ORM1-Like 3 (S. Cerevisiae) Proteins (ORMDL3)

Negative regulator of sphingolipid synthesis. Additionally we are shipping ORMDL3 Antibodies (31) and ORMDL3 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ORMDL3 94103 Q8N138
ORMDL3 66612 Q9CPZ6
Rat ORMDL3 ORMDL3 360618 Q6QI25
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Top ORMDL3 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days

ORMDL3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for ORM1-Like 3 (S. Cerevisiae) (ORMDL3) Interaction Partners

Human ORM1-Like 3 (S. Cerevisiae) (ORMDL3) interaction partners

  1. These results showed that the PBC susceptibility allele of rs12946510 disrupted the enhancer region for ORMDL3 and GSDMB gene expression (Fig. 6). Chromatin interaction between the sequence that contains rs12946510 and the upstream sequence of ORMDL3 and GSDMB also supported this enhancer model

  2. ORMDL3 inhibits the generation of sphingolipids including ceramide and S1P

  3. These associations with ORMDL3 are cell type specific, with the most significant 17q21 genotype effects on ORMDL3 expression and HSPA5 induction evident in B cells. Together, these findings have implications for how the interaction of increased ORMDL3 and rhinovirus may predispose to asthma.

  4. Chromosome 17q21 genes ORMDL3 and GSDMB are linked to asthma and other immune diseases. (Review)

  5. The results confirmed that polymorphisms in NOD2 (Leu1007insC) and IRGM genes are associated with increased risk of Crohn's disease; whereas the ORMDL3 variant is associated with susceptibility to ulcerative colitis in the Lithuanian early-onset inflammatory bowel disease population.

  6. IRF-3 is an important regulator of ORMDL3 induction following RSV infection by binding directly to the promoter of ORMDL3

  7. MiR-665 induced apoptosis by inhibiting XBP1 and ORMDL3.

  8. These studies suggest that increased levels of ORMDL3 contribute to antiviral defense to rhinovirus infection in mice (hORMDL3(zp3-Cre) mice which have universal increased expression of human ORMDL3) through pathways that may include IFNs (IFN-alpha, IFN-beta, IFN-lambda), OAS, and RNAse L.

  9. this study demonstrated the upregulation of ORMDL3 in patients with systemic lupus erythematosus

  10. ORMDL3 might influence de novo sphingolipid metabolism downstream of serine palmitoyltransferase

  11. modest changes (8-13%) in promoter methylation levels of ZPBP2 and GSDMA may cause substantial changes in RNA levels and allelic expression of ZPBP2 and ORMDL3 is mediated by DNA methylation

  12. Decreased ORMDL3 expression increased levels of free sphingoid bases and sphingoid base phosphates, and also caused increases in cellular levels of ceramides.

  13. ORMDL3 overexpression is associated with asthma.

  14. The TT homozygote and the T allele of rs7216389 in ORMDL3 increased bronchiolitis risk. The rs7216389 polymorphism may be a predictor for identifying infants with predisposition to virus-induced wheezing to persistent asthma.

  15. Two single nucleotide polymorphisms regulating ORMDL3 expression (rs7216389 and rs9303277) significantly associated with atherosclerosis risk and the evidence of increased ORMDL3 expression in AS cases compared to controls.

  16. The SNP (rs7216389) of ORMDL3 does not influence the expression of OPN and TGF-beta1, suggesting that it may not be associated with airway remodeling.

  17. ORMDL3 variants have been shown to be associated with Asthma in children with Rhinovirus infections -induced wheezing illnesses.

  18. The meta-analysis indicates that ORMDL3 rs7216389 may contribute to increasing susceptibility to asthma. (Meta-analysis)

  19. genetic polymorphisms are associated with childhood asthma, and with changes in TH2 cytokines levels

  20. the contribution of ORMDL3 to asthma risk may involve changes in sphingolipid metabolism

Mouse (Murine) ORM1-Like 3 (S. Cerevisiae) (ORMDL3) interaction partners

  1. Expression levels of ORMDL3, phosphorylated (p)ERK and MMP9 were significantly greater in the asthmamodel group; however, in the group pretreated with budesonide their expression was reduced.

  2. ORMDL3 mediates the autophagy via the ATF 6-Beclin1 autophagy pathway, and it facilitates the survival of splenic B cells via promoting autophagy and suppressing apoptosis

  3. ORMDL3 might influence de novo sphingolipid metabolism downstream of serine palmitoyltransferase

  4. inhibiting ORMDL3 in airway epithelial cells plays a significant role in induction of allergen-induced increases in airway hyperresponsiveness

  5. ORMDL3, an asthma susceptibility gene identified by genome-wide association studies, contributes to key pathways that promote changes in airway physiology during allergic immune responses.

  6. Mediated by GATA3 through targeting promoter region of ORMDL3.

  7. Downregulation of ORMDL3 expression in mast cells enhances AKT and NF-kappaB-directed signaling pathways and chemotaxis and contributes to the development of mast cell-mediated local inflammation in vivo.

  8. overexpression of ORMDL3 regulates ceramide homeostasis in cells in a complex manner and suggest that local FTY720 administration might be a useful therapeutic intervention for the control of allergic asthma.

  9. the contribution of ORMDL3 to asthma risk may involve changes in sphingolipid metabolism

  10. These studies provide evidence that ORMDL3 plays an important role in vivo in airway remodeling potentially through ATF6 target genes.

  11. ORMDL3 promotes eosinophil trafficking and activation via regulation of CD18, CD49d, and CD48.

  12. signaling pathway cAMP/PKA/CREB plays an important role in regulating ORMDL3 expression

ORMDL3 Protein Profile

Protein Summary

Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity).

Gene names and symbols associated with ORMDL3

  • ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3)
  • ORM1-like 3 (S. cerevisiae) (Ormdl3)
  • ORMDL sphingolipid biosynthesis regulator 3 (Ormdl3)
  • 2810011N17Rik protein
  • AI315223 protein
  • LRRGT00183 protein

Protein level used designations for ORMDL3

ORM1-like protein 3 , liver regeneration-related protein LRRGT00183

94103 Homo sapiens
66612 Mus musculus
360618 Rattus norvegicus
615368 Bos taurus
100479284 Ailuropoda melanoleuca
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