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Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. Additionally we are shipping Nucleoredoxin Proteins (11) and Nucleoredoxin Kits (9) and many more products for this protein.
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Mouse (Murine) Polyclonal NXN Primary Antibody for IHC (p), WB - ABIN656415
Jia, Cui, Meng, Xing, Shen, Wang, Liu, Wang, Lian, Zhang: Malignant transformation of human gastric epithelium cells via reactive oxygen species production and Wnt/β-catenin pathway activation following 40-week exposure to ochratoxin A. in Cancer letters 2016
identified nucleoredoxin as an interaction partner of Sec63; characterized this interaction; Sec63 is linked to the Wnt signaling pathways and this interaction may be the reason why mutations in SEC63 can lead to polycystic liver disease
Nucleoredoxin is a novel thioredoxin family member involved in cell growth and differentiation [review]
Nucleoredoxin regulates the Wnt/planar cell polarity pathway in Xenopus.
Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).
, nucleoredoxin 1