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Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Additionally we are shipping and many more products for this protein.
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Human Monoclonal NPAT Primary Antibody for IF, WB - ABIN968484
Zhao, Dynlacht, Imai, Hori, Harlow: Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry. in Genes & development 1998
NPAT links E2F (show E2F1 Antibodies) to the activation of S-phase-specific histone gene transcription.
Data indicate that the CDK2 (show CDK2 Antibodies)/cyclin E (show CCNE1 Antibodies)/p220(NPAT)/HINFP (show HINFP Antibodies)/histone gene signaling pathway at the G1/S phase transition is an essential, nonredundant cell cycle regulatory mechanism that is established early in embryogenesis.
Cpn10 (show HSPE1 Antibodies) has a role in the spatial regulation of NPAT signaling
The conserved C-terminal domain shared by FLASH, YARP, and Mute recognizes the C-terminal sequence of NPAT orthologues, thus acting as a signal targeting proteins to histone locus bodies.
Genetic variants of NPAT-ATM (show ATM Antibodies) and AURKA (show AURKA Antibodies) are associated with an individual early adverse reaction in the gastrointestinal tract of patients with cervical cancer treated with pelvic radiation therapy
NPAT is thus far the first gene implicated in nodular lymphocyte predominant Hodgkin lymphoma predisposition.
NPAT is essential for histone mRNA 3' end processing and recruits CDK9 (show CDK9 Antibodies) to replication-dependent histone genes.
Results characterize the functional signals required for NPAT localization to the cell nucleus.
the ability of p220 (show EIF4G1 Antibodies) to promote S phase is independent of its ability to promote histone H4 transcription and p220 (show EIF4G1 Antibodies) may link cyclin E (show CCNE1 Antibodies)/Cdk2 (show CDK2 Antibodies) to multiple independent downstream functions
OCA-S, the multicomponent Oct-1 (show POU2F1 Antibodies) coactivator, intercts with NPAT.
p220 (show EIF4G1 Antibodies) is an essential downstream component of the cyclin E (show CCNE1 Antibodies)/Cdk2 (show CDK2 Antibodies) signaling pathway and functions to coordinate multiple elements of the G1/S transition.
Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes (By similarity).
, nuclear protein in the AT region
, nuclear protein, ataxia-telangiectasia locus
, protein NPAT-like
, nuclear protein of the ATM locus
, nuclear protein of the ataxia telangiectasia mutated locus