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The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Additionally we are shipping Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing Antibodies (93) and many more products for this protein.
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NAC1 forms a protein complex to function as a transcriptional regulator in cancer cells
a mutation in NACC1 causes microcephaly, profound developmental delays and/or intellectual disability, cataracts, severe epilepsy including infantile spasms, irritability, failure to thrive, and stereotypic hand movements
miR (show MLXIP Proteins)-339-5p inhibits migration and invasion in ovarian cancer by targeting NACC1 and BCL6 (show BCL6 Proteins). miR (show MLXIP Proteins)-339-5p may be a biomarker of metastasis in ovarian cancer; NACC1 had a predictive value for ovarian cancer progression
NAC1 has potential as a marker for distinguishing OED from CIS (show CISH Proteins)/OSCC
NACC1 can be modified by SUMO paralogues, and cooperates with promyelocytic leukemia protein (show PML Proteins).
strategy for the purification of tethered POZ domains that form forced heterodimers is described, and crystal structures of the heterodimeric POZ domains of Miz1 (show ZBTB17 Proteins)/BCL6 (show BCL6 Proteins) and of Miz1 (show ZBTB17 Proteins)/NAC1 are reported
NAC1 is essential and sufficient for activation of FOXQ1 (show FOXQ1 Proteins)
low expression of NAC1 predicts poor prognosis for patients with pancreatic ductal adenocarcinoma.
The identification of an NAC1 NLS (show ALDH1A2 Proteins) thus clarifies the mechanism through which NAC1 translocates to the nucleus to regulate the transcription of genes involved in oncogenicity and pluripotency.
Uterine sarcomas with NAC1 overexpression are clinically the most aggressive, chemoresistant, and radioresistant tumors.
a sub-network of four factors, Nac1, Oct4 (show POU5F1 Proteins), Tcf3 (show TCF7L1 Proteins), and Sox2 (show SOX2 Proteins), regulates mouse embryonic stem cell differentiation into the alternative mesendodermal and neuroectodermal fates.
The interaction of Nac1 with Miz1 (show PIAS2 Proteins) may thus be relevant to its mechanism of tumourigenesis in ovarian cancer.
NAC1 participates in the motility and differentiation of developing chondrocytes and cartilaginous tissues, and its expression is necessary to maintain normal axial patterning of murine skeleton.
The mouse Nac1 gene consist of six exons, with exon 2 containing an alternative splice donor, providing a molecular explanation of the splice variants observed in mouse and rat.
these data indicate involvement of NAC1 in the acute behavioral and neurochemical responses to psychomotor stimulants
Nanog (show NANOG Proteins) interacts with Nac1 through WNAAP to regulate the cell cycle of stem cells via the ERas/phosphatidylinositol 3-kinase/Akt (show AKT1 Proteins) pathway, but not pluripotency
This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9.
BEN domain containing 8
, BTB/POZ domain-containing protein 14B
, nucleus accumbens-associated protein 1
, transcriptional repressor NAC1
, nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
, BTB (POZ) domain containing 14B
, nucleus accumbens-1