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.
porcine CD74 (show CD74 Proteins) significantly enhanced the inflammatory response by regulating the NF-kappaB (show NFKB1 Proteins) signalling pathway during PCV2 infection, which suggests that porcine CD74 (show CD74 Proteins) may be implicated in the pathogenesis of PCV2 infection.
These results suggest that trans-10, cis (show CISH Proteins)-12-conjugated linoleic acid can modulate TNF-alpha (show TNF Proteins) production and NF-kappa B (show NFKB1 Proteins) expression by a PPARgamma (show PPARG Proteins)-dependent pathway in porcine peripheral blood mononuclear cells.
Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-kappaB (show NFKB1 Proteins) signaling suppression.
NF-kappaBmiR15abFGF/VEGFA (show VEGFA Proteins) axis contributes to the impaired angiogenic capacity of bone marrowmesenchymal stem cells in high fat dietfed mice.
ESP of fifth-stage larval Angiostrongylus cantonensis stimulates astrocyte activation and IL-1beta (show IL1B Proteins) and IL-6 (show IL6 Proteins) production through NF-kappaB (show NFKB1 Proteins) and the Shh (show SHH Proteins) signaling pathway.
Tyr42 phosphorylation of RhoA GTPase promotes tumorigenesis through NF-kappaB (show NFKB1 Proteins).
By modulating the translation of IkappaBalpha (show NFKBIA Proteins) via the Mnk2 (show MKNK2 Proteins)-eIF4E (show EIF4E Proteins) pathway, Brd4 (show BRD4 Proteins) provides an additional layer of control for NF-kappaB (show NFKB1 Proteins)-dependent inflammatory gene expression and inflammatory response.
BCA3 (show AKIP1 Proteins) interacts with Rac1 and augments NF-kappaB (show NFKB1 Proteins) signaling in vitro, but has no effect on RANKL (show TNFSF11 Proteins)-induced bone resorption in vivo.
TLR4 (show TLR4 Proteins)-NF-kappaB (show NFKB1 Proteins) signaling pathway was involved in the lipopolysaccharide-induced acute lung injury.
This is the first report demonstrating that NF-kappaB (show NFKB1 Proteins) signaling may play a key role in compensatory lung growth (CLG (show PLEKHG2 Proteins)). Given its pathway is crucial in tissue regeneration of various organs, NF-kappaB (show NFKB1 Proteins) may shed light on identification of molecular triggers or clinically usable key regulators of CLG (show PLEKHG2 Proteins).
Abrogating ClC-3 (show CLCN3 Proteins) blunts lipopolysaccharide-induced Inflammation via blocking the TLR4 (show TLR4 Proteins)/NF-kappaB (show NFKB1 Proteins) pathway.
miR-17 approximately 92 family clusters have a role in iNKT cell ontogenesis via modulation of TGF-beta (show TGFB1 Proteins) signaling
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
DNA binding factor KBF1
, DNA-binding factor KBF1
, nuclear factor NF-kappa-B p105 subunit
, nuclear factor NF-kappa-B p50 subunit
, nuclear factor kappa-B DNA binding subunit
, nuclear factor of kappa light chain gene enhancer in B-cells 1, p105
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
, NF-kB p50 subunit
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
, nuclear factor kappa-B 1
, NF kappaB1
, NF-kappa-B1 p84/NF-kappa-B1 p98
, NF-kappaB p50
, nuclear factor kappaB p50
, nuclear factor-kappaB p50
, p50 subunit of NF kappaB
, p50 subunit of NF-kappaB