anti-One Cut Homeobox 2 (ONECUT2) Antibodies

Mouse (Murine) One Cut Homeobox 2 (ONECUT2) interaction partners

1. Onecut1 (show ONECUT1 Antibodies) and Onecut2 have roles in operating downstream of Pax6 (show PAX6 Antibodies) to regulate horizontal cell development

2. similar to Onecut1 (show ONECUT1 Antibodies), Onecut2 is also necessary for the formation of normal numbers of horizontal cells in the developing retina.

3. identified downstream genes of Oc1 and Oc2 that shows that the onecut factors suppress the production of the late cell type, rods, indicating that the two factors contribute to the competence of retinal progenitor cells for early retinal cell fates

4. OC-2 is required for development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus.

5. Onecut2 and Onecut1 (show ONECUT1 Antibodies) have similar expression patterns throughout retinal development and may also function in the genesis and maintenance of retinal horizontal cells.

6. Data show that Onecut-2/Onecut-3 (show ONECUT3 Antibodies) double knockout is a perinatal lethal.

7. These results indicate that the expression of HNF-6 (show ONECUT1 Antibodies) and OC-2 regulators of liver and pancreas development is modulated by miR (show MLXIP Antibodies)-495 and miR (show MLXIP Antibodies)-218.

8. We describe here the cloning of mouse (m) OC-2 and its expression pattern in the mouse embryo.

9. although hepatocyte nuclear factor (HNF)6/onecut(OC)-2 and perhaps HNF1 activate the P2 promoter in the embryo, increasing HNF4alpha1 expression throughout development causes a switch to essentially exclusive P1 promoter activity in the adult liver

10. Onecut transcription factor Onecut2 inhibits activin (show Actbeta Antibodies)/TGF beta (show TGFB1 Antibodies) signaling in the parenchyma, and this allows normal hepatocyte differentiation.

Human One Cut Homeobox 2 (ONECUT2) interaction partners

1. These data indicated that OC-2 (show CTSK Antibodies) was an upstream regulator of VEGFA (show VEGFA Antibodies) and silencing OC-2 (show CTSK Antibodies) could inhibit ovarian cancer angiogenesis and tumor growth.

2. Bioinformatics-based prediction, combined with qRT-PCR analysis and Western blotting, identified Onecut2 and SIRT1 (show SIRT1 Antibodies) as the 2 prominent miR (show MLXIP Antibodies)-9 target genes under the conditions tested. In this study, Onecut2 and SIRT1 (show SIRT1 Antibodies) were confirmed as miR (show MLXIP Antibodies)-9 target genes, which will help future investigations to probe in greater detail the role of miR (show MLXIP Antibodies)-9 in Nonalcoholic Fatty Liver Disease.

3. Data show that ONECUT2, IGF2BP1 (show IGF2BP1 Antibodies), and ANXA2 (show ANXA2 Antibodies) proteins were confirmed to be microRNA-9 (miR (show MLXIP Antibodies)-9) targets and aberrantly upregulated in hepatocellular carcinoma (HCC (show FAM126A Antibodies)).

4. our data showed that transcript factor Onecut2 is involved in the EMT (show ITK Antibodies), migration and invasion of CRC (show CALR Antibodies) cells; miR (show MLXIP Antibodies)-429 inhibits the initiation of EMT (show ITK Antibodies) and regulated expression of EMT (show ITK Antibodies)-related markers

5. Mutations at the -5/-6 site of the F9 promotor account for the majority of hemophilia B Leyden cases and disrupt the binding of ONECUT1 (show ONECUT1 Antibodies) and ONECUT2.

6. OC2 transcription factor is a direct target of T-bet in type-1 T-helper cells.

7. A CpG island proximal to ONECUT2 is frequently methylated in diffuse large B-cell lymphoma (DLBCL).