Nuclear VCP-Like Proteins (NVL)

NVL encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Additionally we are shipping NVL Antibodies (60) and NVL Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat NVL NVL 289323  
NVL 4931 O15381
NVL 67459 Q9DBY8
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Top NVL Proteins at

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

NVL Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Nuclear VCP-Like (NVL) Interaction Partners

Human Nuclear VCP-Like (NVL) interaction partners

  1. knockdown of WDR74 leads to significant defects in the pre-rRNA cleavage within the internal transcribed spacer 1, occurring in an early stage of the processing pathway. When the dissociation of WDR74 from the MTR4-containing exonuclease complex was impaired upon expression of mutant NVL2, the same processing defect, with partial migration of WDR74 from the nucleolus towards the nucleoplasm, was observed.

  2. Results indicated that the NVL gene may contain overlapping common genetic risk factors for major depressive disorder and schizophrenia in the Han Chinese population

  3. results suggest that WDR74 is a novel regulatory protein of the MTR4-exsosome complex whose interaction is regulated by NVL2 and is involved in ribosome biogenesis

  4. suggest that NVL2 is involved in pre-rRNA processing by associating with the nuclear exosome complex and that MPP6 is required for maintaining the integrity of this rRNA processing complex

  5. these findings suggest that NVL2 is essential for telomerase biogenesis and provides an alternative approach for inhibiting telomerase activity in cancer.

  6. NVL2 might facilitate the dissociation and recycling of nucleolin, thereby promoting efficient ribosome biogenesis

  7. interaction of NVL2 with ribosomal protein L5 is ATP-dependent and likely contributes to the nucleolar translocation of NVL2

  8. Nuclear VCP/p97-like protein 2 might regulate the association/dissociation reaction of DOB1 with pre-ribosomal particles by acting as a molecular chaperone.

NVL Protein Profile

Protein Summary

This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin.

Gene names and symbols associated with Nuclear VCP-Like Proteins (NVL)

  • nuclear VCP-like (Nvl)
  • nuclear VCP-like L homeolog (nvl.L)
  • nuclear VCP-like (nvl)
  • nuclear VCP-like (NVL)
  • 1200009I24Rik protein
  • MGC52979 protein
  • MGC166259 protein
  • NVL protein
  • wu:fa20g10 protein
  • zgc:55732 protein

Protein level used designations for Nuclear VCP-Like Proteins (NVL)

nuclear valosin-containing protein-like , nuclear VCP-like , NVLp , nuclear VCP-like protein

289323 Rattus norvegicus
379269 Xenopus laevis
406805 Danio rerio
421326 Gallus gallus
457771 Pan troglodytes
480117 Canis lupus familiaris
532708 Bos taurus
100125138 Xenopus (Silurana) tropicalis
100440988 Pongo abelii
100476656 Ailuropoda melanoleuca
100547717 Meleagris gallopavo
100556567 Anolis carolinensis
100591361 Nomascus leucogenys
4931 Homo sapiens
67459 Mus musculus
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