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Negative regulator of sphingolipid synthesis.
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These associations with ORMDL3 are cell type specific, with the most significant 17q21 genotype effects on ORMDL3 expression and HSPA5 (show HSPA5 Proteins) induction evident in B cells. Together, these findings have implications for how the interaction of increased ORMDL3 and rhinovirus may predispose to asthma.
Chromosome 17q21 genes ORMDL3 and GSDMB (show GSDMB Proteins) are linked to asthma and other immune diseases. (Review)
The results confirmed that polymorphisms in NOD2 (Leu1007insC) and IRGM (show IRGM Proteins) genes are associated with increased risk of Crohn's disease; whereas the ORMDL3 variant is associated with susceptibility to ulcerative colitis in the Lithuanian early-onset inflammatory bowel disease population.
IRF-3 (show IRF3 Proteins) is an important regulator of ORMDL3 induction following RSV infection by binding directly to the promoter of ORMDL3
MiR (show MLXIP Proteins)-665 induced apoptosis by inhibiting XBP1 (show XBP1 Proteins) and ORMDL3.
These studies suggest that increased levels of ORMDL3 contribute to antiviral defense to rhinovirus infection in mice (hORMDL3(zp3 (show ZP3 Proteins)-Cre) mice which have universal increased expression of human ORMDL3) through pathways that may include IFNs (IFN-alpha (show IFNA Proteins), IFN-beta (show IFNB1 Proteins), IFN-lambda), OAS (show SMOC1 Proteins), and RNAse L (show RNASEL Proteins).
this study demonstrated the upregulation of (show ATF6 Proteins) ORMDL3 (show BECN1 Proteins)in patients with systemic lupus erythematosus
ORMDL3 might influence de novo sphingolipid metabolism downstream of serine palmitoyltransferase
modest changes (8-13%) in promoter methylation levels of ZPBP2 (show ZPBP2 Proteins) and GSDMA (show GSDMA Proteins) may cause substantial changes in RNA levels and allelic expression of ZPBP2 (show ZPBP2 Proteins) and ORMDL3 is mediated by DNA methylation (show HELLS Proteins)
Decreased ORMDL3 expression increased levels of free sphingoid bases and sphingoid base phosphates, and also caused increases in cellular levels of ceramides.
Expression levels of ORMDL3, phosphorylated (p)ERK (show EPHB2 Proteins) and MMP9 (show MMP9 Proteins) were significantly greater in the asthmamodel group; however, in the group pretreated with budesonide their expression was reduced.
ORMDL3 mediates the autophagy via the ATF 6 (show ATF6 Proteins)-Beclin1 (show BECN1 Proteins) autophagy pathway, and it facilitates the survival of splenic B cells via promoting autophagy and suppressing apoptosis
inhibiting ORMDL3 in airway epithelial cells plays a significant role in induction of allergen-induced increases in airway hyperresponsiveness
ORMDL3, an asthma susceptibility gene identified by genome-wide association studies, contributes to key pathways that promote changes in airway physiology during allergic immune responses.
Mediated by GATA3 (show GATA3 Proteins) through targeting promoter region of ORMDL3.
Downregulation of ORMDL3 expression in mast cells enhances AKT (show AKT1 Proteins) and NF-kappaB (show NFKB1 Proteins)-directed signaling pathways and chemotaxis and contributes to the development of mast cell-mediated local inflammation in vivo.
overexpression of ORMDL3 regulates ceramide homeostasis in cells in a complex manner and suggest that local FTY720 administration might be a useful therapeutic intervention for the control of allergic asthma.
the contribution of ORMDL3 to asthma risk may involve changes in sphingolipid metabolism
These studies provide evidence that ORMDL3 plays an important role in vivo in airway remodeling potentially through ATF6 (show ATF6 Proteins) target genes.
Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity).
ORM1-like protein 3
, liver regeneration-related protein LRRGT00183