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The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm.
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Data suggest that a pool of Nup88 on the nuclear side of the nuclear pore complex provides a novel, unexpected binding site for nuclear lamin A (show LMNA Antibodies).
Nup88 is up-regulated in response to hypertonic stress and acts to retain TonEBP (show NFAT5 Antibodies) in the nucleus, activating transcription of critical osmoprotective genes.
Nup88 regulates the activity of NF-kappaB (show NFKB1 Antibodies) at the level of nucleocytoplasmic transport.
Overexpression of the NUP88 is associated with cancer.
Nup88 may be related to the occurrence of endometrial cancers and premalignant lesions
These findings demonstrate that the NUP88-NUP98 (show NUP98 Antibodies)-RAE1 (show RAE1 Antibodies)-APC (show APC Antibodies)/CCDH1 axis contributes to aneuploidy
Nup62 and Nup88 protein levels were significantly decreased upon knockdown of O-GlcNAc transferase.
Serum Nup88 might be a candidate for a new biomarker implicated in the development and aggressiveness of colorectal cancer
Nup88 mRNA was overexpressed in colorectal cancers and the overexpression was associated with cancer development and aggressiveness.
association found between myometrial invasion and Nup88 expression in endometrial carcinoma
Gambogic acid exerts its anti-leukemia effects by regulating the expression and distribution of nucleoporin Nup88.
proper expression of Nup88 is critical for preventing aneuploidy formation and tumorigenesis.
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias.
, nucleoporin Nup88B
, nucleoporin Nup88A
, nucleoporin 88
, nuclear pore complex protein Nup88
, nuclear pore complex protein Nup88-like
, 88 kDa nucleoporin
, preimplantation protein 2
, 88 kDa nuclear pore complex protein
, nucleoporin Nup84
, nucleoporin Nup88
, nuclear pore complex protein 88