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NVL encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily.
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knockdown of WDR74 leads to significant defects in the pre-rRNA cleavage within the internal transcribed spacer 1, occurring in an early stage of the processing pathway. When the dissociation of WDR74 from the MTR4-containing exonuclease complex was impaired upon expression of mutant NVL2, the same processing defect, with partial migration of WDR74 from the nucleolus towards the nucleoplasm, was observed.
Results indicated that the NVL gene may contain overlapping common genetic risk factors for major depressive disorder and schizophrenia in the Han Chinese population
results suggest that WDR74 is a novel regulatory protein of the MTR4-exsosome complex whose interaction is regulated by NVL2 (show HPCAL4 Proteins) and is involved in ribosome biogenesis
suggest that NVL2 (show HPCAL4 Proteins) is involved in pre-rRNA processing by associating with the nuclear exosome complex and that MPP6 (show MPHOSPH6 Proteins) is required for maintaining the integrity of this rRNA processing complex
these findings suggest that NVL2 (show HPCAL4 Proteins) is essential for telomerase biogenesis and provides an alternative approach for inhibiting telomerase activity in cancer.
NVL2 (show HPCAL4 Proteins) might facilitate the dissociation and recycling of nucleolin (show NCL Proteins), thereby promoting efficient ribosome biogenesis
interaction of NVL2 (show HPCAL4 Proteins) with ribosomal protein L5 (show RPL5 Proteins) is ATP-dependent and likely contributes to the nucleolar translocation of NVL2 (show HPCAL4 Proteins)
Nuclear VCP/p97 (show vcp Proteins)-like protein 2 might regulate the association/dissociation reaction of DOB1 with pre-ribosomal particles by acting as a molecular chaperone (show HSP90AA1 Proteins).
This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin.
nuclear valosin-containing protein-like
, nuclear VCP-like
, nuclear VCP-like protein